The invention discloses a virtual serial port screen simulation system and a simulation method thereof. The virtual serial port screen simulation system comprises a resource reading module, a display driving module, a touch screen driver, a serial port communication module, a command processing module, a storage module and a main program module, wherein the resource reading module provides an interface for reading an image resource, a font library resource and a system configuration resource, the display driving module provides a display-related interface, and the touch screen driver realizes touch compression action detection and reads touch coordinate parameters; the serial port communication module provides an interface for receiving and transmitting data by virtue of a serial port and records communication historical data; the storage module is used for storing system parameters and a control state of a serial port screen; and the main program module builds the modules into a complete and executable program. The virtual serial port screen simulation system has the advantages that a developer can directly complete development and debugging of the serial port screen on a PC, the resource is avoided from being repeatedly downloaded to the serial port screen for many times, and time of the developer is saved.