The invention relates to a high-altitude 
environmental simulation cabin, and optimally selects a highland airline civil aircraft 
simulation cabin and a construction method thereof. A vacuum 
system anda special temperature 
system are added on the basis of a 
hyperbaric oxygen chamber, and the improved parts mainly include the functions of an air supplying and discharging 
system, a 
humidity adjusting system and an 
oxygen supplying and discharging system; after transformation, a high-low pressure 
oxygen cabin with a pressure increasing function and a pressure decreasing function can be obtained,and besides the functions of a conventional 
hyperbaric oxygen therapy, the function of simulating a high-altitude environment is further achieved, so that the cabin can serve as the highland airline 
simulation cabin. The highland airline 
simulation cabin can be used for selection of pilots and astronauts, high-altitude physical and psychological training, medical identification, low-pressure 
oxygen deficit simulation experience, highland adaptability experience, 
aerospace medical experience, physical training, basic medical researches and other work.