The invention discloses a pesticide spraying device. The pesticide spraying device comprises a base, a tray, a pesticide liquid box, a liquid delivering pipe and a spray head. During work, a lifting unit is arranged between the base and the tray and can drive the tray to move in the vertical direction, the height of the pesticide liquid box is adjusted, and then a purpose of adjusting the height of the spray head is achieved; meanwhile, the pesticide liquid box can rotate relative to the tray, then the liquid delivering pipe is driven to rotate, the liquid delivering pipe rotates to change theorientation of the spray head, or rotation is kept to make the spray head spray in a circumferential manner, and the pesticide spraying efficiency is improved; in addition, the liquid delivering pipecomprises a rotating section, the rotating section is connected with a supporting rod, the supporting rod is hinged to the rotating section, the length of the supporting rod can be adjusted, and a purpose of adjusting the pitching angle of the spray head can be achieved by adjusting the length of the supporting rod. According to the pesticide spraying device, the height and angle of the spray head can be adjusted, meanwhile, the spray head can be driven to rotate for work, the workload of operators is greatly reduced, and the pesticide spraying efficiency is improved.