The invention discloses a mask plate, a manufacturing method thereof, a display panel and a display device. According to the mask plate, the manufacturing method thereof, the display panel and the display device, a traditional mask plate is improved, particularly, a notch is formed at the positions where at least part of the side cut surface of each opening of the mask plate intersects with the surface of one side close to a substrate during evaporation, the notches are formed through the chemical etching method or the laser cutting method, the area of the side, close to the substrate, of an opening is made to be larger than the area of the side, away from the substrate, of the opening during evaporation, in this way, the area of the marginal area of an evaporated film on the substrate is increased, the flatness of the marginal area is improved, the possibility that the metal film formed in the later stage breaks due to the fact that a step is too high is avoided, and the yield of products is increased.