The invention provides a self-powered wireless vertical mouse. The self-powered wireless vertical mouse comprises a housing, a left key, a right key, a roller middle key, an electromagnetic power supply module, a frictional power supply module, a fixed plate, a rectifier circuit board, a rechargeable battery and a bilateral switch; the housing is designed to be vertical and comprises a left-side housing, a right-side housing, a front-side housing and a base; the frictional power supply module is arranged in the left-side housing, and the left key, the right key and the roller middle key are arranged in the right-side housing; or the frictional power supply module is arranged in the right-side housing, and the left key, the right key and the roller middle key are arranged in the left-side housing; the electromagnetic power supply module comprises a winding coil, a gear bank and a rocking handle; the rocking handle is arranged on the front-side housing; the frictional power supply module is composed of a first friction interface and a second friction interface, wherein the first frictional interface is attached to the housing, while the second friction interface is arched and fixed with the edge of the first friction interface.