The invention provides an active contour model image segmentation method based on local Gaussian distribution fitting and local signature energy driving, and belongs to the technical field of image processing. The active contour model image segmentation method based on local Gaussian distribution fitting and local signature energy driving includes the following steps: S1, inputting an original image I(x); S2, calculating the local entropy of the image so as to obtain a local signature energy item of the image; S3, initialization level function Phi=Phi0(x); S4, initialization coefficients: alpha, beta, lambda1, lambda2, Mu, Nu, epsilon, sigma and deltat; S5, calculating local fitting energy items e1 and e2; S6, update level set function Phi; and S7, determining whether the level set evolution curve can satisfy the convergence criterion, and if not, turning to the step S5 to continue calculation until the termination condition is satisfied. The active contour model image segmentation method based on local Gaussian distribution fitting and local signature energy driving can realize segmentation of the target having nonuniform gray scale, is not sensitive to the shape, the size and the position of the initial contour curve, and has certain noise immunity.