The invention discloses a wire cutting device with a clamping mechanism. The wire cutting device comprises a platform, supporting rods are fixedly connected to the top of the platform, the tops of thesupporting rods are fixedly connected with a top plate, a movable handle is arranged on the top of the top plate, and the bottom of the movable handle is fixedly connected with a cutter holder. The bottom of the top plate is fixedly connected with fixing rods, the bottoms of the fixing rods are fixedly connected with baffles, the bottom of the cutter holder is provided with springs, the outer surfaces of the fixing rods are sleeved with the springs, a cutter is welded to the bottom of the cutter holder, and the top of the platform is fixedly connected with a clamping base. By arranging the clamping base, a strip-like opening, a rubber plate, a bolt, a fixed plate, a winding roller, an insertion rod, a fixing frame, a movable plate, a motor, a screw, clamping rods and threaded pins, the problems are solved that an existing wire cutting device is not provided with the clamping mechanism, during cutting, a nylon product is easy to loosen, when the nylon product is cut, the cutting platform can shake, and the stability is poor.