The invention belongs to the technical field of enzyme production, and particularly relates to a cranberry probiotic enzyme and a preparation method thereof. The cranberry probiotic enzyme is preparedfrom the main raw materials of cranberries, tangerines and lemons, nutrient components of the raw materials are richer on the basis of scientific reasonable collocation, under the fermentation actionof probiotics, the kinds, the amounts and fermentation duration of the probiotics are strictly controlled at the same time, fuller fermentation of the raw materials is guaranteed, finally, nutrient substances, active substances and antioxidant substances in the raw materials can be released completely, and finally, the cranberry probiotic enzyme which has the efficacy of maintaining beauty, nourishing skin and reducing blood pressure is obtained.