The invention relates to a manufacturing process for centrifugal casting of multi-element eutectic high-alloy rolls, and belongs to the technical field of metallurgical rolls. The technical scheme includes that eutectic compositions are selected as materials of a roll working layer, and besides five elements of C, Mn, Si, P and S commonly existing in steel, not less then five alloying elements of Cr, W, Mo, V, Nb, Ti, Al, Cu, B and Mg need to be added into the roll materials to form a multi-element alloying state; carbon content of the roll materials is controlled to be 1.3%-2.8% in mass percent. The manufacturing process is small in solidification temperature range of the eutectic compositions, and particularly suitable for obtaining high-quality castings under the circumstance that feeding conditions are insufficient; the castings are crystallized simultaneously, and optimal in composition uniformity, concentrated cavity shrinkage is formed, metallic yield by casting moulding is high; the metal is solidified at the same time, and casting stress in the process of solidification is minimum; the eutectic compositions in alloy are lowest in melting point, and smelting cost is also low; liquid of the eutectic compositions is best in fluidity; castability is improved, and abrasion resistance and heat resistance are taken into consideration.