The invention discloses a method for synthesizing
econazole nitrate by using a one-pot method, and belongs to the technical field of
synthesis methods of
econazole nitrate. The method comprises: carrying out an N-
alkylation reaction under the actions of K2CO3 / KOH / Al2O3 and PEG-200 by using 1-(2,4-dichlorophenyl)-2-chloro-
ethanol and
imidazole as raw materials to obtain
toluene-containing imidazoleethanol; and carrying out an O-
alkylation reaction on the
toluene-containing
imidazole ethanol and p-chlorobenzyl
chloride under the actions of K2CO3 / KOH / Al2O3 and PEG-200 to obtain
econazole nitrate. According to the method of the invention, the intermediate
imidazole ethanol is directly subjected to the O-
alkylation reaction without
water washing to achieve nearly
neutral state, re-
crystallization and
drying, so that the environmental
pollution caused by
drying is reduced, the imidazole ethanol dissolving process is shortened, the reaction efficiency is improved, and the
solvent recovery frequency is reduced; and after the O-alkylation reaction is finished, the
impurity removal is performed before the acidification, so that the high product
viscosity caused by many impurities is greatlyreduced, the
solid-liquid separation is easy to realize, the one-pot production is realized, the cost is low, the operation is simple and convenient, and the method is suitable for industrial popularization.