The invention discloses a method for synthesizing econazole nitrate by a one-pot method, which belongs to the technical field of econazole nitrate synthesis method and comprises the following steps: using 1-(2,4-dichlorophenyl)-2-chloro-ethanol and imidazole as raw material, in K 2 CO 3 / KOH / A1 2 o 3 And under the effect of PEG-200, through N-alkylation reaction, obtain the imidazole ethanol containing toluene; The imidazole ethanol containing toluene and p-chlorobenzyl 2 CO 3 / KOH / A1 2 o 3 Under the action of PEG-200, O-alkylation reaction occurs to obtain econazole nitrate; the intermediate imidazole ethanol of the present invention does not need to be washed to near neutrality, recrystallization and drying, and directly carries out O-alkylation reaction, reducing the Due to the environmental pollution caused by drying, the process of dissolving imidazole in ethanol is shortened, the reaction efficiency is improved, and the number of solvent recovery is reduced. High viscosity, easy to realize solid-liquid separation, realize one-pot production, low cost, easy to operate, suitable for industrialization promotion.