The invention relates to an ultrasound, laser and machine combined machining method, an ultrasonic vibration clamp, a machine tool and a laser device. Under the condition that a to-be-machined workpiece generates ultrasonic vibration, laser generated by the laser device roughly machines the to-be-machined workpiece, and a damage layer with cracks is generated on the to-be-machined workpiece through laser machining; ultrasonic vibration is used for increasing expansion of the damage layer, and then finish machining is conducted on the to-be-machined workpiece through a cutter. The ultrasonic vibration is beneficial to disengagement of molten drops generated after the laser ablates the to-be-machined workpiece, so that the contact between the to-be-machined workpiece and the laser is increased. The laser ablation effect can cause the surface of the to-be-machined workpiece to generate the damage layer with microcracks, under the action of ultrasonic vibration, after the microcracks are formed, due to the existence of high-frequency vibration, stress in the material is released more completely, the expansion of the microcracks is stably enlarged, and then the expansion of the damage layer is stably expanded; and in this way, removal of the material can be facilitated when the cutter conducts finish machining on the machined workpiece, the cutting force and cutter abrasion are reduced, and the machining efficiency is improved.