The invention discloses an oscillation microbubble
chip, a
separation system and an acoustic manipulation method, the device utilizes the acoustic
eddy current effect induced by oscillation
microbubbles to realize micro-nano particle acoustic manipulation, the
chip structure and operation are simple, the
biocompatibility is high, and by designing the
chip structure, due to the breathable and water-repellent characteristics of PDMS and the
surface tension of fluid, the micro-nano particle acoustic manipulation can be realized. Alternatively arranged equilateral triangle column cavities with different sizes are formed on the side wall of the PDMS
microfluidic channel to anchor bubbles. Bubble oscillation is driven by bulk acoustic
waves generated by exciting a piezoelectric
transducer through a
signal generator, symmetrical vortexes are formed on the surfaces of the bubbles through secondary
acoustic radiation force generated by bubble oscillation, then large-size particles are captured, and small-size particles flow to an outlet along with flowing under the action of drag force. Gradient separation is adopted to separate
small particles from a
mixed solution and enrich large particles, enrichment, separation and other control of microparticles are achieved through the acoustic vortex
field effect of a specific structure, great potential is achieved in biological research, the structure is simple, the equipment cost is low, and integration is easy.