The invention belongs to the technical field of environmental monitoring, and discloses a comprehensive environmental quality mobile monitoring system, which comprises a mobile monitoring vehicle andan industrial personal computer integrated in a vehicle body of the mobile monitoring vehicle; and a particulate laser radar and an atmospheric ozone laser radar are also arranged in the mobile monitoring vehicle. According to the technical scheme of the invention, the mobile monitoring system is used for carrying out monitoring while moving through the mobile monitoring vehicle, online data is monitored and analyzed in real time, and geographic position-species-concentration relevance and other means are established, a regional atmospheric environment pollution dynamic direct reading mode iscreated, and important contributions are provided for realizing fine management of atmospheric environment pollution; an ambient air pollution pre-tracing system is combined, early warning and sourcetracing of atmospheric environmental pollution can be achieved, government' control of VOCs enterprise emission' becomes possible, and compared with fixed point monitoring, the mobile monitoring system is more comprehensive in monitoring effect, accurate investigation, accurate strike and accurate treatment of regional environmental pollution can be achieved, the environmental treatment efficiencyis greatly improved, and the social cost is saved.