The invention discloses a nasal catheter fixation device for use with a neonatal CPAP breathing machine. The device includes a square rod support base, a nasal intubation plate, an air duct pipe, a connecting bar rack, a human-computer interface table, a stand column plate and a liquid oxygen mixing valve seat. Through combination of the nasal intubation plate and the liquid oxygen mixing valve seat, and through treatment with a humidification water tank liquid passage and a pure oxygen storage box air passage utilizing a bent backwashing pipe connector cap of the liquid oxygen mixing valve seat, the retention amount of water vapor in the nasal intubation plate and the air duct pipe is ensured to be lowest, and recoil force allows a rotary sieve to filter condensate of the tidal volume, thus ensuring that water vapor and oxygen are mixed to achieve an oxygen supplementing wetting effect, relieving alveolar intumescence by vapor attachment, adjusting a durable dried situation of the lung passage, making respiratory muscle loose, wet and elastic, promoting increase of the functional residual volume, improving lung compliance, improving respiratory regularity of newborns, and allowingthe device to automatically match with needs of a child's body to achieve micro-adjustment and high oxygen mixing adaptability.