The invention discloses an air-ground combined agricultural spraying device and application of the air-ground combined agricultural spraying device. The air-ground combined agricultural spraying device comprises an aircraft, connecting pipelines, a winch mechanism, a winch mechanism supporting rod, a power system, a liquid pesticide storage tank, a transport vehicle, a pressure pump, an inner passage, a propeller, a propeller beam, a propeller drive motor, an aircraft bracket and spray heads. According to the air-ground combined agricultural spraying device, the large-size heavy liquid pesticide tank, the pressure pump and the power system are installed on the transport vehicle, a spraying mechanism is installed on the small unmanned rotorcraft, and an air device and a ground device are connected through hoses and wires. In this way, aerial spraying in a limited area within ultra-long auto-hover time is achieved, and meanwhile long-distance ground transportation of an aircraft is achieved.