Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

33results about How to "Fast quenching" patented technology

Refrigerated chest for rapidly quenching beverages and visually identifying when such beverages reach target temperature

The cooling chest for rapidly quenching beverages includes a quench tray for holding containers of beverage. The quench tray is lowered into salt-water or other cooling liquid which is cooled by a refrigeration unit. A processing device determines the temperature of the beverages within the containers within the quench tray and further activates a mechanism for removing the quench tray from the water or cooling liquid when the desired temperature is reached. The processing device can also activate the mechanism for removing the quench tray from the water or cooling liquid when the upper lid or access doors are opened.
Owner:LAUCHNOR JOHN C

Absorption and quench method for biomass pyrolysis product

A biomass pyrolysis product is quenched by direct cooling with a cold quench fluid and initial product separation is performed based on boiling point and solubility in the quench fluid. A properly chosen quench fluid may act as a selective solvent, thus providing dilution of unstable precursors of pyrolytic lignin or other heavy by-products, and / or separation of certain undesirable pyrolysis oil components such as water and light acids.
Owner:PHILLIPS 66 CO

High-speed-quenching and high-speed-recovery free-operation single-photon detection system

The invention discloses a high-speed-quenching and high-speed-recovery free-operation single-photon detection system. The system is characterized in that the system includes an SPAD (single-photon avalanche diode), a peripheral circuit module 1 thereof, an identification and shaping module 2, a time delay and amplification module 3 and an active quenching and recovery module 4; the SPAD and the peripheral circuit module 1 thereof extract avalanche signals and input the avalanche signals to the identification and shaping module 2; the identification and shaping module 2 identifies and shapes the avalanche signals so as to obtain counting signals; the counting signals are inputted to the time delay and amplification module 3 and then are divided into two paths, wherein one path passes through an operational amplifier, so that active quenching signals can be obtained, and the other path is subjected to dead time setting delay and shaping, so that active recovery signals are obtained; the active quenching signals and the active recovery signals are inputted to the active quenching and recovery module 4; and the electric level signals of the active quenching and recovery module 4 are connected into the anode of the SPAD, so that the high-speed quenching and high-speed recovery of the SPAD are realized. With the system adopted, the detection efficiency and counting rate of a single-photon detector can be improved.
Owner:UNIV OF SCI & TECH OF CHINA

Dual-beam super-resolution optical storage material read-write device and read-write method

ActiveCN108899053AResolve recordsSolve the problem of readingRecord information storageOptical beam guiding meansFluorescenceDual beam
A dual-beam super-resolution optical storage material read-write device comprises an optical path and a computer; the optical path consists of a recording optical path, a reading-out optical path anda fluorescence collecting optical path. A read-write method is provided. The invention adopts pulsed light induction-continuous photoinhibition quenching recording mode, can quickly read information,solves the problem of recording and reading of materials simultaneously for the first time in the field of super-resolution optical storage, overcomes the erasing effect of photochromic materials in super-resolution recording, and obtains smaller recording spots and improve the storage density of optical discs.
Owner:SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI

Self-adaptive adjustment circuit for gain of array single-photon avalanche photodiode

ActiveCN108681362AImplement Gain Consistency DetectionAvoid direct regulationElectric variable regulationPhoton detectionHemt circuits
The invention discloses a self-adaptive adjustment circuit for the gain of an array single-photon avalanche photodiode. The self-adaptive adjustment circuit comprises a current biasing circuit, current monitoring circuits and active quenching circuits; the current biasing circuit is used for providing equal current for each SPAD pixel unit; the current monitoring circuits are composed of current mirror circuits and used for judging the working states of the SPAD pixel units according to the current of the monitored SPAD pixel units and outputting different voltage signals for gain control overthe SPAD pixel units to serve as input signals of the active quenching circuits; the active quenching circuits are used for generating and outputting pulse signals according to the voltage signals output by the current monitoring circuits to control quenching tubes to be switched on so that quenching of avalanche signals is achieved to be ready for arrival of next photon detection. According to the self-adaptive adjustment circuit, by adopting a control method of a current mode, the reverse bias voltage of the SPAD is self-adaptively adjusted, the defect that a traditional voltage mode is complicated to control is overcome, and the self-adaptive adjustment circuit is suitable for array application, easy to expand and capable of achieving consistency detection of the gain of the array single-photon avalanche photodiode.
Owner:SOUTHEAST UNIV

Automotive light gear and manufacturing process thereof

The invention discloses a manufacturing process of an automotive light gear. The manufacturing process of the automotive light gear comprises the following steps of first, carrying out rough machiningon a gear raw material to obtain a gear blank with a central large hole; second, carrying out heat treatment on the gear blank; third, carrying out semifinishing on the gear blank to obtain a semi-finished product of gear with teeth; fourth, carrying out plasma surface hardening carbonitriding treatment and sulfurizing treatment on the semi-finished product of gear; and fifth, carrying out secondary finish machining on the semi-finished product of gear to obtain a finished product of gear. According to the manufacturing process of the automotive light gear, because of the tooth surface hardening carbonitriding treatment and sulfurizing treatment, the hardening time is shortened, energy consumption is reduced, the surface friction coefficient is decreased, and the surface abrasive resistance is improved.
Owner:NANJING INST OF TECH

Mild gas turbine combustion chamber

The invention provides a mild gas turbine combustion chamber, and relates to the technical field of gas turbines. Based on the defects that a traditional gas turbine combustion chamber is severe in working environment, large in heat load, high in temperature and speed, complex in flow field and the like, a fuel oil single-point injection combustor is changed into multi-point injection of the wallsurface of a flame tube, multi-point mixing of fuel oil and air can be achieved, a mild combustion area is established, and stable and efficient combustion is achieved; the wall surface of the flame tube is designed to be of a double-layer wall structure, the middle of the flame tube is designed to be of a honeycomb sandwich structure, high-temperature airflow inside the flame tube can be reasonably cooled, it is guaranteed that the fuel oil in a fuel oil branch pipe is sufficiently preheated, and meanwhile, the effect of reducing noise generated in the working process of the combustion chamber can be achieved; and a boss structure is designed in the flame tube, the flame tube can be partitioned, flames can be quenched to the mild combustion area from an fuel-rich combustion area rapidly,emission of nitric oxide is reduced, and the stable combustion of the fuel in the flame tube is achieved.
Owner:NORTHWESTERN POLYTECHNICAL UNIV

Automatic quenching device for gear machining

The invention discloses an automatic quenching device for gear machining, and relates to the technical field of gear machining. The problems that in the existing high-frequency quenching process, theoperation speed is low, production efficiency is low, workloads on workers are high and the hands of the workers are easily scalded by a quenching device at a high working temperature are solved. Theautomatic quenching device comprises a machine body. A group of motors are fixedly connected with the upper end face of the machine body. A group of rotating middle shafts are axially connected with the center of the machine body. Three groups of part carriers are arrayed on and axially connected with the outside circumference of a carrying plate. A group of lifting blocks are fixedly connected with a piston rod of a cylinder. The carrying plate is axially connected with the lifting blocks. A group of middle belt wheels are axially connected with the upper portion of the right side of the machine body. The automatic quenching device is simple in structure, low in manufacturing cost, convenient to control, easy to operate, high in quenching speed and high in production efficiency and meanwhile prevents workers from touching heated gears to get scalded.
Owner:泰州市新亚传动设备有限公司

Atmosphere controlled quenching device for magnetically buffering fall of furnace body

The invention discloses an atmosphere controlled quenching device for magnetically buffering fall of a furnace body, and belongs to the technical field of metallurgical equipment. A vertical guide rail is arranged in a case, a guide shoe 11 capable of sliding on the vertical guide rail is arranged on three groups of fixed supporting plates on the vertical guide rail, and a cooling chamber and thefurnace body connected with the cooling chamber are fixed in two cavities formed among the three groups of fixed supporting plates from top to bottom respectively; fixed brackets are arranged at the upper end and the lower end of the cooling chamber; the furnace body and the water-cooled cooling chamber connected together are connected with a traction steel wire of a tractor used for guiding the device to move upwards and arranged at the top of equipment; and a magnet A is arranged at the bottom of the furnace body. A magnet B for generating a repulsive force for retarding free fall of the furnace body and the cooling chamber together with the magnet A is arranged relatively on the same pole as the magnet A at the bottom of the case. By adopting natural fall of the furnace body and the water-cooled cooling chamber and shock absorption stop of the permanent magnets, the atmosphere controlled quenching device has low investment, is easily implemented, and has high quenching speed.
Owner:BEIJING UNIV OF TECH

High-frequency quenching and automatic cooling integrated machine

The invention discloses a high-frequency quenching and automatic cooling integrated machine. The high-frequency quenching and automatic cooling integrated machine comprises a high-frequency quenchingmachine; a sensor of the high-frequency quenching machine is in a U shape and horizontally arranged, a base is arranged on one side of the sensor of the high-frequency quenching machine, and an L-shaped mounting plate is arranged on the base; two guiding columns are parallelly mounted between a horizontal plate surface of the L-shaped mounting plate and the base in the vertical direction, and a sliding seat is mounted on the two guiding columns in a sleeving mode; a lead screw transmission mechanism is mounted on the L-shaped mounting plate in the vertical direction, and a nut of the lead screw transmission mechanism is fixed in the sliding seat; a workpiece clamp is arranged on the position, corresponding to the lower portion of the sensor, of the sliding seat and is used for clamping a workpiece to be quenched; a spraying cooling device is arranged between the sensor and the workpiece clamp and is used for rapid cooling of the workpiece heated by the sensor; and a driving device is further arranged on one side of the L-shaped mounting plate, and the driving device is in transmission connection with the lead screw transmission mechanism and is used for driving the lead screw transmission mechanism to work. The high-frequency quenching and automatic cooling integrated machine has the beneficial effects that the quenching speed is high, the treatment efficiency is high, and thequenching quality is good.
Owner:KAZUO PENGDA CASTING

Switching device for a battery, and battery comprising said switching device

The present invention relates to a switching device 1 for a battery 2, the switching device 1 being activated by an acoustic resonance effect to interrupt an electric line of the battery 2 to the outside. The present invention further relates to a battery 2 having an electrically activated power switch 21 for interruption of an electric line of the battery 2 to the outside and at least one such switching device 1, the power switch 21 and the switching device 1 being connected in series.
Owner:ROBERT BOSCH GMBH

Water-based quenching liquid, preparation method thereof and application of water-based quenching liquid in quenching of elastic strip

The invention relates to the technical field of railway engineering product manufacturing, in particular to water-based quenching liquid, a preparation method thereof and application of the water-based quenching liquid in quenching of an elastic strip. The water-based quenching liquid comprises the following components in percentage by weight: 0.1 to 0.8 percent of sodium benzoate, 0.01 to 0.5 percent of sodium gluconate, 0.01 to 0.5 percent of phosphono carboxylic acid copolymer, 0.01 to 0.5 percent of triazole, 0.01 to 0.5 percent of sodium molybdate, 0 to 25 percent of sodium chloride, 0 to 25 percent of calcium chloride, 0 to 25 percent of sodium nitrate and the balance of water, wherein the contents of sodium chloride, calcium chloride and sodium nitrate are not 0 at the same time. By the adoption of the water-based quenching liquid, the quenching speed of the elastic strip can be increased, the hardness uniformity of a quenching core part is guaranteed, residual compressive stress is generated on the surface of the quenched elastic strip, generation and extension of hardening cracks are inhibited, and the water-based quenching liquid has the advantages of being safe and environmentally friendly.
Owner:BEIJING TIEKE SHOUGANG RAIL TECH CO LTD

Method for preparing high purity 4-chloro-5-methyl-7H-pyrrole [2,3-d] pyrimidine

The invention discloses a method for preparing high purity 4-chloro-5-methyl-7H-pyrrole [2,3-d] pyrimidine. A starting material 4-chloro-7H-pyrrole [2,3-d] pyrimidine is subjected to a bromination reaction and methylation; a crude product is recrystallized to obtain high purity 4-chloro-5-methyl-7H-pyrrole [2,3-d] pyrimidine. The method has mild and simple reaction conditions, low cost, high yield and simple operation, and is suitable for industrial production.
Owner:苏州科捷生物医药有限公司

Quenching and reading circuit for single photon avalanche diode imaging device

The invention aims at providing a quenching and reading circuit for a single photon avalanche diode imaging device, which is composed of three modules including a quenching circuit, a holding circuit and a reading circuit, wherein the quenching circuit is used for generating a pulse signal having the same frequency with an incident photon signal, the holding circuit is used for generating a reset signal, the phase of the reset signal is different from the phase of quenching output, the frequency of the reset signal is the same with the frequency of the quenching output, and the reading circuit is used for performing count processing on the quenching output pulse signal and outputting the signal in a linear and logarithmic mode. Quenching processing is performed on an avalanche diode after photon incidence by utilizing the quenching circuit, pulse signal output with the same frequency as incident photons is generated and directly sent into the reading circuit, the reading circuit selects to output a final result in a linear or a logarithmic mode according to the control of a plus signal, and simultaneously the quenching output pulse is delayed to keep the frequency unchanged and the phase changed to serve as the reset signal for controlling the staring or stopping of quenching.
Owner:NANJING UNIV OF POSTS & TELECOMM INST AT NANJING CO LTD

A heat treatment method for controlling heat treatment deformation of an inner ring gear

The invention provides a heat treatment method for controlling the heat treatment deformation of an internally toothed ring, which comprises the steps of: cleaning the internally toothed ring withoutdamages on detection surfaces and then drying the internally toothed ring; feeding the dried internally toothed ring into a heating chamber for nitrocementation; placing a cylindrical or annular mandrel in the internally toothed ring after the nitrocementation, the mandrel and the internally toothed ring being in interference fit; conducing electromagnetic induction quenching to the internally toothed ring equipped with the mandrel; tempering the quenched internally toothed ring gear, the mandrel being still assembled with the internally toothed ring during the tempering; and cooling the internally toothed ring to room temperature to separate the mandrel from the internally toothed ring. With adoption of the heat treatment method provided by the invention, the heat treatment process has high efficiency and good effect, and the quenching deformation of the internally toothed ring is avoided as much as possible, thereby ensuring the dimensional accuracy and roundness of the internally toothed ring. The method is especially applicable to the heat treatment process of internally toothed rings with a relatively large diameter and small thickness.
Owner:东华链条兴化有限公司

Squeegee rotary adjusting device for quenching treatment

The invention discloses a squeegee rotating device for quenching treatment, which comprises a bottom ring and a top ring, a number of support plates are arranged between the bottom ring and the top ring, a number of slots are arranged on the top ring, and the inner side wall of the bottom ring There are bumps, the bottom ring and the bumps are integrated, the bottom ring is provided with a chassis, and the chassis is set on the bumps; the chassis is provided with a fixed plate, and the fixed plate is provided with sleeves, and the sleeves are vertically arranged. The outer peripheral surface of the root of the tube is covered with a protective tube; the outer peripheral surface of the casing is covered with a plane bearing, and the outer peripheral surface of the plane bearing is covered with a protective sleeve. The invention can quickly quench the ink scraper through the quenching equipment, thereby greatly improving the efficiency of quenching the ink scraper.
Owner:SHANGHAI ZHAOYI ELECTRONICS TECH CO LTD

A device for liquid nitrogen injection experiments with double nozzles that improves quenching speed easily

The invention discloses a double-nozzle liquid nitrogen injection experiment device for simply and conveniently improving the quenching speed. The device comprises liquid nitrogen supply sources, theliquid nitrogen supply sources are connected with liquid nitrogen spray heads through liquid nitrogen conveying pipes, the liquid nitrogen spraying heads are arranged on the left side wall and the right side wall of a liquid nitrogen injection working chamber in a bilateral symmetry mode, and a sample clamping device and an induction heating device are arranged inside the liquid nitrogen injectionworking chamber. According to the device, the key components such as the induction heating device, the liquid nitrogen supply sources, a flow control unit, the liquid nitrogen conveying pipes, the liquid nitrogen injection working chamber, the sample clamping device and a temperature measuring thermocouple are skillfully designed and reasonably arranged, so that multiple aspects such as the liquid nitrogen flow rate, the flow rate, the cold speed measurement and the spraying uniformity can be accurately controlled correspondingly, and meanwhile, the problems that the cooling measuring speed and the quenching cooling speed are not enough, and the uniformity is poor can be solved.
Owner:GUIZHOU UNIV

Whole quenching device of circular track

The invention provides a whole quenching device of a circular track. The device is suitable for quenching of a circular track with an outer circle and can realize whole heating, whole liquid spray and completion of the quenching process. By adopting the device, the quenching quality is stable, the soft belt is avoided and the life of the track is greatly prolonged. The invention adopts the following technical scheme: the device comprises a liquid sprayer and a track sensor, wherein the liquid sprayer is a circular ring body; the circular ring body is provided with a hollow cavity inside; the liquid sprayer is connected with liquid inlet joints and connecting screw rods; the track sensor is installed in the inner circle cavity of the liquid sprayer; the inner circle of the liquid sprayer is provided with liquid spray holes on the whole circumference; the track sensor comprises at least five track sensing circles uniformly arranged on the circumference; the track sensing circles are installed on a fixed block and are communicated with each other; the fixed block is fixed on the liquid sprayer by a bolt; one end of the fixed block is provided with a liquid inlet and the other end of the fixed block is provided with a liquid outlet; and common pole plates are installed on the fixed block and are connected with the track sensing circles.
Owner:SHIYAN HENGJIN INDUCTION TECH CO LTD

Calculation method for positioning flashover path of multi-cavity structure

ActiveCN113533912AFast quenchingReduce the rate of lightning accidentsTesting dielectric strengthMechanical engineeringCalculation methods
The invention discloses a calculation method for calculating a positioning flashover path of a multi-cavity structure. The calculation method for positioning the flashover path of the multi-cavity structure comprises the following steps: acquiring an equivalent air gap distance according to a breakdown voltage in combination with a relation curve of a rod-rod electrode U50% and a gap distance; according to the number of the cavities and the equivalent air gap distance, performing data fitting and drawing a fitting curve; and according to the established fitting curve, fitting a relation formula between the number of the cavities and the air gap distance. According to the invention, the external series air gap distance can be set, the flashover path can be positioned, and the installation of the multi-cavity structure and the external series air gap can be guided. Thus, the flashover path is restrained in the cavity, the insulator string is prevented from flashover to damage the insulator, safe and reliable operation of the line is guaranteed, and the device has important significance in practical application.
Owner:云南电网有限责任公司德宏供电局 +1

An array single photon avalanche photodiode gain adaptive adjustment circuit

ActiveCN108681362BImplement Gain Consistency DetectionAvoid direct regulationElectric variable regulationCurrent mode controlHemt circuits
The invention discloses an array single photon avalanche photodiode gain self-adaptive adjustment circuit, comprising: a current bias circuit for providing equal current for each SPAD pixel unit; a current monitoring circuit composed of a current mirror circuit for Judging its working state according to the monitored SPAD pixel unit current, and outputting different voltage signals for gain control of the SPAD pixel unit and as the input signal of the active quenching circuit; the active quenching circuit is used to monitor the output voltage of the circuit according to the current The signal generates and outputs a pulse signal to control the conduction of the quenching tube to quench the avalanche signal and prepare for the arrival of the next detection photon. The invention adopts a current mode control method to adaptively adjust the reverse bias voltage of the SPAD, overcomes the disadvantage of complex control in the traditional voltage mode mode, is suitable for array application, is easy to expand, and realizes array single photon avalanche photodiode gain consistency detection.
Owner:SOUTHEAST UNIV

Wear-resistant steel ball quenching equipment

The invention proposes wear-resistant steel ball quenching equipment. The wear-resistant steel ball quenching equipment comprises a quenching pool, a first ball conveying pipe, a second ball conveying pipe, a cooling box and a conveying device, wherein a first end of the first ball conveying pipe is arranged at the outer side of the upper side of the quenching pool, and a second end is connected with a first end of the second ball conveying pipe; the second ball conveying pipe is arranged at the bottom of the quenching pool; a steel ball outlet is formed in a second end of the second ball conveying pipe; multiple dust outlet pipes are arranged at the lower part of the second ball conveying pipe along a steel ball output direction in sequence, and penetrate through the bottom of the quenching pool; the dust outlet pipes at the front section and the back section of the second ball conveying pipe are respectively communicated with a first liquid colleting part and a second liquid collecting part; a first filter and a second filter are respectively arranged in the first liquid collecting part and the second liquid collecting part; the first liquid collecting part and the second liquid collecting part are respectively communicated with the cooling box; the cooling box is communicated with the quenching pool; and one end of the conveying device is arranged below the steel ball outlet, and the other end is arranged at the outer side of the upper side of the quenching pool. The wear-resistant steel ball quenching equipment is uniform in quenching, easy for through hardening and fast in speed, obviously improves the quenching effect, and promotes the quenching efficiency.
Owner:NINGGUO SOUTHERN WEAR RESISTANT MATERIALS

Atmosphere controlled quenching device for magnetically buffering fall of furnace body

The invention discloses an atmosphere controlled quenching device for magnetically buffering fall of a furnace body, and belongs to the technical field of metallurgical equipment. A vertical guide rail is arranged in a case, a guide shoe 11 capable of sliding on the vertical guide rail is arranged on three groups of fixed supporting plates on the vertical guide rail, and a cooling chamber and thefurnace body connected with the cooling chamber are fixed in two cavities formed among the three groups of fixed supporting plates from top to bottom respectively; fixed brackets are arranged at the upper end and the lower end of the cooling chamber; the furnace body and the water-cooled cooling chamber connected together are connected with a traction steel wire of a tractor used for guiding the device to move upwards and arranged at the top of equipment; and a magnet A is arranged at the bottom of the furnace body. A magnet B for generating a repulsive force for retarding free fall of the furnace body and the cooling chamber together with the magnet A is arranged relatively on the same pole as the magnet A at the bottom of the case. By adopting natural fall of the furnace body and the water-cooled cooling chamber and shock absorption stop of the permanent magnets, the atmosphere controlled quenching device has low investment, is easily implemented, and has high quenching speed.
Owner:BEIJING UNIV OF TECH

Active quenching and resetting circuit and detection system

The invention provides an active quenching and resetting circuit, and the circuit is characterized in that the circuit comprises a single photon avalanche diode which is used for receiving an optical signal and generating an avalanche current; the initialization module is used for initializing the single photon avalanche diode; the reset module is used for resetting the single photon avalanche diode; the clamping module is used for clamping the single photon avalanche diode; and the threshold value detection unit is used for detecting the cathode voltage of the single photon avalanche diode, feeding back a detected signal to the reset module and controlling the starting of the reset module. The SPAD has the beneficial effects that the SPAD can be rapidly quenched and reset by setting the threshold detection unit and adjusting the reset time of the reset module, and when the threshold detection module detects that the voltage is reduced below the threshold, the reset module is controlled to reset, so that quenching and reset can be adaptively adjusted.
Owner:NINGBO ABAX SENSING ELECTRONICS TECH CO LTD

Poured-in type quenching technology and quenching equipment

The invention belongs to the field of plate spring preparation, and in particular relates to an influx type quenching process, that is, the plate spring is placed in an empty quenching tank, and the plate spring is hot-pressed with a quenching fixture, and then the quenching medium is rapidly injected from the upper part. pouring into the quenching tank, on the one hand, by using a large amount of low-temperature, continuously pouring, and fast-flowing quenching medium, the metallographic structure of the obtained leaf reed after quenching is made uniform, and the grains are made finer, so that the structure is formed from The transformation from austenite to martensite is faster and more complete, which prolongs the fatigue life of the leaf spring. On the other hand, it improves the quenching speed and production efficiency, and shortens the product production cycle. The present invention also provides a quenching equipment used in the quenching process, which has a compact structure, saves space, replaces manual operation, and realizes mechanized production, which not only saves manpower, avoids potential safety hazards, but also ensures quenching efficiency , so as to meet the needs of industrial production.
Owner:SHANDONG AUTOMOBILE SPRING FACTORY ZIBO CO LTD

Synthesis method of C-glycoside derivative

ActiveCN113248464AAvoid the problem of impurity growthInhibit growthOrganic chemistrySodium bicarbonateGlycoside
The invention relates to the technical field of medicinal chemistry, and particularly discloses a synthesis method of a C-glycoside derivative. The method comprises the following steps: adding a compound shown in formula (II) and triethyl silane into dichloromethane, carrying out nitrogen protection, carrying out dry ice acetonitrile bath cooling to-35 DEG C to -45 DEG C, dropwise adding a 20% boron trifluoride acetonitrile complex, and carrying out heat preservation at -35 DEG C to -45 DEG C to carry out a synthesis reaction of the C-glycoside derivative shown in formula (I); and then, dropwise adding the reaction system into a sodium bicarbonate aqueous solution for quenching reaction; The quenching reaction mode in the existing synthesis process is improved, the reaction can be rapidly quenched, the quenching time is short, the operation is easy, and the problem of impurity III growth caused by reaction system temperature rise can be effectively avoided.
Owner:BEIJING HUIZHIHENG BIOTECHNOLOGY CO LTD +1

A kind of synthetic method of c-glycoside derivative

ActiveCN113248464BAvoid the problem of impurity growthInhibit growthOrganic chemistrySodium bicarbonateEthyl group
The invention relates to the technical field of medicinal chemistry, and specifically discloses a synthesis method of C-glycoside derivatives. Add the compound of formula (II) and triethylsilane into dichloromethane, under nitrogen protection, cool down in a dry-ice acetonitrile bath to -35°C~-45°C, add 20% boron trifluoride acetonitrile complex dropwise, at -35°C~ Carry out the synthesis reaction of NaC-glycoside derivatives shown in formula (I) by incubating at -45°C; after that, add the reaction system dropwise into aqueous sodium bicarbonate solution to quench the reaction. The invention improves the way of quenching reaction in the existing synthesis process, can quickly quench the reaction, has short quenching time, is easy to operate, and can effectively avoid the problem of impurity III growth caused by the temperature rise of the reaction system.
Owner:BEIJING HUIZHIHENG BIOTECHNOLOGY CO LTD +1
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products