The invention discloses a pressure head automatic quick-change device. The pressure head automatic quick-change device comprises a pressure head locking mechanism, a pressure head and a quick-change auxiliary intervention mechanism, wherein the pressure head locking mechanism is provided with a grabbing main body and a floating locking sleeve. A pressure head quick-change main shaft is arranged atthe pressure head, matched with the pressure head locking mechanism, the pressure head quick-change main shaft and the pressure head form a whole, the quick-change auxiliary intervention mechanism isprovided with a quick-change intervention plate, and a quick-change intervention plate is powered by an air cylinder and is connected with a floating locking sleeve of the pressure head locking mechanism. According to the structural design, not only can the error caused by machining and assembling be compensated, but also the device can be compatible with multiple types of press-fitting, and hasthe advantages of being convenient to install and debug, reducing the risk, improving the production time and the like. According to the pressure head automatic quick-change device, the pressure headscorresponding to the corresponding parts can be conveniently replaced when the pressure heads of multiple types of press-in parts are assembled in the same machine type and in the same station, so that the production rhythm can be further compressed, and the device can be compatible with multiple types of press-fitting, and has the advantages of being simple in structure, convenient to install and debug, and flexible in equipment installation and debugging.