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This invention discloses a feature denoising distillation method guided by Logit information, belonging to the field of model compression technology. The method includes: first, encoding the discriminative direction of the teacher classifier using a Logit discriminative encoder to ensure feature alignment along the semantic direction; then, constructing a feature denoising mask to emphasize the teacher's target attention region while suppressing redundant background responses, thereby achieving spatial-level denoising in the feature space. Finally, a feature denoising distillation framework guided by Logit information is designed to achieve model compression. This invention provides explicit semantic direction guidance through a Logit discriminative encoder, suppresses background and noise activation through a feature denoising mask, and integrates both into the intermediate feature distillation process between the teacher and student models. It systematically solves the problems of lack of Logit semantic guidance, severe background noise interference, and insufficient focus of the distillation target in existing technologies, achieving high-precision and highly compatible model compression and knowledge transfer.

This invention discloses a AIPL1 A gene mutation-related congenital amaurosis animal model, its construction method, and its application. The method includes: S1, constructing a humanized... AIPL1 S2, a homologous recombination vector with a point mutation of c.421 C>T (p.Q141X) knocked in; S3, Cas9 mRNA, gRNA1, gRNA2 and the homologous recombination vector are injected into animal zygotes to perform homologous recombination, resulting in transfected zygotes; S4, the transfected zygotes are transplanted into the uterus of pseudopregnant animals to reproduce offspring, and offspring are selected from the offspring. AIPL1 Homozygous animals with the c.421 C>T (p.Q141X) point mutation were obtained, thus yielding the aforementioned... AIPL1 A gene mutation-related congenital amaurosis animal model. The animal model of this invention exhibits the clinical phenotype of Leber congenital amaurosis type 4 (LCA4) from 12 days after birth; while heterozygous mice do not show a significant phenotype, consistent with... AIPL1 The clinical phenotype and inheritance pattern of LCA caused by the c.421 C>T (p.Q141X) gene mutation demonstrate the effectiveness and reliability of the animal model of this invention, providing a basis for understanding the genetic model of LCA. AIPL1 Animal models provide a reliable basis for studying the disease mechanisms and drug screening of mutation-related LCA.