The invention discloses a method for rapidly establishing three-dimensional fine thermos-hydraulic calculation models for primary side systems of large-scale natural circulation vapor generators in nuclear power plants under certain heat transfer tube blocking accident conditions. The method comprises the following steps of: 1, carrying out complete primary side hydraulic analysis on a vapor generator so as to analyze a flow distribution law at a tube plate; 2, selecting a tube blocking scheme according to a result of the last step; 3, determining a tube blocking share and a tube blocking position; 4, carrying out geometric simplification and overall geometric modeling on a plurality of heat transfer tubes in the real vapor generator; 5, dividing preliminary calculation nodes; 6, establishing a tube blocking equation to tracing marked control areas, and carrying out calculation domain grid marking on the control areas by adoption of a network marking method so as to realize a tube blocking function; and 7, carrying out blocking condition calculation by adoption of a preliminarily established model and analyzing the precision of the result, and if a requirement is satisfied, considering that the modeling is completed, and otherwise, returning to the step 5 to encrypt the calculation nodes until the model satisfies the calculation precision requirement.