The invention discloses a privacy protection method oriented to large-scale graph data dissemination. The privacy protection method specifically comprises the steps of 1, uniformly dividing original graph data into multiple subsidiary blocks; 2, reading cut connection sides, comparing node degrees of the two ends of each cut connection side, newly adding noise nodes in a subsidiary block of each node with a large node degree, and reserving the cut connection sides through a ligature of the corresponding node with the large node degree and the corresponding noise node; 3, constructing an isomorphism block matrix, wherein subsidiary block structure information is compared with the isomorphism block matrix, and isomorphism is conducted in the mode of adding the noise sides to complete graph data anonymous protection. The time needed for the overall graph data anonymous protection is lowered by one order of magnitudes, and the efficiency of an anonymization process is achieved; finally ananonymous graph satisfies a k anonymous mechanism, and the safety of anonymization is achieved. By means of the privacy protection method oriented to the large-scale graph data dissemination, it is guaranteed that the balance performance of the anonymous graph among usability, safety and efficiency is improved by a large margin.