21 results about "Poly-N-vinylcaprolactam" patented technology

The invention discloses a composite additive for a water-soluble quenching medium and a preparation method of the composite additive. The composite additive is prepared from the following components in parts by weight: 10 to 20 parts of polyisobutene maleic anhydride, 7 to 20 parts of polyvinyl caprolactam, 1.5 to 3.5 parts of polyacrylamide, 5 to 9 parts of organic alcohol amine, 0.5 to 0.7 part of an antirust agent, 0.5 to 0.9 part of a bactericidal mildew preventive, 0.3 to 0.5 part of a de-foaming agent and 30 to 50 parts of water. The composite additive can be efficiently mixed and dissolved with a traditional water-soluble quenching medium, the water-soluble quenching medium is promoted to achieve control over the low-temperature cooling speed and the lower characteristic temperature in the quenching technological process, and therefore the application range of the water-soluble quenching medium is widened, the quality of a quenched workpiece is improved, and the service life of the workpiece is prolonged. The composite additive disclosed by the invention not only solves the problem of low characteristic temperature of the existing water-soluble quenching medium, but also can enable the water-soluble quenching medium to keep proper maximum cooling speed and high characteristic temperature, and finally shows the cooling performance close to that of quenching oil.

The application discloses a preparation method of a semi-interpenetrating network hydrogel based on an amino-succinimide ring-opening reaction, which comprises the following steps: firstly, a hydrophilic compound containing amino groups, such as trishydroxymethylaminomethane, is used to modify polysuccinimide to obtain water-soluble polysuccinimide polymer; N-vinylcaprolactam and 3-mercaptopropionic acid are reacted to obtain poly-N-vinylcaprolactam polymer with terminal carboxyl groups; and the polymer is used to graft hydroxypropyl methyl cellulose to obtain macromolecular hydroxypropyl methyl cellulose derivative. The water-soluble polysuccinimide, the polymer containing amino groups and the hydroxypropyl methyl cellulose derivative are dissolved in water, and the amino-succinimide ring-opening reaction is utilized to obtain the hydrogel; the hydrogel is soaked in water to remove uncrosslinked components; and after drying, the semi-interpenetrating network hydrogel is obtained. The preparation process is simple, the conditions are mild, and the reaction speed is fast; and the prepared hydrogel has pH / temperature sensitivity and can be used in many fields such as tissue engineering, drug release, water treatment and the like.

The invention discloses a temperature response type antibacterial packaging fresh-keeping film as well as a preparation method and application thereof, and belongs to the technical field of fruit packaging fresh-keeping. The preparation method comprises the following steps: mixing polyvinyl alcohol (PVA) and polyvinyl caprolactam (PNVCL), stirring and dissolving to obtain a shell solution; the preparation method comprises the following steps: mixing polylactic acid (PLA) and hexafluoroisopropanol, stirring and dissolving to obtain a PLA solution, adding cinnamon essential oil (CEO), and uniformly stirring to obtain a core layer solution; degassing and standing; and performing coaxial electrostatic spinning on the shell layer solution and the core layer solution to obtain the fresh-keeping film. The fresh-keeping film has good hydrophilicity, antibacterial property and oxidation resistance, can intelligently respond to environment temperature change to realize CEO slow release, can effectively delay softening, decaying and deterioration of the picked waxberries, and remarkably prolongs the fresh-keeping period.

The present application relates to a kind of Williamson method preparation LCST controllable temperature-sensitive lignin and preparation method and application.The preparation method of the Williamson method preparation LCST controllable temperature-sensitive lignin, comprising the following steps: the activation of lignin sulfonate;N-vinyl caprolactam modification: initiator, N-vinyl caprolactam, modifier are dissolved in solvent one after heating, namely obtained;Temperature-sensitive lignin preparation: after the activation of lignin sulfonate is dissolved in solvent two, modified poly N-vinyl caprolactam, pH regulator, catalyst, heating is obtained.The present application utilizes the mixed solution of urea and sodium hydroxide to activate lignin sulfonate, improves the content of phenolic hydroxyl in lignin sulfonate;N-vinyl caprolactam is modified, and mercapto radical effectively attacks the olefin bond of N-vinyl caprolactam;Using Williamson ether reaction, the halogen in modified poly N-vinyl caprolactam is combined with the phenolic hydroxyl in activated lignin sulfonate to form ether.

The present invention relates to a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PCL S-PAC-PEG S) micelle in which osimertinib, etoposide, and docetaxel are encapsulated, and used thereof. Specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer, wherein osimertinib, which is a target therapeutic agent, and etoposide and docetaxel, which are both anticancer chemotherapeutic drugs, are encapsulated in a Soluplus® polymer to form micelles, whereby anticancer activity can be effectively induced through an improvement in the solubility of the poorly soluble drug in water and a synergistic action between the drugs. The pharmaceutical composition for cancer treatment according to the present invention enables effective solubilization of osimertinib, etoposide, and docetaxel by encapsulating the poorly soluble drugs in micelles formed using the PCL-PVAc-PEG (Soluplus®) polymer, and thus can be advantageously used as an intravenous injection. With the advantage of avoiding first-pass metabolism in the liver, unlike oral dosage forms, intravenous injection can reduce unnecessary loss of drugs and also increase bioavailability compared to oral dosage forms, and thus is an effective administration method capable of expecting a high effect with the same amount of drugs. Therefore, development of such a formulation allows effective administration of osimertinib, etoposide, and docetaxel. In addition, the composition of the present invention can effectively treat non-small cell lung cancer having an EGFR-sensitive mutation while preventing the development of anticancer drug resistance, which can be caused by single drug administration, by using a targeted therapeutic agent and chemotherapy in combination. Furthermore, the composition of the present invention employs a biocompatible polymer as a material of the micelle and thus has an advantage of being safe for the human body. Moreover, by combining osimertinib, etoposide, and docetaxel at a specific molar ratio and encapsulating same in Soluplus® micelles, the composition of the present invention has excellent encapsulation efficiency of three kinds of drugs and has high monodispersibility having a consistent particle size of 50-60 nm. Thus, the composition can maintain consistent product quality and has excellent formulation stability.

This invention discloses a functionalized graphene quantum dot fluorescent ink composition and its preparation method, belonging to the technical field of anti-counterfeiting printing functional materials. The ink composition, based on a total weight of 100 parts, comprises 0.8-2.5 parts of graphene quantum dots co-modified with phosphonic acid and poly(N-vinylcaprolactam), 25-40 parts of an aqueous polyurethane dispersion, 0.5-1.5 parts of benzo-15-crown-5-carboxylic acid, 0.3-0.8 parts of a dispersant, 0.2-0.6 parts of a leveling agent, 0.1-0.3 parts of a defoamer, and the balance being deionized water. The quantum dots are prepared by a one-step hydrothermal method using citric acid, N-vinylcaprolactam, and vinylphosphonic acid as core raw materials in the presence of an initiator and a crosslinking agent. The ink of this invention simultaneously possesses photoluminescence, temperature response, and Fe... 3+ It features a triple anti-counterfeiting function with specific identification, and there is a synergistic enhancement effect between temperature sensitivity and ion response. At the same time, the ink has excellent storage stability and printability, making it suitable for high-end anti-counterfeiting fields.

The invention provides a thermo-sensitive block surfactant as well as a preparation method and application thereof, and belongs to the technical field of macromolecular surfactants. The surfactant comprises a chain segment A and a chain segment B, the chain segment A is polyvinylpyrrolidone, and the chain segment B is polyvinyl caprolactam. When the ratio of the two segments is within a certain range, the block surfactant shows hydrophilicity below the LCST temperature, when the temperature rises to above the LCST temperature, the hydrogen bond of the chain segment B is broken, the chain segment B shows hydrophobic property and lipophilicity and gathers into micelles, the oil phase is solubilized in the micelles, so that an emulsion state is formed, and after the temperature is reduced, the chain segment B can recover the hydrogen bond with water, so that the oil phase is solubilized in the micelles. The demulsification process can be realized in a short time. The temperature-induced reverse response system can be applied to the fields of temperature-controlled oil-water systems, chemical synthesis, oilfield chemistry and the like.

The invention provides a sustained-release antibacterial ophthalmic postoperative dressing and a preparation method thereof, and belongs to the technical field of drug sustained release. A core-shell structure is formed by coating a medicine with calcium alginate, and a gel network is prepared by crosslinking poly (N-vinylcaprolactam) microgel and sodium alginate. Sodium alginate can form a moist environment on the surface of a wound and promote healing due to the high water absorption of sodium alginate, forms a gel barrier through calcium ion exchange, delays drug release, complements with the temperature sensitivity of poly (N-vinylcaprolactam) and prolongs the drug action time. The chitosan grafted on the outer layer has natural broad-spectrum antibacterial property, can inhibit early infection by destroying bacterial cell membranes, and reduces the risk of bacterial colonization in the early stage after operation. Dynamic regulation and control of drug release, double antibacterial protection and biocompatibility optimization are achieved, and the preparation is particularly suitable for scenes with strict requirements for precise treatment and high safety after ophthalmology.

Solid dispersion comprising 20-40 wt % of etrumadenant and 60-80 wt % of a polymer selected from HPMCAS, PVP-PA, CAP, HPMC E3, HPMCP, PVP and polyvinyl caprolactam-polyvinyl acetate-PEG graft copolymer. A process for preparing said composition by spray drying. Said composition for use in the treatment of cancer.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a method for purifying a crude chloroacetic acid product. The method comprises the following steps: S1, impregnating activated carbon with chloropalladic acid to prepare a catalyst precursor; the preparation method comprises the following steps: blending a catalyst precursor, a dispersing agent, a reducing agent, poly (N-vinyl caprolactam) and (S, S)-(+)-N, N '-bis (3, 5-di-tert-butyl salicylidene)-1, 2-cyclohexanediamine, carrying out a reduction reaction to prepare a palladium-carbon catalyst, and passivating to prepare a passivated palladium-carbon catalyst; s2, the heated crude chloroacetic acid product and hydrogen are introduced into a micro-interface generator to be mixed, then hydrogenation reaction is carried out under the action of a passivated palladium-carbon catalyst, gas-liquid separation and rectification are carried out after the reaction is completed, and the chloroacetic acid product is prepared. By improving the problems of insufficient selectivity and conversion rate of dichloroacetic acid impurities in the chloroacetic acid crude product purified by the existing palladium-carbon catalyst, the content of the dichloroacetic acid impurities in the chloroacetic acid crude product after catalytic hydrogenation is effectively reduced.

The invention discloses a preparation method of a drug solid solution, which uses a polyethylene glycol copolyvinyl caprolactam-vinyl acetate segmented copolymer as an auxiliary material to significantly improve the solubility and bioavailability of an indissolvable drug active component. The drug solid solution prepared by mixing the indissolvable drug active component with the plasticizer, the flow aid and the polymer auxiliary material and processing through a hot melt extrusion process shows excellent solubilization and crystal inhibition effects. The solubility of the medicine can be remarkably improved, and the growth of medicine crystals can be effectively inhibited, so that the curative effect and the stability of the medicine are improved.

The invention relates to a sodium acetate-containing hydrate inhibitor for guaranteeing the flow of a carbon dioxide conveying pipeline, which comprises the following components in percentage by mass: 50-60wt% of sodium acetate, 25-30wt% of methanol, 0.01-1wt% of poly (N-vinyl caprolactam), 0.01-1wt% of polyoxyethylene sorbitan monooleate and the balance of a sodium chloride solution serving as a solvent after mixing the sodium acetate, the methanol, the poly (N-vinyl caprolactam), the polyoxyethylene sorbitan monooleate and the sodium chloride solution serving as the solvent. And 0.01 to 0.1 wt% of polyoxyethylene sorbitan monooleate. The sodium acetate, the methanol, the poly (N-vinyl caprolactam) and the polyoxyethylene sorbitan monooleate are compounded for use, so that the effect of a single inhibitor is enhanced, the application range is wider, a better inhibition effect is achieved while the use concentration of the methanol is reduced, and the generation of the carbon dioxide hydrate can be better inhibited. The mixed use reduces the cost of the inhibitor, reduces the use amount of the mixture, and weakens the toxicity and pollution of the inhibitor.

The invention relates to the technical field of pharmaceutical preparations, and provides a non-alcohol film-forming preparation for skin application, a preparation method and a pharmaceutical composition containing the preparation, the non-alcohol film-forming preparation comprises a copolymer of poly (vinyl caprolactam) and poly (butyl acrylate), and a copolymerization reaction system of the copolymer comprises the following components in parts by mass: 1-10 parts of a comonomer, 1-10 parts of a comonomer, 1-10 parts of a comonomer and 1-10 parts of a comonomer. Comprising the following raw materials: comonomers: 1 part of N-vinyl caprolactam and 1-3 parts of butyl acrylate; 4-6 parts of a cross-linking agent; 4-6 parts of a surfactant; 1-2 parts of a buffering agent; 1-2 parts of an initiator; and 80-90 parts of a medium. The defects in the prior art are overcome, alcohol is prevented from being used as a solvent, the risk of skin allergy is reduced, the production safety is improved, and meanwhile, the good film forming effect of the preparation is taken into account.

The invention relates to a bionic responsive polymer nanogel material as well as a preparation method and application thereof, the described nanomaterial takes poly (N-vinylcaprolactam) nanogel as a carrier, the surface of the nanogel is modified with indocyanine green, the interior of the nanogel is loaded with a drug, and finally the nanogel is coated with an exosome or a cell membrane extracted from cancer cells. The bionic responsive nanogel disclosed by the invention has a homologous targeting function, can improve the cancer cell uptake efficiency, can release drugs in a tumor microenvironment in a responsive manner, effectively reduces the non-specific toxic and side effects of the drugs, remarkably inhibits tumor growth through the combined action of mild photothermal therapy and chemotherapy, and has a good application prospect. After the nanogel is injected into the body of a mouse through tail vein, the ICG can realize thermal imaging and fluorescence imaging in the body by virtue of the excellent photo-thermal characteristic and fluorescence characteristic of the nanogel. Therefore, the method has potential clinical application value.

The present disclosure relates to compositions comprising admixtures of poly (N-vinyl caprolactam)-poly (vinyl acetate)-poly (ethylene glycol) graft copolymer and an aqueous solution which includes i) a buffer comprising a weak acid and its conjugate base provided that at least one pKa of the weak acid is from 3 to 7.2 and / or ii) one or more sugar alcohols. The content of the copolymer in the admixture is from 12.5 wt-% to 15 wt-%. These compositions are pipetable and injectable at room temperature but form a gel at body temperature. The disclosure relates also to pharmaceutical formulations comprising the composition, and use of the composition as a thermoresponsive formulation for active pharmaceutical ingredients.

The invention provides a microbial agent for decomposing pollutants as well as a preparation method and application of the microbial agent. The microbial agent for decomposing the pollutants is prepared from the following raw materials in parts by weight: 40 to 80 parts of compound bacteria, 15 to 25 parts of an enzyme preparation, 10 to 15 parts of a growth matrix, 3 to 6 parts of nutrient elements, 1 to 3 parts of a stress resistance regulator, 0 to 0.15 part of azide-red-sphingosine and 0 to 0.05 part of polyvinyl caprolactam. Wherein the compound bacteria are one or more of bacillus megaterium, bacillus subtilis, bacillus pumilus, pseudomonas fluorescens, bacillus licheniformis and bifidobacterium pseudolongum; the stress resistance regulator is a mixture of ethoxylated castor oil and dodecyl hydroxyl poly (oxy-1, 2-ethyoxyl). The microbial agent for decomposing pollutants provided by the invention is less affected by salt components and toxic substances in wastewater, can still realize higher decomposition efficiency in an environment with high salt content and toxic substances, and has a good treatment effect on petrochemical wastewater.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an ophthalmic sustained-release gel preparation containing a block copolymer and a preparation method of the ophthalmic sustained-release gel preparation. The preparation comprises a polyethylene glycol copolyvinyl caprolactam-vinyl acetate block copolymer, an active drug, a polycaprolactone-polyethylene glycol-polycaprolactone triblock copolymer, a mucous membrane penetration enhancer, an antioxidant, an osmotic pressure regulator, a pH regulator, a preservative and water for injection. The preparation method comprises the following steps: firstly pretreating the matrix, then treating the medicine and refining, then mixing the medicine and the matrix in stages, sequentially adding the auxiliary materials and dissolving, regulating the system to a proper state, standing and curing, and finally filtering, carrying out gradient cooling and carrying out sterile filling. The preparation can be used for treating eye diseases such as glaucoma and intraocular hypertension, and has the advantages of continuously and stably releasing medicines, prolonging the retention time of eyes and improving the medication compliance of patients; the preparation method is controllable in operation and easy to reproduce, can stably guarantee the quality of the preparation, and is suitable for industrial production.

The invention provides a stretchable wire and a preparation method and application thereof, and belongs to the technical field of flexible electronics, and the stretchable wire comprises a substrate layer, a middle layer and a packaging layer which are stacked; the middle layer comprises a circuit, the circuit is composed of conductive ink, and the conductive ink comprises liquid metal and an adhesive agent; the adhesive agent is at least one of poly (N-vinylcaprolactam) and carbomer. The liquid metal and the adhesive agent form the conductive ink, hydroxyl and / or carboxyl in the adhesive agent can form chemical bonds with an oxide layer of the liquid metal, and the adhesive agent is interspersed and entangled with molecular chains of the substrate layer, the middle layer and the packaging layer to form a cross-linked structure. And the binding force between the conductive ink and the substrate layer, between the intermediate layer and the packaging layer is improved, so that the conformal deformation capability between the liquid metal and the substrate layer, between the intermediate layer and the packaging layer is further improved.

The invention relates to a preparation method of a temperature-sensitive poly (N-vinylcaprolactam) grafted titanium dioxide hollow sphere catalyst with high catalytic activity. The method comprises the following steps: preparing titanium dioxide hollow spheres, synthesizing ammonia functionalized titanium dioxide hollow spheres from the titanium dioxide hollow spheres, and synthesizing aldehyde group functionalized titanium dioxide hollow spheres from the ammonia functionalized titanium dioxide hollow spheres; the preparation method comprises the following steps: introducing hydrogen chloride gas into 1, 4-dioxane until the pH value is 5, adding N-vinyl caprolactam, azodiisobutyronitrile and mercaptoethylamine, carrying out uniform ultrasonic dispersion, adding the aldehyde group functionalized titanium dioxide hollow spheres, carrying out uniform ultrasonic dispersion, stirring at 25 DEG C in a nitrogen environment, heating to 68 DEG C, and carrying out reflux stirring to obtain a crude product; ultrasonically dispersing the crude product in an ammonia water solution, stirring, centrifuging, washing, and drying in vacuum to obtain PNVCL-coated TiO2-HSs. The catalyst has the advantages of high initial catalytic activity and good recyclability.

The application relates to a sodium acetate hydrate inhibitor containing sodium acetate for carbon dioxide conveying pipeline flow guarantee, which comprises sodium acetate, methanol, poly (N-vinyl caprolactam), polyoxyethylene sorbitol monooleate, and the mass percentage concentration of the four after being mixed with a sodium chloride solution as a solvent is as follows: sodium acetate 50-60 wt%, methanol 25-30 wt%, poly (N-vinyl caprolactam) 0.01-1 wt%, and polyoxyethylene sorbitol monooleate 0.01-0.1 wt%. In the application, the composite use of sodium acetate, methanol, poly (N-vinyl caprolactam) and polyoxyethylene sorbitol monooleate enhances the effect of a single inhibitor, the use range is more extensive, a better inhibiting effect is achieved while the methanol use concentration is reduced, carbon dioxide hydrate generation can be better inhibited, the inhibitor cost is reduced by mixed use, the amount of the mixture is reduced, and the toxicity and pollution of the inhibitor are weakened.

The present invention discloses a composition of serum-free medium and a culture method suitable for culturing hematopoietic stem cells.SOLUTION: In accordance with the present invention, there is provided a method of culturing hematopoietic stem cells, the method comprising contacting hematopoietic stem cells with a polyalkylene glycol modified by a copolymer of polyvinyl caprolactam and polyvinyl acetate blocks.SELECTED DRAWING: None