The invention relates to novel application of botulinum neurotoxin serotype A, namely novel application in preparing a medicine for treating raynaud syndrome. The botulinum neurotoxin serotype A is easy to use for operation, low in cost, safe and small in pain when used for treating raynaud syndrome, can overcome the defects that the medicine acts to blood vessels of a whole body in a general oral, intramuscular or intravenous administration, the dose is difficult to hold, the side effect is high and the like, and can also overcome the defects of large surgical wound, more complications and high relapse rate of surgical treatment, so that the application is an innovation to various traditional treatment means ideally and methodologically.