36 results about "Sugar transport" patented technology

An agent for increasing the sugar-transporting capacity and an agent for preventing and / or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.

The present invention provides a lactam compound, a sugar transport enhancement agent containing this compound as an active ingredient, an agent for the prevention and / or treatment of diabetes mellitus, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macrovascular disease, glucose tolerance anomaly, obesity and the like. In addition, the present invention also provides a preparation method for the novel lactam compound, and a preparation intermediate thereof.

Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.

This invention relates to the production of succinic acid and other chemicals derived from phosphoenolpyruvate (PEP) by fermentation with a microorganism in which the fermentation medium contains one or more sugars, and in which one or more of the sugars is imported into the cell by facilitated diffusion. As a specific example, succinic acid is produced from a glucose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize glucose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and / or a salt of succinic acid) at a commercial scale using feedstocks that include, for example, glucose, fructose, or sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of glucose or fructose into the parental strains. The genes involved in the transport and metabolism of glucose or fructose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the efficiency of sugar transport and metabolism by strains already known to have some ability for glucose utilization in biological fermentations.

This invention relates to the production of succinic acid and other chemicals derived from phosphoenolpyruvate (PEP) by fermentation with a microorganism in which the fermentation medium contains one or more sugars, and in which one or more of the sugars is imported into the cell by facilitated diffusion. As a specific example, succinic acid is produced from a glucose-containing renewable feedstock through fermentation using a biocatalyst. Examples of such a biocatalyst include microorganisms that have been enhanced in their ability to utilize glucose as a carbon and energy source. The biocatalysts of the present invention are derived from the genetic manipulation of parental strains that were originally constructed with the goal to produce one or more chemicals (for example succinic acid and / or a salt of succinic acid) at a commercial scale using feedstocks that include, for example, glucose, fructose, or sucrose. The genetic manipulations of the present invention involve the introduction of exogenous genes involved in the transport and metabolism of glucose or fructose into the parental strains. The genes involved in the transport and metabolism of glucose or fructose can also be introduced into a microorganism prior to developing the organism to produce a particular chemical. The genes involved in the transport and metabolism of sucrose can also be used to augment or improve the efficiency of sugar transport and metabolism by strains already known to have some ability for glucose utilization in biological fermentations.

Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided is a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.

The invention discloses a rice sugar transport gene OsMST1 and a sugar transporter encoded by the rice sugar transport gene OsMST1. Overexpression of the rice sugar transport gene OsMST1 in rice can significantly increase the yield of rice per plant, and the yield of a plot can be increased by 15-16 %, the seed setting rate and yield of rice can be significantly reduced after the mutation / knockout, and the yield of the plot can be reduced by 20‑22%; by affecting the transportation and distribution of photosynthetic products, it can affect the yield of rice, but has no effect on fertility; for Enhance the transport and distribution capacity of photosynthetic products through genetic improvement of varieties, and provide a realistic basis for continuous improvement of rice yield. The invention also discloses the application of the rice sugar transport gene OsMST1 and its sugar transporter in cultivating high-yield crops, which can rapidly and effectively increase the yield of crops. The invention also discloses several PCR amplification primers of rice sugar transport gene OsMST1, which can effectively and quickly amplify the gene OsMST1 from rice cDNA.

The invention discloses the application of the rice blast fungus gene MoHXT2 in regulating the plant sugar transport function. The present invention finds that the transporter encoded by MoHXT2 accepts a variety of sugars as substrates, that is, the MoHXT2 gene is a hexose transporter of Magnaporthe grisea. After knocking out MoHXT2 using the CRISPR / Cas9 gene knockout system, the melanin content of the mutant hyphae is found The pathogenicity was significantly reduced, and phlorizin could inhibit the transport of hexose by MoHXT2, thereby inhibiting the growth of Magnaporthe oryzae. Therefore, the MoHXT2 gene can be used to regulate plant sugar transport function, regulate the pathogenicity of Magnaporthe grisea and regulate the growth and development of Magnaporthe grisea, and it can also be used as a drug target for new pesticides, providing a more reliable direction for the synthesis of targeted fungicides .