The invention discloses
design synthesis and application performance of a novel D-A-D organic near-
infrared tumor therapy reagent based on diketopyrrolopyrrole. The
reagent provided by the invention is mainly obtained by Suzuki
coupling reaction of 3, 6-bis(thieno[3, 2-c]
thiophene)-2, 5-dihydropyrrolo[3, 4-c]
pyrrole-1, 4-dione derivative and
phenothiazine borate. By means of a reprecipitation method, the
reagent can acquire a nano material with absorption
wavelength in a near-
infrared area, the nano material has high
singlet oxygen yield, good
photothermal conversion efficiency, excellent water dispersibility and
tumor tissue targeting properties, can be applied to tumor
cell and
living body treatment, can effectively inhibit
tumor cell migration while effectively killing
tumor cells, thereby achieving the photothermal and photodynamic synergistic
treatment effect. Therefore, the reagent can have enormous application prospects in
tumor therapy.