8results about "Electrophoretic profiling" patented technology

Devices and methods for characterizing an analyte mixture are provided. Some methods described herein include performing an enrichment step on a device prior to discharging an enriched analyte fraction from the device for subsequent analysis. The invention also comprises a device for carrying out the enrichment steps.

Some embodiments described herein relate to systems and methods operable to combine immunoassays and total protein techniques in a single sample run. Some embodiments described herein allow multiple sequential immunoassays to be performed in the same microfluidic device. Some embodiments described herein relate to stripping reagents operable to remove primary antibodies associated with immunoassays. Such stripping reagents allow additional immunoassays and / or total protein assays to be performed on the same sample.

Methods of determining the identity of a protein of interest within a sample comprising running the sample through a porous media within a nanochannel, determining a dynamic trajectory of the protein of interest as it moves through the porous media, measuring abundance of at least one amino acid in the protein and determining the protein's identity based on the abundance of the amino acid and at least one parameter calculated from the dynamic trajectory; are provided. Methods of detecting a protein in a stream of images taken of a porous media in a nanochannel are also provided.

Methods of determining the identity of a protein of interest within a sample comprising running the sample through a porous media within a nanochannel, determining a dynamic trajectory of the protein of interest as it moves through the porous media, measuring abundance of at least one amino acid in the protein and determining the protein's identity based on the abundance of the amino acid and at least one parameter calculated from the dynamic trajectory; are provided. Methods of detecting a protein in a stream of images taken of a porous media in a nanochannel are also provided.

Some embodiments described herein relate to systems and methods operable to combine immunoassay and Total Protein techniques in a single sample run. Some embodiments described herein allow for multiple sequential immunoassays to be performed in the same microfluidic device. Some embodiments described herein relate to stripping reagents operable to remove primary antibodies associated with immunoassays. Such stripping reagents can allow for additional immunoassays and / or Total Protein assays to be performed on the same sample.

Certain embodiments described herein relate to systems and methods operable to combine immunoassays and total protein techniques in a single sample run. Certain embodiments described herein allow for the performance of multiple sequential immunoassays in the same microfluidic device. Certain embodiments described herein relate to stripping reagents operable to remove primary antibodies associated with an immunoassay. Such stripping reagents can allow for additional immunoassays and / or total protein assays to be performed on the same sample.

To provide devices and methods for characterizing analyte mixtures.SOLUTION: Some methods described herein comprise performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.SELECTED DRAWING: Figure 1