The invention discloses a system and a process for sludge in situ decrement enhanced by utilizing metazoan and application of the process. The system comprises an anaerobic zone, an anoxic zone, an oxic zone, a metazoan growing zone and a secondary sedimentation zone. A biochemical system can perform in situ decrement through arranging the metazoan growing zone in the sewage treatment process; and cultivated and domesticated metazoan is continuously added in the metazoan growing zone to enhance organism predation, thereby achieving the purpose of sludge in situ decrement and realizing sludge decrement effect of 50-80% of activated sludge. The process of activated sludge in situ decrement with an efficient biological method is suitable for any activated sludge methods and deformation technologies thereof, such as A<2>/O (anaerobic-anoxic/oxic), A/O (anoxic/oxic), SBR (sequencing batch reactor), MSBR (modified sequencing batch reactor), CASS (cyclic activated sludge System), oxidation ditch, MBR (membrane bio-reactor) and the like, can also be used for a biological treatment technology having a biological carrier, can be used for sludge decrement of a newly-built sewage treatment engineering and can also be used for transformation of a built engineering with extremely low transformation cost.