The invention relates to the technical field of medical big data, in particular to a disease prediction, biological target and drug research and development integrated big health platform based on gene big data. The integrated big health platform comprises an application support unit, a data processing unit, a function application unit and a service management unit, the application support unit is used for providing application terminal equipment, an application platform and an intelligent technology which support operation of the platform system; the data processing unit is used for performing screening, clustering, analysis and other processing on the gene big data in the database to obtain a result as a basis for predicting diseases; the function application unit is used for extending various functional applications according to a data processing result; and the service management unit is used for providing intelligent health management service for the user on the basis of the data processing result and the function application. According to the design, information islands can be eliminated, mass medical data can be obtained, individualized medicine can be developed, biological and public health monitoring can be achieved, and individualized health monitoring service can be provided.