The present invention discloses a composite fertilizer with a pomegranate insect disinfestation effect. The composite fertilizer comprises composting chicken manure, plant ash, borax, ferrous sulfate, river mud with the age of more than five years, cottonseed cake, potassium ore powder, vinegar lees, citric acid residue, ammonium phosphate, urea, peanut shell powder, a water retention agent, anchusa italic, rumex madaio, areca catechu, quisqualis indica, garlic and agrimonia pilosa. With the composite fertilizer using the formula of the present invention, the sufficient nutrients can be provided for pomegranate growth, the soil salinization can be avoided, the soil fertility can be maintained for a long time, the number of the pomegranate plant disease and insect pests can be reduced, the number of the pesticide use is reduced, the cost is reduced, and the fruited pomegranate fruit is green and healthy.