The invention provides a self tightening flow passage sealing structure. The self tightening flow passage sealing structure is arranged inside equipment or a pipeline and comprises a shell, a sleeve and a baffle; the shell is fixed on a support platform through a cover plate and is provided with a cavity, an inlet and an outlet, and both the inlet and the outlet communicate with the cavity; the sleeve is hollow tubular and is fixed on the cavity, a gap is formed between the sleeve and the cavity through a flanging provided by the outer wall, and the outer wall of the sleeve is provided with aboss and a guide hole; the baffle is annular, sleeves the sleeve, and is arranged in the gap, the outer ring is fixed on the inner wall of the cavity, and the inner ring is connected with the boss ina gap; and the thermal expansion coefficient of the sleeve is different from that of the shell and/or the baffle, so that the sleeve, the shell and/or the baffle are heated to expand to generate the thermal expansion difference when heated liquid flows in the sleeve, the shell and/or the baffle, and the sealing effect is achieved by the relative extrusion of the boss and the baffle. The self tightening flow passage sealing structure uses the thermal expansion characteristic of materials to seal, so that the structure is simpler, the reliability is higher, the service life is longer, and the manufacturing difficulty and the manufacturing cost are reduced without regular maintenance.