The invention provides a building structure with good ventilation performance and a using method thereof, and belongs to the technical field of building structures. Comprising a wall body, a through hole is formed in the wall body, and a window frame is installed in the through hole. The ventilation unit, the cleaning unit and the clamping unit are arranged, the ventilation unit ventilates the interior of the building structure, meanwhile, the ventilation unit drives the glass window to be opened, air in the building is led out, the purpose of air exchange between the interior and the exterior of the building is achieved, and the ventilation efficiency is further improved; the inner side and the outer side of the glass window are automatically cleaned through the cleaning unit, a manual cleaning mode is replaced, use is convenient, meanwhile, in the glass window opening process, through cooperation of the clamping unit, the glass window drives the screen window to be automatically opened, a manual opening mode is replaced, in the ventilation process, through protection of the screen window, outside mosquitoes are prevented from entering, and the ventilation effect is good. And the comfort during ventilation is further improved.