The invention relates to the fields of soft robots, pneumatic control and bionics, in particular to a six-degree-of-freedom compliant joint driven by pneumatic muscles. The compliant joint includes the pneumatic muscles, displacement sensors, universal joint couplings, a static platform, a lower-end sleeve, deep groove ball bearings, a supporting pressure spring and a movable platform. Three setsof reaming holes are formed in the movable platform, the included angle of every two sets of reaming holes is 120 degrees, which conforms to the Stewart feature distribution, each reaming hole set comprises two identical reaming holes, and the distance between any reaming hole and the center point of the movable platform serves as a radius R1; the static platform is identical to the movable platform, each reaming hole set comprises two identical reaming holes, and the distance between any reaming hole and the center point of the static platform serves as a radius R2; R2 is greater than R1. Thesix-degree-of-freedom compliant joint is in parallel connection with a bionic joint and has spatial six-degree-of-freedom movement and large posture movement space, and the movement mechanism range of the compliant joint is similar to that of the neck joint of the human body; meanwhile, the motion compliance of the mechanism is improved, and the adjustable posture range of the mechanism is widened.