39 results about "Cyclohexane carboxylate" patented technology

The invention discloses a method for preparing calcium3-oxido-5-oxo-4-propionyl cyclohex-3-enecarboxylate. According to the method for preparing calcium3-oxido-5-oxo-4-propionyl cyclohex-3-enecarboxylate, diethyl maleate and acetone are used as raw materials, Michael addition is conducted under the catalytic action of diethylamine, Claisen condensation is conducted under the action of organic alkali, after acidification is conducted through an organic acid or a mineral acid of a non-aqueous solvent or phenols having acidity, 5-Carboxycyclohexane-1,3-dione is obtained, acylation, rearrangement, hydrolysis and a salt forming reaction are conducted under the action of acid-binding agent, and then the target product, prohexadione-calcium, can be obtained. According to the method for preparing calcium3-oxido-5-oxo-4-propionyl cyclohex-3-enecarboxylate, six steps of reactions are completed in a one-pot mode, and the problem that waste water, waste residues and the like generated in the reaction process of each step pollute the environment is solved. The preparation method of calcium3-oxido-5-oxo-4-propionyl cyclohex-3-enecarboxylate has the advantages that operation is easy, column chromatography chromatograph is not needed, the preparation cost is low, environmental friendliness is achieved, and the preparation method is suitable for industrial production.

The invention discloses a preparation method for the high-purity edoxaban intermediate (1S,3R,4R)-3-tertbutyloxycarbonylamino-4-hydroxy-naphthenic acid. The preparation method comprises the followingsteps: with 3-amino-4-hydroxy-cyclohexane carboxylate as shown in a formula (IV) which is described in the invention as a raw material, subjecting the raw material to protection by an amino protectivegroup so as to obtain 3-tertbutyloxycarbonylamino-4-hydroxy-cyclohexane carboxylate as shown in a formula (V) which is described in the invention; and carrying out enzyme hydrolysis and splitting soas to obtain optically pure (1S,3R,4R)-3-tertbutyloxycarbonylamino-4-hydroxy-naphthenic acid as shown in a formula (VI) which is described in the invention. The preparation method provided by the invention has the advantages of simple operation, environmental protection, high selectivity, low cost and the like, can realize large-scale industrial production, and is convenient for industrial promotion and application.

There is provided a heat shrinkable film comprising a polyester based copolymer capable of having an excellent shrinkage rate and being heat shrunk at a low temperature. The heat shrinkable film according to an exemplary embodiment of the present invention includes a polyester based copolymer, wherein the polyester based copolymer includes: a dicarboxylic acid-derived residue including a residue derived from an aromatic dicarboxylic acid; and a diol-derived residue including a residue derived from 4-(hydroxymethyl)cyclohexylmethyl 4′-(hydroxymethyl)cyclohexane carboxylate represented by the following Chemical Formula 1 and a residue derived from 4,4-(oxybis(methylene)bis) cyclohexane methanol represented by the following Chemical Formula 2.

A polyester based copolymer resin which can be used a heat shrinkable film is disclosed. The polyester based copolymer resin includes a dicarboxylic acid-derived residue including a residue derived from an aromatic dicarboxylic acid, and a diol-derived residue including a residue derived from 4-(hydroxymethyl)cyclohexylmethyl 4′-(hydroxymethyl)cyclohexane carboxylate and a residue derived from 4,4-(oxybis(methylene)bis) cyclohexane methanol. The heat shrinkable film including polyester based copolymer resin has a shrinkage initiation temperature of 60° C. or less, the maximum heat shrinkage rate at 60° C. of 4% or more, and the maximum heat shrinkage rate at 90° C. of 80% or more.

A heat shrinkable film comprising a polyester based copolymer is provided. The heat shrinkable film according to an exemplary embodiment of the present invention includes a polyester based copolymer, wherein the polyester based copolymer includes: a dicarboxylic acid-derived residue including a residue derived from an aromatic dicarboxylic acid; and a diol-derived residue including a residue derived from 4-(hydroxymethyl)cyclohexylmethyl 4′-(hydroxymethyl)cyclohexane carboxylate represented by the following Chemical Formula 1 and a residue derived from 4,4-(oxybis(methylene)bis) cyclohexane methanol represented by the following Chemical Formula 2;

The present invention relates to a cyclohexanecarboxylic acid ester preparation method, wherein the compound is obtained by carrying out selective hydrogenation on a phthalic acid derivative, and the used hydrogenation catalyst is a Ni, Co, Mn and Al2O3-SiO2 composite nano-tube array film hydrogenation catalyst, wherein the catalyst has high activity and high selectivity in the cyclohexanecarboxylic acid ester preparation reaction through the selective hydrogenation of the phthalic acid derivative, and the hydrogenation product is a class of the wide-application plasticizers.

The invention discloses a preparation method of prohexadione calcium. Dialkyl maleate which is higher alkyl maleate having higher lipid solubility than dimethyl maleate and diethyl maleate is taken as the raw material,subjected to Michael addition under catalysis of diethylamine, then subjected to Claisencondensation under the action of organic base, and is acidized by anhydrous organic acid, anhydrous mineral acid, anhydrous phenols or inorganic diluted acid to obtain 3,5-dioxocyclohexanecarboxylate ester; then acylation under the action of an acid-binding agent, rearrangement, hydrolysis and a salt-forming reaction are performed to obtain the target productprohexadione calcium. The preparation method of prohexadione calcium has the advantages of simple operation, no need of column chromatographic separation, low preparation cost, environmental protection and suitability to industrialproduction.

There is provided a composition for forming a heat shrinkable film capable of providing a heat shrinkable film capable of having an excellent shrinkage rate and being heat-shrunk at a low temperature. The composition for forming a heat shrinkable film includes a polyethylene terephthalate (PET) resin having an inherent viscosity of 0.50 to 1.2 dl / g, and a polyester based copolymer including a dicarboxylic acid-derived residue including a residue derived from an aromatic dicarboxylic acid and a diol-derived residue including a residue derived from 4-(hydroxymethyl)cyclohexylmethyl 4′-(hydroxymethyl)cyclohexane carboxylate represented by the following Chemical Formula 1 and a residue derived from 4,4-(oxybis(methylene)bis) cyclohexane methanol represented by the following Chemical Formula 2.

The invention discloses a preparation method of trinexapac-ethyl and an intermediate thereof. The method comprises the following steps: under the action of an alkali, reacting acetoacetic ester (I) with diethyl maleate to obtain an intermediate (II), continuing reaction under the action of an acid to obtain diethyl 2-acetonyl-1,4-succinate; cyclizing the diethyl 2-acetonyl-1,4-succinate in the presence of an alkali, and acidifying to obtain ethyl 3,5-cyclohexyldione-formate; esterifying the ethyl 3,5-cyclohexyldione-formate and cyclopropyl formyl chloride in the presence of an acid-binding agent to obtain ethyl 4-cyclopropylformacyl-3,5-dione cyclohexane-carboxylate; and carrying out reaction on the end product under the actions of an organic alkali and a catalyst to obtain the trinexapac-ethyl. The technique has the advantages of favorable reaction selectivity, high yield and fewer byproducts, and is beneficial to obtaining the high-quality trinexapac-ethyl product. The method does not have high requirements for equipment, and avoids high-temperature high-pressure reaction. The method has the advantages of simple technique and mild reaction conditions, and is suitable for industrialization.

The invention discloses a preparation method of a high-purity edoxaban intermediate (1S, 3R, 4R)-3-tert-butoxycarbonylamino-4-hydroxy-cyclohexanecarboxylic acid. With the 3-amino-4-hydroxyl-cyclohexane carboxylate shown in formula (Ⅳ) as raw material, obtain 3-tert-butoxycarbonylamino-4-hydroxyl-ring as shown in formula (Ⅴ) after the protection of amino protecting group Hexane carboxylate, and enzymatic hydrolysis and resolution to obtain optically pure (1S, 3R, 4R)-3-tert-butoxycarbonylamino-4-hydroxy-cyclohexanecarboxylic acid represented by formula (VI). The method of the invention has the advantages of simple operation, environmental protection, high selectivity, low cost, etc., can realize large-scale industrial production, and is convenient for industrial popularization and application.

The invention discloses a catalyst for production of cyclohexylcarboxylate by phenylcarboxylate hydrogenation and its preparation method and use. The catalyst comprises 5 to 50wt% of an active component Ni, 0.1 to 25wt% of at least one auxiliary agent and the balance a carrier. The catalyst has the advantages of low price and very high activity and selectivity.

The invention discloses a cationic silk fibroin / gene complex, a preparation method and an application thereof, and belongs to the technical field of biomedical polymer materials. The present invention constructs a novel biodegradable cationic silk fibroin gene transfer carrier with cell targeting and cell nucleus localization functions, which is mediated by water-soluble 2-iminothiolane hydrochloride protamine sulfate Produced by coupling silk fibroin activated with sulfosuccinimidyl-4-[N-maleimidomethyl]-cyclohexane-1-carboxylate and forms cations with genetic material by electrostatic interaction Fibroin / gene complex has good biocompatibility and degradability, controllable surface charge density, ability to effectively compress and protect DNA, high transfection efficiency, unique cell targeting and nuclear localization functions.

Provided is an adhesive composition for multilayer semiconductors. The adhesive composition gives, when applied and dried by heating, an adhesive layer that has approximately no adhesiveness at a temperature lower than 50° C., but, when heated at such a temperature as to less cause damage to semiconductor chips, offers adhesiveness and is rapidly cured thereafter. This adhesive composition for multilayer semiconductors includes a polymerizable compound (A), at least one of a cationic-polymerization initiator (B1) and an anionic-polymerization initiator (B2), and a solvent (C). The polymerizable compound (A) contains 80% by weight or more of an epoxide having a softening point or melting point of 50° C. or higher. The cationic-polymerization initiator (B1) gives a composition having a thermal curing time of 3.5 minutes or longer at 130° C., where the composition contains 1 part by weight of the cationic-polymerization initiator (B1) and 100 parts by weight of 3,4-epoxycyclohexylmethyl (3,4-epoxy)cyclohexanecarboxylate. The anionic-polymerization initiator (B2) gives a composition having a thermal curing time of 3.5 minutes or longer at 130° C., where the composition contains 1 part by weight of the anionic-polymerization initiator (B2) and 100 parts by weight of bisphenol-A diglycidyl ether.

The invention discloses a UV woodware paint for carbonized material, and a manufacturing method thereof. The UV woodware paint is prepared by taking epoxy acrylic resin, polyurethane acrylic resin, tetraethylammonium bromide, cobalt cyclohexane carboxylate, chitosan powder, adequate amount of absolute ethyl alcohol, titanium dioxide powder, fatty alcohol-polyoxyethylene ether, GST modified epoxy carbon-sticking glue, functional components extracted from cornu gorais, closed isocyanate, and defoaming agent as raw material and taking deionized water as the medium to sufficiently react at 70-85 DEG C, whereien the preparation process of the function components comprises infiltrating, dicing, braising, purifying and concentrating. The UV woodware paint disclosed by the invention has the technical effects of being dedicated to the carbonized wood surface, cured by ultraviolet, incapable of damaging the wood, high in adhesive force, high in wear resistance, high in permeation, and self-hydrophobic.