39 results about "Cyclohexenyl-G" patented technology

One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage.

The present invention relates to the use of modified nucleotides and single or double stranded oligonucleotides having at least one of said modified nucleotides for performing RNA interference. The modified nucleotides are selected from 6-membered ring containing nucleotides such as hexitol, altritol, O-substituted or O-alkylated altritol, cyclohexenyl, ribo-cyclohexenyl and O-substituted or O-alkylated ribo-cyclohexenyl nucleotides. The present invention also relates to novel modified nucleosides or nucleotides and to the use of the novel modified nucleosides and nucleotides in single or double stranded oligonucleotides for RNA interference, antisense therapy or other applications.

The invention relates to a method for preparing cyclohexenyl cyclohexanone which is the intermediate of o-phenyl phenol, particularly to a method for preparing the cyclohexenyl cyclohexanone with high conversion rate and high selectivity by taking cyclohexanone as raw material and taking solid oxide as catalyst.

The present invention relates to the technical field of liquid crystals, particularly to a liquid crystal composition containing a cyclohexenyl liquid crystal compound, wherein the liquid crystal composition contains one or a plurality of compounds represented by a general formula I and one or a plurality of compounds represented by a general formula II, the compound represented by the general formula I is a compound with a cyclohexene structure, and has high negative dielectric anisotropy, and the compound represented by the general formula II is a bicyclic structure compound, has low rotational viscosity, and can effectively reduce the rotational viscosity of the liquid crystal composition and improve the response time of the liquid crystal display device. According to the present invention, the liquid crystal composition has low rotational viscosity, can be used for quick-response liquid crystal display in various display modes, and can significantly improve the display effects of liquid crystal display devices in VA, MVA, PVA, PSVA and other VA mode display devices or IPS or FFS mode display devices. The formulas I and II are defined in the specification.

The invention relates to a negative dielectric anisotropy liquid crystal composition and applications thereof. The composition includes at least one compound represented by a general formula I and at least one compound represented by a general formula II. The compounds represented by the general formula I are bis(cyclohexenyl) compounds and have extremely low rotational viscosity and excellent intersolubility. The compounds represented by the general formula II are compounds containing cyclohexenyl and a 2,3-difluoro type structure, have high negative dielectric anisotropy and low rotational viscosity, and can effectively improve negative dielectric anisotropy of the composition. The composition has low rotational viscosity and can be used for fast-response liquid crystal display apparatuses of a plurality of modes.

The invention provides a method for preparing 2-aryl malonamide and application thereof. According to the method, 2-(cyclohexadienylidene)malononitrile is used as a raw material and undergoes an aromatization-hydrolysis reaction under the action of an oxidizing agent and water so as to obtain 2-arylmalonamide in one step. Compared with the prior art, the method for preparing 2-arylmalonamide provided by the invention has the following remarkable features and advantages: (1) completely different synthesis strategies are adopted; (2) the raw material is simple and easily available; and (3) yieldis high, the use of expensive metal catalysts is avoided, cost is low, and the method is suitable for industrial production.

A compound represented by Formula (1) and a polymer obtained using the compound: wherein R1 is phenyl which may have substituents, Q1 is hydrogen, halogen, alkyl having 1 to 10 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl or phenyl in which optional hydrogen may be replaced by halogen or alkyl having 1 to 5 carbon atoms, Q2 is a group represented by Formula (2): wherein the code < represents a bonding point with silicon, l, m, n and p are independently 0, 1, 2 or 3, and A1 to A4, Z0 to Z4 and Y1 are defined in the specification.

The present invention relates to a triazole compound. Said invention provides its general formula. Its preparation method includes the following steps: using 5-triazo-1,2,4 triazol-3-acyl methyl ester and propiolic alcohol ester acetate, p-amyl phenylacetylene, syclohexanol alkyne, cyclohexene alkyne or methoxyphenyl acetylene, and making them be reacted in the tetrahydrofuran or mixed solvent of tetrahydrofuran and water at 10-100 deg.C under the action of Cu(I) catalyst so as to obtain the required triazole compound. Said triazole compound has the activity for directly inhibiting plant virus, in particular inhibiting tobacco mosaic virus.

The invention discloses a liquid crystal composition and a display element comprising the liquid crystal composition. The liquid crystal composition contains one or more compounds shown in the generalformula I, the general formula II and the general formula III. The liquid crystal composition has excellent properties, and the optical anisotropy is within the range of 0.080-0.150; moreover, the composition has low rotary viscosity, short response time and good chemical, optical and thermal stability, thereby being quite suitable for producing the liquid crystal display element and particularlysuitable for an active matrix display element, such as an active matrix displayer adopting a VA or FFS or IPS mode.

The invention relates to an aqueous dispersion which comprises a) a flameproofing agent of general formula (I), wherein R1represents hydrogen, C1-4 alkyl, -CH2CI, -CH2Br, -CH2O-C1-4 alkyl or phenyl, R2 represents hydrogen, C1-4 alkyl, -CH2CI, -CH2Br or -CH2O-C1-4 alkyl, or R1 and R2, together with the ring carbon atoms bound to them, represent cyclohexylidene, cyclohexenylidene or 3,4-dibromocyclohexylidene, R3 and R5 independently represent hydrogen or C1-4 alkyl, R4 represents hydrogen or methyl, and X represents oxygen or sulfur, and b) an acrylate copolymer which substantially consists of 50 to 80 mole % of monoalkenyl aromatics and 20 to 50 mole % of acrylates. The inventive aqueous dispersion has an average molar mass Mv between 1000 and 50.000 g / mol.

The invention discloses a series of PHOLED (phosphorescent organic light-emitting diode) materials. The general structural formula of the PHOLED materials is represented as a formula I-1 or a formula I-2. A series of iridium complex electrophosphorescent light-emitting materials with cyclohexyl groups and cyclohexene groups are provided on the basis that electrophosphorescent materials require high thermal stability, high quantum efficiency and lower doping ratio. The compounds have the characteristics of excellent film-forming properties, low probability of crystallization, high luminous efficiency and the like, raw materials are easy to obtain, preparation is simple and convenient, the total yield is high, the cost of phosphorescent materials is reduced greatly, and the PHOLED materials have important application values.

The present invention provides novel tricyclic pyridyl carboxamides as well as methods and pharmaceutical compositions utilizing them compounds for the treatment and / or prevention and / or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and / or suppression of preterm labor, suppression of labor at term prior to caesarean delivery, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

The invention discloses a method for preparing bis((3,4-epoxycyclohexyl)methyl)adipate with a microchannel reactor, comprising the following steps: using 3-cyclohexene-1-methanol and adipic di Acyl chloride is raw material, carries out esterification in the first microreactor and makes intermediate bis((3-cyclohexenyl) methyl) adipate; Take peracetic acid as oxygenant, in the second microreactor The carbon-carbon double bond of cyclohexenyl on the intermediate bis((3-cyclohexenyl)methyl) adipate is carried out selective epoxidation reaction to prepare bis((3,4-epoxy Cyclohexyl)methyl)adipate. The present invention adopts the in-situ method to carry out the epoxidation reaction of olefins while preparing peracetic acid, and the technological process is easy to operate; the esterification reaction temperature is low, the side reactions are few, the aftertreatment is simple, and the efficiency is high; the reaction yield is high and the product The purity is high, and the conversion rate of the intermediate product and the selectivity of the product have been significantly improved; the separation process of the product is easy to operate, and is suitable for a continuous production process.

The present invention relates to a method for synthesizing organic compounds. A process for synthesizing 4-heteroatom substituted cyclohexenyl halides, from cyclohexanone substituted by 4-heteroatom ( 1 ) starting with 1-50 equivalents of anhydrous hydrazine or hydrazine hydrate in a solvent, -20? oC to reflux reaction, after filtering or spin-drying the solvent to obtain the corresponding hydrazone, and then react with CuX2 / alkali mixture in alcohol solvent, the reaction temperature is -20? cC~40? oC, add alkaline aqueous solution and solvent after the reaction, obtain a mixed solution after liquid separation, add an organic base for reflux reaction, add 1N acid to remove the excess alkali, add saturated NaHSO3 for reaction, and remove the solvent to obtain a 4-position heteroatom Substituted cyclohexenyl halides ( 3 ). The synthesis process route of the present invention has originality, simple route, mild process conditions, simple and convenient operation, avoids the ultra-low temperature reaction and column chromatography purification involved in the literature, and is suitable for industrial scale-up production.

The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R1, R2, R3 and R4 independently represent the hydrogen atom, halo, (C2-C6) alkenyl, (C3-C7)cycloalkyl, cyclohexenyl and a radical having formula —(CH2)m—V—W.

The invention provides a method for preparing 2-aryl malonamide and application thereof. According to the method, 2-(cyclohexadienylidene)malononitrile is used as a raw material and undergoes an aromatization-hydrolysis reaction under the action of an oxidizing agent and water so as to obtain 2-arylmalonamide in one step. Compared with the prior art, the method for preparing 2-arylmalonamide provided by the invention has the following remarkable features and advantages: (1) completely different synthesis strategies are adopted; (2) the raw material is simple and easily available; and (3) yieldis high, the use of expensive metal catalysts is avoided, cost is low, and the method is suitable for industrial production.

NEO218 (3-bromo-2-oxyylidene-propionic acid 4-isopropenyl-cyclohex-1-enyl methyl ester) (see formula I) is produced from two unrelated reagents: 3-bromopyruvate (3‑BP; an alkylating agent that inhibits cancer cell metabolism) and perillyl alcohol (POH; a natural monoterpene with anticancer properties) resulting in a novel molecule. Also disclosed are methods of synthesizing NEO218, pharmaceutical compositions comprising NEO218, and methods of using NEO218 to treat cancer.

Modulation of quorum sensing in Gram-negative bacteria, particularly strains of Pseudomonas which form biofilms, by compounds including those of formula I and formula II:where:AR is optionally substituted phenyl, cycloalkyl or cycloalkenyl or heterocyclic, and R1 is optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkylthioalkyl or alkyl substituted at the omega position with optionally substituted phenyl, cyclohexyl or cyclohexenyl. In particular compounds inhibit quorum sensing and biofilm formation. Pharmaceutical compositions for treatment of bacterial infections and methods of treatment of such infections are provided.

The present disclosure describes cyclohexenyl nucleic acid analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, cyclo-hexenyl nucleic acid analogs are provided, having one or more chiral substituents, that are expected to be useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

The invention discloses a synthesis method of near-infrared two-zone fluorescent dye FD-1080, which comprises the following steps: by taking benzo [cd] indol-2 (1H)-ketone as a starting material, firstly introducing tert-butylcarbonyl (Boc) on amido to protect the amido, then introducing methyl by utilizing a Grignard reagent in a ring opening manner, and then completing Boc protecting group removal and intramolecular cyclization reaction in one step by using an ethyl acetate solution of hydrogen chloride to obtain the near-infrared two-zone fluorescent dye FD-1080. The synthesis method comprises the following steps of: firstly, introducing sulfonic acid through nucleophilic substitution, and finally reacting with N-[(3-(anilinomethylene)-2-chloro-1-cyclohexene-1-yl) methylene] aniline hydrochloride to synthesize FD-1080, the whole synthesis process is safe and pollution-free, a product with higher purity can be synthesized without column chromatography purification, and the synthesis method can be used for amplified production of FD-1080.

The invention relates to a negative dielectric anisotropy liquid crystal composition and applications thereof. The composition includes at least one compound represented by a general formula I and at least one compound represented by a general formula II. The compounds represented by the general formula I are bis(cyclohexenyl) compounds and have extremely low rotational viscosity and excellent intersolubility. The compounds represented by the general formula II are compounds containing cyclohexenyl and a 2,3-difluoro type structure, have high negative dielectric anisotropy and low rotational viscosity, and can effectively improve negative dielectric anisotropy of the composition. The composition has low rotational viscosity and can be used for fast-response liquid crystal display apparatuses of a plurality of modes.

The invention discloses a series of phosphorescent OLED materials. The general structural formula of the phosphorescent OLED material is shown in formula I-1 or formula I-2. The present invention provides a series of iridium complex electrophosphorescent materials with cyclohexyl and cyclohexene groups based on the need for high thermal stability, high quantum efficiency and low doping ratio of electrophosphorescent materials . This type of compound has the characteristics of excellent film-forming property, not easy to crystallize, high luminous efficiency, easy to obtain raw materials, simple preparation, high overall yield, greatly reduced cost of phosphorescent materials, and has important application value.

The invention provides a synthesis method of a ferrocene derivative luminescent material. The synthesis method is characterized by heating cyclohexenyl ferrocene and a precursor compound in anhydrous toluene to react. According to the reaction, a benzyne intermediate with extremely high activity is used as an induction reaction, so that the reaction of the ferrocene derivative and alkyne under the condition of no additional metal catalyst is realized, the inherent property that conventional ferrocene is not subjected to hydrogenation and is not subjected to Diels-Alder reaction as a diene is also overcome, a huge breakthrough is brought to synthesis of the ferrocene derivative, and a brand new way is provided for developing the ferrocene derivative luminescent material.

The present invention relates to hydrogenation processes including: contacting a first composition with hydrogen under hydrogenation conditions, in the presence of an eggshell hydrogenation catalyst, wherein the first composition has: (i) greater than about 50 wt % of cyclohexylbenzene, the wt % based upon the total weight of the first composition; and (ii) greater than about 0.3 wt % of cyclohexenylbenzene, the wt % based upon the total weight of the first composition; and thereby obtaining a second composition having less cyclohexenylbenzene than the first composition. Other hydrogenation processes are also described.