35 results about "False Aneurysms" patented technology

A method for increasing the rate of thrombus formation and / or proliferative cell growth of a selected region (21) of cellular tissue (22) including the step of endovascularly irradiating the selected region (21) with radiation, having a dose range of endovascular radiation of about 1 Gy to about 600 Gy at a low dose rate of about 1 cGy / hr to about 320 cGy / hr, to increase thrombus formation and / or cell proliferation of the affected selected region (21). Preferably, the delivery means includes a deformable endovascular prosthesis (25) adapted for secured positioning adjacent to the selected region (21) of cellular tissue (22), and a radioactive source. This source cooperates with the deformable endovascular device (25) in a manner endovascularly irradiating the selected region with radiation, having the above-indicated dose range and low dose rate of endovascular radiation to increase thrombus formation and / or cell proliferation of the affected selected region (21).

Implantable therapeutic devices and methods for endovascular placement of devices at a target site, such an opening at a neck of an aneurysm, are disclosed. Selected embodiments of the present technology have closures (102) that at least partially occlude the neck of an aneurysm to stabilize embolic or coagulative treatment of the aneurysm. In one embodiment, for example, an aneurysm closure device comprises a closure structure (102) and a supplemental stabilizer (103). The closure structure can have a curved portion configured to extend along a first vessel, such as a side branch of a bifurcated vessel that extends along a lateral axis (T). The supplemental stabilizer extends from the closure structure along a longitudinal axis (L) transverse to the lateral axis of the first vessel. The supplemental stabilizer is configured to exert an outward force against a second vessel, such as a parent vessel, that extends transversely to the first vessel.

A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.

The present invention includes a method for treating an aneurysm. The method includes providing a biocompatible polymeric string or hollow tube and transporting the string or hollow tube to the aneurysm. The aneurysm is filled with the string. The string is cut when the aneurysm is substantially filled.

Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and / or the tissue surface of the aneurysm.

An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including a structure having a fixed porosity and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel. The device further includes a frangible material supported by the structure which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel.

Disclosed is an antithrombotic neurovascular device useful for the treatment of brain aneurysms and / or acute ischemic stroke. The device comprises a mechanical structure, which may be a stent, stent-like structure, or flow diverter, and a drug-eluting coating. This device is designed for local delivery of antiplatelet medication to the site of device implantation in order to improve outcomes for the population of brain aneurysm and / or acute ischemic stroke patients currently being treated with stents, and for use with patients presenting with ruptured aneurysms, in whom systemic dual antiplatelet therapy is contraindicated. The coating comprises an antiplatelet drug, preferably, a GPIIb / IIIa receptor inhibitor, more preferably, abcixmab, and optionally comprises a polymeric binder that functions as a drug modulating polymer. Also disclosed are methods for producing the antithrombotic neurovascular device, and using the device for the treatment of brain aneurysms and / or acute ischemic stroke.

The embodiment of the invention discloses an aneurysm rupture risk assessment method and system, and the method comprises the steps: obtaining to-be-processed data which comprises first data and / or second data; inputting the to-be-processed data into an aneurysm risk assessment model to obtain an aneurysm risk assessment result of the to-be-processed data, the aneurysm risk assessment model beinga model obtained in advance based on a neural network method, and the aneurysm rupture risk assessment result comprising an aneurysm rupture probability and / or an important feature factor; and outputting the aneurysm risk assessment result of the to-be-processed data. According to the aneurysm rupture risk assessment method and system provided by the embodiment of the invention, the participationof human factors can be eliminated or reduced, the time consumption is shortened, the aneurysm rupture risk assessment can be simply and rapidly carried out, and objective support is provided for theaneurysm rupture risk assessment.

The invention belongs to the technical field of image processing, particularly relates to a method for detecting an interventional instrument in an intravascular aneurysm repair operation, and aims tosolve the problem that the interventional instrument in an X-ray transmission image in the intravascular aneurysm repair operation cannot be accurately segmented and tracked in real time. The methodcomprises the following steps: taking an X-ray transmission image of a region containing an interventional instrument as a to-be-detected image; generating a binary segmentation mask of the interventional instrument through the trained fast attention network; and covering the binary segmentation mask on the to-be-detected image to obtain an image of the interventional instrument. According to themethod, the problem that the number of foreground pixels and the number of background pixels are extremely unbalanced and the problem of wrong classification of images are solved, the speed and accuracy of X-ray transmission image recognition on segmentation of surgical interventional instruments and image tracking in the prior art are improved, and the requirement for assisting doctors in endovascular aneurysm repair surgery in real time can be met.

The invention discloses a magnetic device applied to the anastomosis of large and medium blood vessels. The magnetic device finishes the anastomosis of the blood vessels with different vessels diameters by utilizing two permanent magnet anastomosis rings comprising permanent magnets and corresponding to the vessel diameters of the large and medium blood vessels to be anastomosed so as to avoid the shortcomings of narrow lumens, false aneurysms, anastomotic stoma seepage, low anastomosis speed and great complication number caused by manual suturing anastomosis, avoids the shortcomings of narrow anastomotic stomas, blood seepage, hematorrhea caused by the slippage of ligatures, local tissue granuloma and pseudo artery formation because the two permanent magnet anastomosis rings are opposite to each other and smooth to realize the neat suture of intimae of the blood vessels, ensures the anastomosis speed which is increased by proximately over 10 times compared with manual anastomosis, and avoids blow flows of tissues and organs being blocked for long to cause the congestion and edema of the tissues and the organs to further cause anastomosis errhysis.

A three-dimensional rotational angiography (3DRA) system, in which a finite element method (FEM) package is incorporated which can read in suface meshes (20b) of a reconstructed 3DRA image of an aneurysm to generate FEM meshes (20a) which are closely approximated to the observed aneurysm (20b) in an iterative process by changing the material properties of the aneurysm used in generating the simulated representations (20a) thereof. Thus, the material properties of the closely approximated simulated representation (20a) can be used in subsequent analysis of the physical properties of the aneurysm under consideration.

The self-expandable aneurysm filling device (102, 202), system and method provide for placement of the stent into an aneurysm (112) to at least partially fill and stabilize the aneurysm. The self -expandable aneurysm filling device (102) has a compressed undeployed configuration and an expanded three-dimensional deployed configuration, and a severable deployment junction (104, 204) releasably connects the self-expandable aneurysm filling device to a pusher wire (106, 206). The severable deployment junction can be mechanically, electrolytically, or thermally severed to separate the self-expandable aneurysm filling device from the pusher wire.

A novel modification method for commercially available tubular stent is invented. The modified stents are sandwiched between a composite membrane. The polymeric sandwich (composite membrane) is durable, which undergoing several crimping and expansion circles without broken nor pinhole. The modified stents are very useful to replace the stent-graft in the procedure of aneurysm rupture prevention. The outside layer polymer has mechanical advantages such as high degree of elasticity, excellent durability and having been approved for some clinic application. The inside polymeric layer is covalently bonded to the outside polymeric layer and at the same time is cross-linking with itself. Not only this layer of polymer is biocompatible, but also it requires limited smooth muscle cells' proliferation. In some cases, the inside polymeric layer can be used as a platform of control drug release device. The modification method could be used to produce both large stent applicable in large vessels(greater or equal to 3 mm diameter) and small stent applicable in small vessels (less than 3.0 mm diameter and can be crimped on a 1.5 mm angioplasty balloon catheter), and to produce customer length tubular stent.

Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms are disclosed. The systems include an insertable medical device and an in-situ forming foam that is formed from a polymer that reacts in an aqueous environment. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and / or the tissue surface of the aneurysm.

The invention discloses a spring ring. The spring ring comprises a spring ring body and a fiber bundle fixedly connected to the spring ring body. The spring ring has the following beneficial effects: according to the structure design of the provided spring ring, the applied friction force in a conveying pipe is lower while the spring ring is released; and the pushing force is more easily and better transmitted along the axial direction of the spring ring, and the stacking situation of the spring ring cannot be produced, so the operation difficulty of an operator is reduced, and the aneurysms rupture risk is reduced.

According to the intracranial aneurysm recognition and detection method, device and system and the computer readable storage medium, the intracranial aneurysm recognition and detection method comprises the steps of receiving and labeling original intracranial CTA images sequentially, and obtaining labeled image data; performing boundary pixel points of the aneurysm in the three-dimensional space through the marked image data, distinguishing a positive sample image block and a negative sample image block of the image data according to the boundary pixel points, wherein the positive sample image block is the area where the aneurysm is located, and the negative sample image block is the area where the non-aneurysm is located; and detecting the intracranial aneurysm in the positive and negative sample image blocks by using a deep learning model, and outputting a detection result. According to the invention, positive and negative sample image blocks are processed at the same time by using algorithms of an encoder and a decoder in a deep learning model, so that the small aneurysm detection rate is increased; a long-range jump connection algorithm introduced by a deep learning model is taken as a main part, and a short-range jump connection algorithm introduced by the long-range jump connection algorithm is taken as an auxiliary part, so that the problem of poor continuity between different layers is solved.

The invention provides an intracranial aneurysm risk prediction method and device based on artificial intelligence. The method comprises the steps of obtaining a to-be-predicted medical image, wherein the to-be-predicted medical image at least comprises graphic information of aneurysm; segmenting the to-be-predicted medical image based on a preset feature segmentation model to obtain an aneurysm three-dimensional image, wherein the aneurysm three-dimensional image comprises a pattern of the aneurysm; measuring the aneurysm pattern to obtain characteristic data of the aneurysm; inputting the characteristic data of the aneurysm and preset structured characteristic data into a preset rupture risk prediction model for prediction to obtain rupture risk data; and generating a medical diagnosis report based on the aneurysm three-dimensional image, the characteristic data of the aneurysm and the rupture risk data. According to the method, a deep learning technology is utilized in implementation, the trained learning model is used for performing aneurysm recognition and segmentation on the patient image and completing automatic measurement, the diagnosis time is greatly shortened, and the diagnosis accuracy is improved.

Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and / or repair damaged vessels.

The invention belongs to the field of medical instruments and relates to a device for being implanted in the abnormal bulging position of an arterial canal wall. The device comprises a bag capable of being implanted in the abnormal bulging position of the arterial canal wall and bulging, when the bag bulges, the bag has 3D modeling anatomy three-dimensional morphological features conforming to the implanting position, and therefore blood cannot flow into the abnormal bulging position of the arterial canal wall from an arterial canal. According to the device, the blood cannot flow into the abnormal bulging position of the arterial canal wall from the arterial canal, blood flow smoothness in the tumor-carrying arterial canal is kept, blood flow smoothness of branch blood vessels of the arterial canal is kept, thus, the device can be used for treating the diseases such as intracranial aneurysms, visceral aneurysms, false aneurysms, aortic aneurysms, artery dissection and aortic dissection, and a new way for aortic disease interventional therapy is expected to be opened up.

A shape memory spring coil is a spiral structural member made of shape memory polymer material. A manufacture method of the shape memory spring coil includes firstly manufacturing polymer threads by the process of extrusion molding; secondly, manufacturing the thread-type shape memory spring coil by a mold into a spiral shape (permanent shape); and thirdly, fixing the shape of the polymer into a straight fine-thread shape (temporary shape) by a proper method. An application method of the shape memory spring coil includes conveying the straight fine-threaded spring coil to an aneurysm cavity through a micro catheter, the fine-threaded spring coil automatically restores to the original spiral structure at human body temperature, and accordingly aneurysm is packed. The spring coil made of polymer material with biocompatibility compared with metal is small in density, low in rigidity and soft in texture, compact packing rate of the aneurysm cavity can be increased, risk of perforating aneurysm by the spring coil in operation is lowered, damage of peripheral nerves and vessels, which is caused by gravity press after embolism of the spring coil, is reduced, manufacture process is simple, and cost is low.

Liquid compositions comprising nimodipine having improved nimodipine concentrations are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the liquid compositions of the present invention are also detailed herein.

The present invention generally concerns the detection and / or treatment of aneurysm in a non-invasive manner. In particular cases, the invention concerns methods and compositions for localizing a labeled composition to the site of an aneurysm for its detection and, in further cases, treatment of the aneurysm. In specific cases, the composition targets a subendothelial component of the aneurysmal wall, such as a smooth muscle cell exposed at the luminal surface of the vessel. In further specific cases, the composition targets an integrin receptor or laminin.

The invention discloses a micro-occluder for cerebral aneurysm, which comprises a main body of the occluder, a filling liquid, a delivery tube, and a push catheter. A limit block is connected, and the liquid outlet end of the check valve is provided with a blocking body, the blocking body is made of biogel material with elastic deformation properties, and the filling liquid passes through the push conduit and the check valve Enter the bluff body. The parts of the invention have less dependence on the process size, and are especially suitable for small cerebral aneurysms. The filling fluid enters the blocking body through the push catheter and the check valve, so that the biogel material with elastic deformation performance can be used during the filling of the filling fluid. Elastic deformation occurs under the action, so as to expand and expand, and play the role of blocking cerebral aneurysms. The material of the blocking fluid is biogel material, which has bioadhesiveness and can successfully adhere to cerebral aneurysms, thereby Increase the strength of brain aneurysms and reduce the risk of brain aneurysm rupture.

The invention discloses the development and application of a MAP3K10 gene fragment clinical diagnosis detection kit for intracranial aneurysms. The detection kit includes a pair of MAP3K10 gene methylation-specific amplification primers and a methyl Methylation specific sequencing primer: wherein the upstream primer has the nucleotide sequence shown in SEQ ID NO.1, the downstream primer has the nucleotide sequence shown in SEQ ID NO.2, and the methylation specific sequencing primer is as SEQ ID NO.2 As shown in ID NO.3, the advantage is that the diagnostic kit can conveniently and quickly detect intracranial aneurysms at the molecular level, with high detection efficiency and strong pertinence. At the same time, the MAP3K10 gene methylation-targeted Drugs are expected to become a new method for auxiliary diagnosis, detection and screening of intracranial aneurysms.

The present application provides an in vitro method for determining the degradation of the extracellular matrix (ECM) in a subject, the method comprising determining in an isolated sample from the subject the level of an expression product of at least one gene selected from the group consisting of collagen type V alpha 1 chain (COL5A1), transforming growth factor beta-1 (TGFB1), integrin subunit alpha 4 (ITGA4), integrin subunit beta 1 (ITGB1), matrix metallopeptidase 2 (MMP2), matrix metallopeptidase 9 (MMP9) and bone morphogenetic protein 1 (BMP1), the at least one gene being determined optionally in combination with one or both of collagen type XI alpha 1 chain (COL11A1) and collagen type V alpha 2 chain (COL5A2), wherein when the level of the expression product(s) is(are) higher than a reference value this is indicative of a degraded ECM. Methods for the diagnosis and prognosis of cancer and aneurysms are also provided. Furthermore, means for determining the level of expression product of the genes in the above diagnosis or prognosis methods are also provided, as well as kits containing said means.

The invention discloses a rabbit aneurysm model construction method, which comprises the following steps: S1, N different rabbit aneurysm model establishment methods are selected to construct N groups of rabbit aneurysm models, N is an integer greater than or equal to 2, and each model establishment method corresponds to one group of rabbit aneurysm models; s2, measuring the N groups of rabbit aneurysm models obtained in the step S1 by adopting DSA equipment to obtain the short diameter of each group of rabbit aneurysm body; and S3, carrying out comparative analysis on the N groups of rabbit aneurysm body short diameter data obtained in the step S2, and selecting a construction method corresponding to the rabbit aneurysm model with the largest tumor body short diameter to obtain the rabbit aneurysm model. The aneurysm model construction method has the advantages of being high in success rate, convenient to research and the like.

The invention discloses an intracranial aneurysm state prediction model generation method and device, a storage medium and computer equipment; the method comprises the steps: obtaining sample data of a target group, the sample data comprising baseline data, intracranial aneurysm morphological parameters and an intracranial aneurysm rupture state; taking the rupture state of the intracranial aneurysm as an outcome variable, and performing significance analysis on the baseline data item and the intracranial aneurysm morphological item according to the baseline data and the intracranial aneurysm morphological parameters, obtaining a target item with the significance level meeting a preset significance condition in the baseline data item and the intracranial aneurysm morphological item; and constructing an initial prediction model according to the target item, and training the initial prediction model by taking a target parameter corresponding to the target item and the intracranial aneurysm rupture state as model training samples to obtain the intracranial aneurysm state prediction model.

An embolization device and a coil thereof (10, 20, 30) are disclosed. The coil (10, 20, 30) is formed by joining together at least four structural elements arranged in different planes, which include at least two C-shaped elements (12) and at least one O-shaped element (13) or Ω-shaped (11) element. The at least two C-shaped elements (12) are arranged in two adjacent planes and are sequentially joined together to form an S-shaped structure. The embolization device preferably includes plurality of coils (10, 20, 30) which are joined together side-by-side and end-to-end, wherein in any adjacent two coils (10, 20, 30), one is swivelable about an axis of the embolization device with respect to the other. The Ω-shaped element is structurally stable, allowing the coil (10, 20, 30) to maintain good structural stability. At the same time, the three-dimensional S-shaped structure has good deflectability, which imparts high compliance to the coil (10, 20, 30). With this construction, the coil (10, 20, 30) can satisfy the requirements of both stable basket formation and compliant packing and can adapt to various aneurysms of different shapes and sizes with a dense packing effect.