31 results about "Guaianediol" patented technology

The invention discloses a 3-hydroxyisovaleric acid and guaiacol composition and application of the 3-hydroxyisovaleric acid and guaiacol composition in preparation of a medicine for treating or preventing glucose metabolism disorder. The invention provides a strategy for treating metabolic diseases by combining 3-hydroxyisovaleric acid and guaiacol for the first time. It is found that combination of the two has a significant synergistic effect, and combination of low doses is superior to single use of high doses. Systematic animal experiments prove that the traditional Chinese medicine composition has a remarkable effect of improving blood sugar, insulin resistance and fatty liver.

The application discloses 4-propyl guaiacol oxidase mutants, a preparation method and application thereof, wherein wild-type 4-propyl guaiacol oxidase is from Penicillium simplicissimum Penicillium simplicissimum ​ The active center of the wild-type 4-propyl guaiacol oxidase is reformed by using a directed evolution method, and 4-propyl guaiacol oxidase mutants D170E, S426T, S50Q / D170E, D170E / L411V and D170E / L411V / S106C with high activity, cis-trans selectivity and trans-isoeugenol yield are obtained, efficient synthesis of high-value trans-isoeugenol from cheap 4-propyl guaiacol is realized, and the industrialized synthesis and application of the trans-isoeugenol are facilitated.

The invention discloses application of guaiacol in treatment of rheumatoid arthritis, and particularly relates to application of guaiacol in preparation of drugs for treating rheumatoid arthritis. Cell experiments prove that guaiacol can effectively down-regulate expression of proinflammatory factors in macrophages and up-regulate expression of anti-inflammatory factors, and has remarkable anti-inflammatory activity; animal experiments show that the guaiacol effectively relieves rheumatoid arthritis model mouse diseases, and the specific manifestation is that the guaiacol obviously relieves the mouse claw swelling degree, reduces the arthritis disease score, obviously improves joint inflammatory cell infiltration, repairs cartilage injury, inhibits osteoclast generation and reduces the number of joint apoptotic cells; meanwhile, the level of proinflammatory factors in serum of mice can be effectively reduced, and the level of proinflammatory repair factors can be up-regulated. The invention proves that guaiacol has a definite curative effect on rheumatoid arthritis, good biological safety and no obvious side effect, provides a new effective active component for the treatment of rheumatoid arthritis, and has a good prospect of being developed into the medicine for treating rheumatoid arthritis.

The invention discloses a copper molybdate catalyst, a preparation method, application and a method for producing 4-propyl phenol. A preparation method of a copper molybdate catalyst for catalyzing demethoxylation of 4-propyl guaiacol comprises the following steps: mixing water-soluble molybdate, water-soluble copper salt and water to obtain a metal aqueous solution; and concentrating, drying and calcining the metal aqueous solution to obtain the copper molybdate catalyst. The preparation method is simpler to operate and more environmentally friendly, the prepared copper molybdate catalyst can be used for catalyzing 4-propyl guaiacol to remove methoxy so as to produce 4-propyl phenol, and the catalytic performance and stability are excellent.

Use of guaijaverin in preparation of an eye protection product is provided, belonging to the technical field of biomedicine. Use of guaijaverin in preparation of an eye protection product is provided. In Examples, a human retinal primary Müller cell optical damage model, a zebrafish eye damage model by blue light, and a mouse retinal optical damage model are constructed in vitro separately. Based on an eye-protection effect of the guaijaverin, further development may be conducted on drugs for treating retinal optical damage-related diseases and functional products for alleviating visual fatigue.

The present invention relates to lignin comprising beta-O-4'units bound in position to one or more compounds of formula (I), such as phenol, catechol, resorcinol, hydroquinone, pyrogallol and / or guaiacol, a process for its preparation and its use. And lignin fragment 1.

The invention discloses a diatom-loaded amorphous cerium oxide electrocatalyst and a preparation method and application thereof, and relates to the technical field of catalyst material synthesis and biomass value materials.The preparation method comprises the steps that amorphous cerium oxide is dispersed in absolute ethyl alcohol, then metal salt is added for ultrasonic treatment, and a precursor is obtained; and after the treatment is completed, obtaining a precipitate, and calcining the precipitate in an H2 / Ar atmosphere at 500-800 DEG C for 5-10 hours to obtain the diatom-loaded amorphous cerium oxide electrocatalyst. The electrocatalyst prepared by the invention has high atom loading capacity, high selectivity and multiple active sites, and shows excellent electrocatalytic performance when being applied to electrochemical catalysis of guaiacol hydrodemethylation to produce catechol.

The application relates to application of guaiacol or a derivative thereof in preparation of a medicine for preventing or treating metabolic syndrome, and belongs to the technical field of medicines. The guaiacol and the derivative thereof provided by the application can significantly improve insulin resistance conditions by regulating a fat metabolism channel, and can simultaneously reduce inflammatory reaction and oxidative stress damage, and can realize prevention and treatment of metabolic associated steatohepatitis (MASLD), hyperlipidemia, hypercholesterolemia, obesity and diabetes through synergistic action in multiple dimensions.

This invention discloses a highly selective synthesis method for isovlandrin, comprising the following steps: Step S1, reacting guaiacol with a benzylating agent in the presence of an alkaline catalyst and an organic solvent to generate o-benzyloxyanisole; Step S2, reacting the o-benzyloxyanisole with a Vilsmeier-Haack reagent for formylation to obtain 3-benzyloxy-4-methoxybenzaldehyde; Step S3, mixing 3-benzyloxy-4-methoxybenzaldehyde with a 65wt%-70wt% aqueous sulfuric acid solution to perform an acid debenzylation reaction to obtain crude isovlandrin; Compared with the prior art, the yield of isovlandrin can reach up to 70% or more, and the selectivity is greatly improved.

The application discloses a method for in-situ aqueous phase catalytic conversion of guaiacol and lignin into phenolic compounds, and belongs to the technical field of catalytic conversion for preparing phenolic compounds. The method adopts guaiacol or lignin to selectively generate phenol through HDO under the action of a Ni / MgO catalyst. In the absence of external hydrogen and under environmentally-friendly conditions, a one-pot reaction of the Ni / MgO catalyst can obtain a phenolic (phenol and methyl phenol) yield of up to 12.1 wt% from industrial lignin. The application opens up a non-noble metal catalytic strategy, realizes the conversion from renewable lignin resources to phenolic compounds in the absence of external hydrogen, and is consistent with the concept of green chemistry and sustainable development.

The invention belongs to the technical field of guaiacol hydrogenation catalysts, and particularly relates to a mesoporous SiO2 coated Mo2C-Co core-shell nanoparticle catalyst as well as a preparation method and application thereof. According to the invention, Mo2C-Co metal nanoparticles and mesoporous silica coated outside the Mo2C-Co metal nanoparticles are adopted to form a catalyst, and high activity, high stability and unprecedented high cyclohexanol selectivity in a hydrodeoxygenation reaction of guaiacol are realized through a unique core-shell structure (Mo2C-Co core + mesoporous SiO2 shell) and a bimetallic synergistic effect (Mo2C and Co) of the catalyst. The invention not only provides a high-efficiency catalyst for solving the key problem of product selectivity control in biomass conversion, but also opens up a more attractive green path for producing a high value-added chemical cyclohexanol, and has remarkable technical advantages and application prospects.

The invention discloses a catalyst, a preparation method and application thereof, and a production method of 4-propyl phenol. The invention relates to a catalyst for a demethoxylation reaction of 4-propyl guaiacol, which is a Cu-Mo-SiO2 catalyst and is formed by a molybdenum-containing inorganic substance, a copper-containing inorganic substance and a silicon-containing organic substance, based on the total mass of the catalyst, the mass fraction of the Mo element is 14.8-16.3 wt%, and the mass fraction of the Cu element is 0.9-9.8 wt%. The catalyst can be used for catalyzing 4-propyl guaiacol to demethoxylate in a fixed bed reactor so as to generate 4-propyl phenol.

The invention discloses sweet plum essence and a preparation method thereof. The sweet plum essence is prepared from the following components in parts by mass: 0.01 to 0.05 part of eugenol, 0.02 to 0.10 part of alpha damascenone, 0.05 to 0.20 part of beta damascenone, 0.20 to 1.00 part of guaiacol, 0.20 to 1.00 part of myricetin, 0.30 to 1.50 part of ethyl maltol, 5 to 20 parts of dark plum tincture, 5 to 20 parts of jujube tincture and 50 to 90 parts of propylene glycol. The preparation method comprises the following steps: carrying out clarification pretreatment on dark plum tincture and jujube tincture, dissolving ethyl maltol, eugenol, guaiacol, alpha-damascenone and beta-damascenone in propylene glycol at 35-45 DEG C, cooling to not higher than 30 DEG C, adding myricetin, uniformly mixing, adding a clarified tincture, curing for 12-72 hours, and carrying out 0.22-0.45 mu m microfiltration to obtain a finished product. The obtained essence is clear and stable, good in batch consistency, harmonious in sweet plum style level and lasting in aftertaste, and is suitable for aroma enhancement of foods or beverages.

A core-shell structured catalyst comprising: a metal nanoparticle, a non-acidic, spherically shaped inner core, and an acid, spherically shaped outer shell, wherein the metal nanoparticle is supported on the spherically shaped inner core. Also disclosed is a method for preparing the core-shell structured catalyst and use thereof for the hydrodeoxygenation of guaiacol to produce an oxygen-free, polycyclic, high-density fuel precursor.

The guaiacol reaction kettle comprises a reaction kettle main body, a stirring device is arranged in the reaction kettle main body, the top end of the reaction kettle main body is connected with a feeding hopper in a penetrating manner, the bottom end of the reaction kettle main body is connected with a discharging pipe in a penetrating manner, an electromagnetic valve is mounted in the discharging pipe, and the electromagnetic valve is connected with the stirring device. The bottom end of the reaction kettle main body is fixedly connected with a base. By arranging the stirring device and the reaction kettle main body, when raw materials are stirred and two stirring assemblies rotate, the raw materials are scattered and stirred, and the raw materials are driven to be pushed in different directions, so that the raw materials are mixed more fully, and the fusion efficiency of the raw materials is greatly improved; and through the arrangement of the scraping plate, the inner wall of the reaction kettle main body is scraped while the scraping plate rotates along the circumference, so that the situation that the raw materials remain on the inner wall of the reaction kettle main body, and then follow-up stirring of the raw materials with different components is influenced is avoided.

This invention discloses a method for the selective hydrogenolysis of lignin using alumina-supported nickel and nickel-tin alloy catalysts to prepare guaiacol monomers. The method employs a urea precipitation method to prepare a catalyst containing both metallic nickel and a nickel-tin alloy active phase. Organosoluble lignin is used as the raw material, and a mixture of alcohols and water is added as the solvent. The alumina-supported nickel and nickel-tin alloy catalyst prepared by the urea precipitation method is then added. The air in the reactor is replaced with an inert gas, and the pressure is increased to 1.0–3.0 MPa. The reactor is then stirred at 210–270°C for 1–6 hours, resulting in the highly selective conversion of organosoluble lignin into compounds primarily composed of guaiacol monomers. This invention features a simple catalyst preparation process, low cost, and a mild and safe lignin depolymerization reaction. The obtained guaiacol products can be used to prepare food additives or pharmaceutical intermediates and other chemicals.

This invention belongs to the field of catalyst preparation technology, and provides a cobalt-gallium alloy catalyst for the hydrodeoxygenation of guaiacol to cyclohexanol, its preparation method, and its application. The preparation method includes the following steps: First, a mixed metal salt solution of cobalt and gallium sources is prepared, then carbon nanotubes are added, and the mixture is ultrasonically dispersed and refluxed. After the reaction, the catalyst is dried and reduced to obtain the catalyst CoGa / CNTs. Then, the CoGa / CNTs are mixed with an organophosphoric acid ligand solution and reacted at room temperature to obtain the organophosphonic acid ligand-modified carbon nanotube supported cobalt-gallium alloy catalyst R-PA@CoGa / CNTs. Applying the prepared catalyst R-PA@CoGa / CNTs to the hydrodeoxygenation of guaiacol to cyclohexanol achieves excellent guaiacol yield under milder reaction conditions and with a lower active metal content.

This invention relates to a laccase, its mutants, and their applications, belonging to the field of biotechnology. The amino acid sequence of the laccase PnLac1 is shown in SEQ ID NO.2, and the nucleotide sequence is shown in SEQ ID NO.1. The mutants are site-directed mutations at positions 166 (aspartic acid), 348 (histidine), 403 (methionine), or 467 (leucine) of laccase PnLac1, with amino acid sequences shown in SEQ ID NO.4, 6, 8, and 10, and nucleotide sequences shown in SEQ ID NO.3, 5, 7, and 9. The laccase PnLac1 of this invention achieves a decolorization efficiency of 75% for crystal violet within 5 hours. When ABTS was used as a substrate, the enzyme activities of laccase mutants H348F and L467M increased by 1.89 times and 1.65 times, respectively, showing potential for degrading stubborn substances; when guaiacol was used as a substrate, the enzyme activities of laccase mutants D166A and M403F increased by 2.07 times and 3.72 times, respectively, showing high application prospects in the field of lignin.

The application discloses a preparation method of vanillin, and steps include: (1) mixing guaiacol, formyl chloride, carbonate and / or bicarbonate and an organic solvent to generate a nucleophilic substitution reaction, and obtaining a reaction solution containing 2-methoxy-1-formic acid benzyl ester; (2) filtering the reaction solution of step (1), and then adding solid superacid to the reaction solution, so that the 2-methoxy-1-formic acid benzyl ester generates a Fries rearrangement reaction under catalysis of the solid superacid to generate vanillin. The method is simple and efficient, has high atom utilization rate, less waste, and the solid superacid can be used as a Fries rearrangement reaction catalyst to improve the selectivity and conversion rate of the reaction, the catalyst is easy to separate and recycle, the catalyst has long service life, the production cost can be effectively reduced, and the production efficiency is improved.

The invention relates to the field of lignocellulose separation, and relates to a method for separating carbohydrates and lignin from a lignocellulose raw material at near room temperature. The method comprises the following steps: stirring and mixing methanesulfonic acid and guaiacol to obtain a methanesulfonic acid / guaiacol solvent system; the method comprises the following steps: adding a lignocellulose raw material into a methanesulfonic acid / guaiacol solvent system for mixing and stirring reaction to obtain a reaction product; carrying out solid-liquid separation on the reaction product to obtain solid residues and treatment liquid; washing and filtering the solid residues, and drying to obtain pretreated residues; concentrating the treatment liquid to obtain a concentrated solution, adding water and adjusting the pH value to obtain lignin with separated precipitates, and then carrying out solid-liquid separation to obtain pretreated lignin; according to the method, a solvent system composed of methanesulfonic acid and guaiacol is creatively used as a pretreatment solvent, and mild deconstruction-oriented separation of lignocellulose is achieved under the conditions of near room temperature, normal pressure and low corrosion.

The application discloses application of guaiacol in preparation of a drug for treating ulcerative colitis. Cell experiment results show that the guaiacol can enhance the ability of macrophages to remove apoptotic cells; animal experiment results show that the guaiacol can significantly relieve the disease of a dextran sodium sulfate (DSS)-induced ulcerative colitis mouse, and the specific performance is that the guaiacol can slow down the weight loss degree of the colitis mouse, effectively reduce the disease activity index (DAI) of the colitis mouse, significantly inhibit the shortening of the colon of the colitis mouse, the infiltration of inflammatory cells and the mucosal damage, obviously reduce the level of a pro-inflammatory factor in serum of the mouse, and increase the level of a pro-inflammatory repair factor. In conclusion, the guaiacol has definite curative effect on ulcerative colitis, has no obvious side effect, and has a good prospect of being developed into a drug for treating ulcerative colitis.

The invention relates to a linear guaiacol block polyether demulsifier and a preparation method and application thereof.The linear guaiacol block polyether demulsifier is obtained by taking guaiacol as an initiator through an anionic ring-opening polymerization method and reacting guaiacol with epoxybutane, epoxypropane and ethylene oxide in sequence. The linear guaiacol polyether demulsifier prepared by the invention is simple in synthesis process, high in dehydration rate, short in demulsification time and low in oil content of a dehydrated water phase, has a certain viscosity reduction effect, and is suitable for demulsification of mixed oil emulsion.

The invention discloses a 4-ethyl guaiacol derivative and a preparation method thereof, and belongs to the technical field of organic compound synthesis. The invention relates to application of lignite residues as a catalyst to preparation of a 4-ethyl guaiacol derivative. The application comprises the following steps: mixing an aryl diazo ester compound and 4-ethyl guaiacol, adding acetonitrile, and stirring; carrying out a catalytic reaction by using lignite residues as a catalyst, carrying out a standing reaction at room temperature for 1 h, heating to 80 DEG C, and continuing the reaction for 10-12 h; stopping the reaction when the reaction of the raw materials is detected to be complete through TLC; and filtering the reacted raw materials, washing the filter cake with dichloromethane until the filter cake is colorless, carrying out reduced pressure concentration on the filtrate to remove volatile components, and carrying out silica gel column chromatography separation to obtain the 4-ethyl guaiacol derivative. According to the method, the lignite residues are adopted as the catalyst, the problem that the lignite residues are difficult to treat can be solved, a new thought can be provided for selection of the catalyst in the organic synthesis reaction, recycling of waste resources is achieved, and the purposes of green chemistry and environmental protection are achieved.

This application provides a method for preparing a bio-based polyarylate, belonging to the field of high-performance polymer technology. The method involves dissolving guaiacol in an alkaline aqueous solution to obtain an aqueous phase system; dissolving 2,5-furandicarboxylic acid chloride in an organic solvent to obtain an oil phase system; under stirring, the oil phase system is slowly added to the aqueous phase system, controlling the reaction temperature and time. After the interfacial reaction is completed, the mixture is separated, washed, and dried to obtain a bio-based polyarylate with a glass transition temperature of 120–180 °C, a number-average molecular weight of 30,000–80,000 g / mol, and a tensile strength of 60–90 MPa. The bio-based polyarylate prepared by this method exhibits advantages such as good stability and excellent mechanical properties.

The present embodiments relate to mixtures, systems, kits, and methods useful for detecting Alicyclobacillus strains expressing novel genetic variants of the vdcC gene. Alicyclobacillus strains expressing these variants produce guaiacol, which causes spoilage in fruit juice products. The methods and mixtures can be used to predict the spoilage potential of fruit juice products contaminated with Alicyclobacillus.

The application discloses application of fresh bamboo juice effective part in preparation of a medicine for treating chronic obstructive pulmonary disease, and belongs to the technical field of medicines.The fresh bamboo juice effective part contains phenolic substances such as guaiacol, 4-ethylphenol, 4-methylguaiacol, 4-ethylguaiacol, p-vinylguaiacol, 2,6-dimethoxyphenol and dihydroeugenol, and the application has been verified to have the effect of significantly relieving airway mucus hypersecretion caused by the syndrome of external cold and internal fluid retention, can simultaneously inhibit multiple inflammatory factors, and reduce inflammatory infiltration of lung tissue, alleviate emphysema, restore lung tissue elasticity, improve lung function and airway wall thickness, and the like.The application provides a new and effective medicine selection for treatment of chronic obstructive pulmonary disease, and is especially suitable for the disease caused by external cold and internal fluid retention, and has a wide application prospect and important clinical value.

The invention discloses an In2S3-CeO2 / HZSM-5 bifunctional catalyst and an application of the In2S3-CeO2 / HZSM-5 bifunctional catalyst in separation of guaiacol and veratrole. The catalyst is prepared by loading a visible light responsive In2S3-CeO2 heterojunction on an HZSM-5 molecular sieve subjected to pore expansion and surface modification by ammonium nitrate through a hydrothermal-deposition method. The shape-selective adsorption effect of the HZSM-5 molecular sieve can preferentially enrich guaiacol molecules, and the In2S3-CeO2 heterojunction can efficiently activate oxygen to generate active oxygen species under the irradiation of visible light, so that the adsorbed guaiacol is subjected to selective in-situ photocatalytic degradation immediately, and the guaiacol is gradually mineralized into CO2 and H2O. Through the synergistic effect of photocatalysis and adsorption, guaiacol is efficiently and selectively removed, so that the separation selectivity and the purification efficiency of the veratrole product are remarkably improved.

The present application relates to the technical fields of organic chemical synthesis, in particular to a method for synthesizing vanillin by glyoxylic acid method, specifically, taking guaiacol and glyoxylic acid as raw materials, taking molybdenum salt and cobalt salt as a complex metal salt as a catalyst, using step-by-step reaction, first forming guaiacol sodium salt, then reacting with glyoxylic acid, and finally obtaining vanillin. The present application solves the technical problem of low yield of vanillin caused by many by-products of vanillin in the existing process of synthesizing vanillin by glyoxylic acid method.

The purpose of the present invention is to provide a composition that has a favorable flavor that is unique to mustard seeds, such as sweetness, and that has suppressed pungency. Firstly, the present invention relates to a method for producing an oil-based paste-like composition containing pulverized mustard seeds, the method comprising a step of pulverizing the mustard seeds in a mixture of mustard seeds and an oil or fat. Secondly, the present invention relates to an oil-based paste-like composition containing pulverized mustard seeds in which the content of allyl isothiocyanate is significantly lower than that of untreated mustard seeds, and the content of one or more of 2-methyltetrahydrofuran-3-one, 2-furfurylthiol, α-angelica lactone, 2-methyltetrahydrothiophen-3-one, tetrahydrothiophen-3-one, β-angelica lactone, γ-crotonolactone, dimethyl sulfone, furfuryl methyl sulfide, 1-furfuryl pyrrole, and guaiacol is remarkably higher than that of untreated mustard seeds.

The utility model relates to the technical field of synthetic reaction kettles for guaiacol, and discloses a special synthetic reaction kettle for efficiently preparing guaiacol, which comprises a reaction kettle body, a kettle cover mounted above the reaction kettle body, a kettle bottom mounted below the reaction kettle body, and a support frame mounted outside the reaction kettle body, a stirring mechanism is arranged in the reaction kettle body and comprises an upper stirring ring and a lower stirring ring, the upper stirring ring is located above the lower stirring ring, toothed plates are installed at the bottom of the upper stirring ring and the top of the lower stirring ring, and a driving motor is installed on one side of the reaction kettle body; according to the technical scheme, the fusion and reaction effects of materials in the reaction kettle body can be effectively improved through reverse rotation between the upper stirring ring and the lower stirring ring, the materials can be effectively prevented from being deposited on the inner wall of the reaction kettle body, and the practicability of the device is improved.