7 results about "Guaianediol" patented technology

This invention discloses a highly selective synthesis method for isovlandrin, comprising the following steps: Step S1, reacting guaiacol with a benzylating agent in the presence of an alkaline catalyst and an organic solvent to generate o-benzyloxyanisole; Step S2, reacting the o-benzyloxyanisole with a Vilsmeier-Haack reagent for formylation to obtain 3-benzyloxy-4-methoxybenzaldehyde; Step S3, mixing 3-benzyloxy-4-methoxybenzaldehyde with a 65wt%-70wt% aqueous sulfuric acid solution to perform an acid debenzylation reaction to obtain crude isovlandrin; Compared with the prior art, the yield of isovlandrin can reach up to 70% or more, and the selectivity is greatly improved.

The application discloses a method for in-situ aqueous phase catalytic conversion of guaiacol and lignin into phenolic compounds, and belongs to the technical field of catalytic conversion for preparing phenolic compounds. The method adopts guaiacol or lignin to selectively generate phenol through HDO under the action of a Ni / MgO catalyst. In the absence of external hydrogen and under environmentally-friendly conditions, a one-pot reaction of the Ni / MgO catalyst can obtain a phenolic (phenol and methyl phenol) yield of up to 12.1 wt% from industrial lignin. The application opens up a non-noble metal catalytic strategy, realizes the conversion from renewable lignin resources to phenolic compounds in the absence of external hydrogen, and is consistent with the concept of green chemistry and sustainable development.

This invention discloses a method for the selective hydrogenolysis of lignin using alumina-supported nickel and nickel-tin alloy catalysts to prepare guaiacol monomers. The method employs a urea precipitation method to prepare a catalyst containing both metallic nickel and a nickel-tin alloy active phase. Organosoluble lignin is used as the raw material, and a mixture of alcohols and water is added as the solvent. The alumina-supported nickel and nickel-tin alloy catalyst prepared by the urea precipitation method is then added. The air in the reactor is replaced with an inert gas, and the pressure is increased to 1.0–3.0 MPa. The reactor is then stirred at 210–270°C for 1–6 hours, resulting in the highly selective conversion of organosoluble lignin into compounds primarily composed of guaiacol monomers. This invention features a simple catalyst preparation process, low cost, and a mild and safe lignin depolymerization reaction. The obtained guaiacol products can be used to prepare food additives or pharmaceutical intermediates and other chemicals.

This invention belongs to the field of catalyst preparation technology, and provides a cobalt-gallium alloy catalyst for the hydrodeoxygenation of guaiacol to cyclohexanol, its preparation method, and its application. The preparation method includes the following steps: First, a mixed metal salt solution of cobalt and gallium sources is prepared, then carbon nanotubes are added, and the mixture is ultrasonically dispersed and refluxed. After the reaction, the catalyst is dried and reduced to obtain the catalyst CoGa / CNTs. Then, the CoGa / CNTs are mixed with an organophosphoric acid ligand solution and reacted at room temperature to obtain the organophosphonic acid ligand-modified carbon nanotube supported cobalt-gallium alloy catalyst R-PA@CoGa / CNTs. Applying the prepared catalyst R-PA@CoGa / CNTs to the hydrodeoxygenation of guaiacol to cyclohexanol achieves excellent guaiacol yield under milder reaction conditions and with a lower active metal content.

The application discloses application of guaiacol in preparation of a drug for treating ulcerative colitis. Cell experiment results show that the guaiacol can enhance the ability of macrophages to remove apoptotic cells; animal experiment results show that the guaiacol can significantly relieve the disease of a dextran sodium sulfate (DSS)-induced ulcerative colitis mouse, and the specific performance is that the guaiacol can slow down the weight loss degree of the colitis mouse, effectively reduce the disease activity index (DAI) of the colitis mouse, significantly inhibit the shortening of the colon of the colitis mouse, the infiltration of inflammatory cells and the mucosal damage, obviously reduce the level of a pro-inflammatory factor in serum of the mouse, and increase the level of a pro-inflammatory repair factor. In conclusion, the guaiacol has definite curative effect on ulcerative colitis, has no obvious side effect, and has a good prospect of being developed into a drug for treating ulcerative colitis.

This application provides a method for preparing a bio-based polyarylate, belonging to the field of high-performance polymer technology. The method involves dissolving guaiacol in an alkaline aqueous solution to obtain an aqueous phase system; dissolving 2,5-furandicarboxylic acid chloride in an organic solvent to obtain an oil phase system; under stirring, the oil phase system is slowly added to the aqueous phase system, controlling the reaction temperature and time. After the interfacial reaction is completed, the mixture is separated, washed, and dried to obtain a bio-based polyarylate with a glass transition temperature of 120–180 °C, a number-average molecular weight of 30,000–80,000 g / mol, and a tensile strength of 60–90 MPa. The bio-based polyarylate prepared by this method exhibits advantages such as good stability and excellent mechanical properties.

The application discloses application of fresh bamboo juice effective part in preparation of a medicine for treating chronic obstructive pulmonary disease, and belongs to the technical field of medicines.The fresh bamboo juice effective part contains phenolic substances such as guaiacol, 4-ethylphenol, 4-methylguaiacol, 4-ethylguaiacol, p-vinylguaiacol, 2,6-dimethoxyphenol and dihydroeugenol, and the application has been verified to have the effect of significantly relieving airway mucus hypersecretion caused by the syndrome of external cold and internal fluid retention, can simultaneously inhibit multiple inflammatory factors, and reduce inflammatory infiltration of lung tissue, alleviate emphysema, restore lung tissue elasticity, improve lung function and airway wall thickness, and the like.The application provides a new and effective medicine selection for treatment of chronic obstructive pulmonary disease, and is especially suitable for the disease caused by external cold and internal fluid retention, and has a wide application prospect and important clinical value.