The invention provides an AMOLED pixel driving circuit and method realizing voltage and current mixed programming. The AMOLED pixel driving circuit comprises a driving transistor, a first switch transistor, a second switch transistor, a third switch transistor, a capacitor and an organic light-emitting diode. In the programming stage, pixel units are programmed row by row, the first and second switch transistors are switched on in the programming process, the third switch transistor is switched off, a current flows from the driving transistor, the first and second switch transistors to a fixed current signal, and after the programming is finished, the first and second switch transistors are switched off, and the programming of a next row is started; and in a light-emitting stage, the first and second switch transistors are switched off, the third switch transistor is switched on, the current flows from the driving transistor and the third switch transistor to the organic light-emitting diode, and the organic light-emitting diode is driven for emitting light. Through a voltage and current mixed programming mode, comprehensive compensation is carried out on each non-ideal factor of AMOLED pixels, and the programming speed is relatively high, so that the AMOLED pixel driving circuit and method are good in display effect and high in response speed.