The invention relates to the field of coal mining and grouting, in particular to a high-pressure two-alley pre-grouting method for a super deep hole of large geologic structure crack coal-rock mass. The high-pressure two-alley pre-grouting method comprises the following steps of: obtaining a working face histogram, field drilling peeping sights and large geologic structure occurrence or a crack coal-rock mass range in a coal-mining working face; according to a coal-mining geological condition, determining a rock structure, lithology, coal-rock mass strength, geostress field type, a working face extraction process, an advance supporting pressure peak value, periodic weighting length and working face gas drainage layout; according to construction parameters, determining drilling height, a drilling angle, drilling depth, a hole sealing position, hole sealing section number, a hole sealing way and a grouting wall; and performing two-alley grouting according to high-pressure pre-grouting drilling parameters. The high-pressure two-alley pre-grouting method performs grouting reinforcing on coal-rack cracked bodies at different positions, restores integrity of crack coal-rock mass and the geologic structure, improves physical and mechanical properties of the coal-rock mass, improves stability of the crushed coal-rock mass, reduces influences on production, and increases a coal resource recovery rate.