The invention discloses a method and system for determining the train running safety threshold value under coupling of wind, vehicle, road, network, wall and terrain, and therefore the problem that due to the fact that at present, a train overturning coefficient serves as the only criterion for judging wind area driving safety, various influence factors in the actual environment can not be comprehensively considered. The method includes the steps of firstly, determining a first relational expression between the wind speed and a vehicle speed under the state that the road condition, the vehicle type and load, the wind speed and direction and the vehicle speed are coupled, a second relational expression between the critical wind speed and a vehicle speed under the train liter weight ratio critical state, and a third relational expression between the critical wind speed and a vehicle speed under the state that a bow network loses efficacy due to wind-induced network deviation; secondly, obtaining and comparing three vehicle speeds according to the current wind speed during train running and according to the three relational expressions, wherein the minimum vehicle speed is the train running safety threshold value under the environment where a current wind factor, a current vehicle factor, a current road factor, a current network factor, a current wall factor, a current terrain factor and the like are coupled. In this way, the train running safety threshold value determined through the method is closer to the actual environment of train running, and higher reference value is provided for selection of the train running speed.