The invention discloses an air sterilization firework and a manufacturing method thereof. The air sterilization firework comprises raw materials and the manufacturing method; the raw materials include a paper tube, potassium nitrate, sulfur, barium nitrate, an aluminum magnesium alloy, powerful glue powder, potassium perchlorate, an oxidizing agent, a moisture proof agent and Chinese herbal medicines; the weight part of potassium nitrate is 50 g; the weight parts of sulfur, barium nitrate, aluminum magnesium alloy, powerful glue powder, potassium perchlorate, aluminum particles, charcoals, paint pieces, copper oxide and phenolic resins are respectively 3 g; the weight part of oxidizing agent is 3 g; the weight part of moisture proof agent is 7 g; and the weight part of Chinese herbal medicines is 10 g. The air sterilization firework and the manufacturing method thereof are lower in manufacturing cost, simple in operation and suitable for mass production, can remove bacteria and virus in air besides of enjoyment, are not easy to bomb a drum, and are better in setting-off effect.