The invention belongs to the technical field of energy-saving building materials, and particularly discloses a building energy-saving wall enclosure OSB cladding structure insulation board. The cladding structure insulation board comprises an XPS core board, an upper surface board arranged on one side of the XPS core board and a lower surface board arranged on the other side of the XPS core board,wherein an upper cladding board is arranged between the XPS core board and the upper surface board, a lower cladding board is arranged between the XPS core board and the lower surface board, the upper cladding board and the lower cladding board are OSB boards, he upper surface board and the lower surface board are light calcium silicate boards, and the boards are bonded through a single-componentreactive polyurethane adhesive. The cladding structure insulation board has the characteristics of high efficiency, energy conservation, moisture resistance, water resistance, fire prevention, good sound insulation, simple structure, convenience in production, manufacturing, use and installation and long service life, and has a very good market application prospect.