The invention relates to a preparation method for preparing a derived fuel by utilizing combustible materials in garbage, comprising the following steps: (1) disinfecting; (2) carrying out rough selection on the garbage; (3) carrying out fine selection on the garbage; (4) adding CaO the weight of which accounts for 4%-8% of the total weight of the combustible materials into fine combustible materials, mixing and stirring uniformly; (5) adding a combustion improver and an adhesive, mixing and stirring uniformly; (6) draining and drying the fine combustion materials; (7) carrying out extrusion molding; (8) drying and cooling to obtain a finished product; and (9) detecting the heating value of the derived fuel. The preparation method has the beneficial effects that 1, the sorting index of the garbage is high, so that harmful substances in the derived fuel are effectively controlled; 2. the heat value of the derived fuel is high; 3, the CaO is added in the derived fuel of the garbage, effective disinfection is achieved and the generation of the harmful substances such as dioxin and the like in the combustion process is restrained; 4, the adhesive is added, so that the strength of a product is good, the product is not easy to break, and the structure shape is smooth; 5, the space formed by accumulation of the size of the shape of the finished product on a boiler grate is most beneficial to combustion; and 6, the resource utilization is maximized, the cost of production and manufacture is low, the production efficiency is high, the product quality is good, and the transportation and storage are convenient.