94results about How to "Medicinal effect" patented technology

[Problem]To provide a novel polymer derivative of a cytidine metabolic antagonist which allows release of a medicament irrespective of enzymes of the living body and is expected to have high therapeutic effects.[Solution]The polymer derivative of a cytidine metabolic antagonist in which a substituent represented by the general formula (I) or the general formula (II) [wherein R7 and R8 each independently represent a hydrogen atom or an optionally substituted (C1-C6)alkyl group, R6 represents a hydrogen atom, an optionally substituted (C1-C40)alkyl group, an optionally substituted (C1-C40)aralkyl group, an optionally substituted aromatic group, an amino acid residue in which the carboxy group is protected, or an optionally substituted sugar residue, CX—CY represents CH—CH or C═C (double bond), and A represents the residue of the cytidine metabolic antagonist except the amino group at the position 4] is bonded to the side-chain carboxy group of a block copolymer of a polyethylene-glycol structural moiety and a polymer having 10 or more carboxy groups.

[Problem]To provide a novel polymer derivative of a cytidine metabolic antagonist which allows release of a medicament irrespective of enzymes of the living body and is expected to have high therapeutic effects. [Solution]The polymer derivative of a cytidine metabolic antagonist in which a substituent represented by the general formula (I) or the general formula (II) [wherein R7 and R8 each independently represent a hydrogen atom or an optionally substituted (C1-C6)alkyl group, R6 represents a hydrogen atom, an optionally substituted (C1-C40)alkyl group, an optionally substituted (C1-C40)aralkyl group, an optionally substituted aromatic group, an amino acid residue in which the carboxy group is protected, or an optionally substituted sugar residue, CX—CY represents CH—CH or C═C (double bond), and A represents the residue of the cytidine metabolic antagonist except the amino group at the position 4] is bonded to the side-chain carboxy group of a block copolymer of a polyethylene-glycol structural moiety and a polymer having 10 or more carboxy groups.

The invention is a antiinflammation pain easing and granulation promoting plaster, it is made up of following Chinese traditional medicine materials and weight shares: calamus 10-20, red-rooted salvia root 10-15, goat horn powder 20-40, buffalo horn powder 20-40, antilope horn powder 20-50, sun cuphorbia 10-30, dahurian patrinia 20-50, selfheal 20-40, plaster 20-30, mastic 10-20, myrrh 10-20, scorpion 15-50, centipede 15-30, muskiness 2-4, borneol 10-30, tangerine seed 20-40, zhebei 20-40, weeping forsythia 20-50, silkworm 20-40, Chinese scholartree skin 100-150, elephant skin 10-13, nvtongfatan 5-7, and uses 30-50 of toad to extract the arenobufagin. It has functions of antiinflammation and pain easing, pus drainage and muscle promoting, heat clearing and toxin decomposing, qi ventilating.

The invention discloses an anti-aging composition for cosmetics. The composition is prepared from, by weight, 10-20 parts of benzoinum, 6-15 parts of rutin, 8-15 parts of herba lycopi, 15-25 parts of rhizoma panacis japonici, 15-24 parts of Indian mockstrawberrg herb, 5-10 parts of roots of jasminum officinale and 8-15 parts of herba lycopodii. According to the anti-aging composition for the cosmetics, the synergistic enhancing effect among the raw materials is achieved, the anti-aging effect of the composition is increased, the drug efficacy is mild, the composition is formed by combining pure natural plant extracts, the side effect is small, the adaptability is wide, and the cost is low.

The present invention relates to a composition for inhibiting after-cataract including a hydrophilic sulfasalazine; a high content of hyaluronic acid; and a carrier containing an aqueous solution, and a method of preparing a composition for inhibiting after-cataract including the steps of adding hyaluronic acid powder to a hydrophilized sulfasalazine; and mixing the same with a specific condition.

The invention discloses a cistanche-deserticola-containing whitening traditional Chinese medicine composition for cosmetics. The composition is prepared from, by weight, 10-18 parts of rhizoma cyperi, 20-30 parts of cistanche deserticolam 10-15 parts of vaccinium myrtillus, 6-10 parts of schisandra propinqua, 0.2-0.5 part of licorice root and 6-9 parts of cydonia oblonga. According to the composition, as compatibility of the raw materials is optimized, the synergistic interaction effect is generated among the raw medicinal materials, the whitening effect of the composition is improved, the medicine effect is mild, the composition is combined by pure natural plant extracts, the side effect is small, the adaptability is wide, and cost is low.

The invention discloses a whitening traditional Chinese medicine composition containing terminalia bellerica fruit and used for cosmetics. The composition is prepared from, by weight, 10-18 parts of morus australis, 20-30 parts of terminalia bellerica fruit, 10-15 parts of red-knees herb, 6-10 parts of semen raphani, 0.2-0.5 part of alpinia coriandriodora and 6-9 parts of gingkoes. By optimizing compatibility of the raw materials, raw material medicines of the composition have a synergistic interaction effect, the whitening effect of the composition is improved, the medicine effect is mild, and the composition is formed by combining pure natural plant extracts and is small in side effect, wide in adaptability and low in cost.

The invention provides a traditional Chinese medicine composition for acne-removing cosmetics. The composition is prepared from the following raw materials in parts by weight: 15 to 25 parts of spicaprunellae, 8 to 12 parts of herba artemisiae capillariae, 3 to 7 parts of clover herb, 10 to 15 parts of rosa multiflora fruit, 3 to 5 parts of liquorice root, 6 to 10 parts of oatmeal, 6 to 8 parts of acacia farnesiana root and 8 to 10 parts of radix scutellariae. According to the traditional Chinese medicine composition, traditional Chinese medicine components including the spica prunellae, theclover herb, the liquorice root, the radix scutellaria and the like are used as an acne-removing main body, are pure natural traditional Chinese medicines, are moderate and have no toxin or irritation; moreover, the herba artemisiae capillariae, the rosa multiflora fruit, the oatmeal and the acacia farnesiana root are used as ministerial drugs; all matched medicinal materials have a synergetic effect and have the effects of killing propionibacterium, conditioning skin metabolism, detoxifying and diminishing inflammation, improving skin antianaphylaxis and the like, so that the effects of rapidly removing acnes and contiguously removing the acnes are realized and the acne removing effect is better; the traditional Chinese medicine composition has a moderate medicinal effect and no side effect and is suitable for various skin types.

The invention discloses an anti-aging traditional Chinese medicine composition containing scrophularia ningpoensis for cosmetics. The composition is prepared from the following raw materials in parts by weight: 15-20 parts of selfheal, 10-20 parts of scrophularia ningpoensis, 10-15 parts of liquorice, 20-30 parts of passion fruits, 5-10 parts of turmeric, 5-10 parts of lalang grass rhizome and 10-15 parts of ficus pumila. According to the composition, through the synergistic effect among the raw materials, the anti-aging effect of the composition is increased; the composition is compounded by purely natural plant extracts with a mild medicine effect; the composition is small in side effect, wide in adaptability and low in cost.

The invention discloses a traditional Chinese medicine composition containing cerasusssp and applied to acne removing cosmetics. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of artemisia capillaries, 20 to 30 parts of cerasusssp, 10 to 15 parts of rosa multiflora, 6 to 10 parts of avena sativa, 2 to 5 parts of glycyrrhiza uralensis, and 6 to 9 parts of cassie root. The traditional Chinese medicine composition ensures that crude drugs produce synergistic interaction through the optimization of material combination, enhances the acne removing effect, and is mild in drug efficacy, formed by extracting and combining pure natural plant extracts, small in side effect, wide in adaptability and low in cost.

The invention discloses a traditional Chinese medicine for treating liver cirrhosis. The traditional Chinese medicine for treating liver cirrhosis is composed of the raw material medicines by weight: 180 g of curcuma aromatica, 300 g of oriental wormwood, 120 g of elecampane, 120 g of pericarpium citri reticulatae viride, 120 g of rhizoma cyperi, 120 g of fingered citron, 120 g of fried fructus aurantii, 300 g of fried white atractylodes rhizome, 120 g of prepared astragalus membranaceus, 300 g of poria cocos, 180 g of pawpaw, 180 g of pericarpium arecae, 150 g of radix paeoniae alba, 90 g of cortex moutan, 300 g of lalang grass rhizome, 120 g of rhizoma corydalis, 90 g of cinnamon, 200 g of fructus forsythiae, 60 g of prepared licorice and 20 g of horse mane. The honeyed pills are tender and smooth, gentle in effects, lasting in efficacy, convenient for keeping medicine properties, convenient to take, carry and store, and free from the shortages of cumbersome decoction, difficulty in taking due to bitter taste, and inadaptability to placement for a long time of traditional Chinese medicines.

The invention discloses bream feed capable of improving disease resistance. The bream feed is prepared from components as follows: corn flour, soybean dregs, black bean powder, wheat middling, a nutrient enhancer, an attractant, a disease resistant agent and table salt, wherein the disease resistant agent is prepared from raw materials in parts by weight as follows: 3-5 parts of radix sophorae flavescentis, 1-3 parts of eupatorium adenophorum, 1-3 parts of green tea, 5-10 parts of fermented bread, 10-20 parts of wort, 1-3 parts of aquilegia viridiflora, 1-3 parts of lyonia leaves, 1-3 parts ofherba corydalis, 1-3 parts of gnaphalium affine, 10-15 parts of distillers' grains, 10-20 parts of milk, 10-20 parts of butter, 2-5 parts of chicken paste, a microbial agent and an enzymatic preparation; the microbial agent is prepared from raw materials as follows: Raman lactobacillus, gram-positive vacilli, bacillus mucilaginosus, actinomycetes and saccharomycetes; the enzymatic preparation comprises bromelin and amyloglucosidase. The bream feed has the benefits of improving disease resistance of bream, increasing the survival rate, promoting bream weight increase and improving the bream quality.

An HA-protein conjugate in which an HA-aldehyde derivative, in which an aldehyde group is introduced to a hyaluronic acid or a salt thereof, is conjugated to the N-terminus of a protein, and a method for preparing the same are provided. The HA-protein conjugate includes a protein drug exhibiting an excellent bioconjugation efficiency and long-term medicinal effects, and has excellent protein drug activities since the hyaluronic acid is specifically conjugated to the N-terminus of the protein. Also, since liver-targeting properties of the hyaluronic acid can be freely controlled by changing an aldehyde substitution rate of the HA-aldehyde derivative, the HA-protein conjugate can be effectively used as a protein drug for treating liver diseases, and also be useful in enabling long-term medicinal effects of a protein drug required to bypass the liver. Accordingly, the HA-protein conjugate can be effectively used for a drug delivery system of proteins.

The invention discloses a whitening traditional Chinese medicine composition containing adenophora tetraphylla fisch and used for cosmetics. The composition is prepared from, by weight, 10-18 parts of cydonia oblonga, 20-30 parts of adenophora tetraphylla fisch, 10-15 parts of ficus religiosa, 6-10 parts of morus australis, 0.2-0.5 part of radix angelicae pubescentis and 6-9 parts of radix angelicae sinensis. By optimizing the compatibility of the raw materials, the raw medicine materials have synergistic interaction, the whitening effect of the composition is added, medicine effects are mild, and the composition which is prepared by compounding pure natural plant extracts is small in side effect, high in adaptability and low in cost.

The invention belongs to the field of skin care and particularly relates to a plant extract having an acne removal function and a preparation method and application thereof. The plant extract having the acne removal function is prepared from raw material ingredients including marigold, achillea sibirca, pomegranate peel, licorice roots, rhizoma coptidis and coptis chinensis. The raw materials are reasonable in compatibility, different effective active ingredients produce a synergistic effect, the medicinal properties of the effective active ingredients are greatly excited, a medical effect is mild, no side effect is produced, and the plant extract integrates pore clearing, hair follicle clearing, oil secretion reduction, skin oil absorption and oil secretion balancing and has the effects of preventing and dissolving acnes, reducing hyperpigmentation, reliving skin inflammation and reducing cutaneous sensibility. In addition, the extract further has the effects of playing super-strong heating capability, sterilizing, astringing a wound, treating and preventing inflammation, pimples, coarse pores and scars and repairing the scars, can rapidly kill epidermis bacteria, hair follicle root bacillus and the like and has bacterium resistance and bacteriostasis effect.

The invention discloses a traditional Chinese medicine composition containing frankincense and used for anti-freezing and anti-chap cosmetics. The composition is prepared from, by weight, 10-20 parts of pagodatree flower bud, 20-30 parts of frankincense, 10-15 parts of Rhizoma et Radix Notopterygii, 6-10 parts of asparagus cochinchinensis, 2-5 parts of licorice root and 6-9 parts of resina draconis. By optimizing the compatibility of raw materials, raw medicine materials have a synergistic effect, the anti-freezing, anti-chap and moisturizing effects of the composition are improved, medicine effect is mild, and the composition is prepared from pure natural plant extracts and is small in side effect, high in adaptability and low in cost.

The invention discloses healthcare rice wine. The healthcare rice wine is prepared from, by weight, 100-150 parts of glutinous rice, 50-80 parts of persimmon leaves, 20-50 parts of rhizoma dioscoreae, 5-10 parts of orthosiphon wulfenioides, 10-20 parts of fructus lycii, 10-15 parts of corn stigma, 5-10 parts of radix notoginseng and 5-10 parts of poria cocos. The healthcare rice wine has advantages that by effective combination of natural medicines and the glutinous rice, joint functions of all components, mild efficacies and non-toxic side effects are realized, and medicine and food homology is truly achieved; in addition, the healthcare rice wine is great in taste and high in nutritive value, has functions of body immunity improvement, blood pressure regulation, diuresis promotion, bowel relaxing, kidney function improvement and physique enhancement and also has certain treatment and healthcare effects on diabetes and kidney diseases.

The invention discloses a traditional Chinese medicine composition containing pseudo-ginseng and used for anti-freezing and anti-chap cosmetics. The composition is prepared from, by weight, 10-20 parts of fruits of hovenia dulcis thunb., 20-30 parts of pseudo-ginseng, 10-15 parts of radix arnebiae seu lithospermi, 6-10 parts of tremella fuciformis, 2-5 parts of rhizoma cyperi and 6-9 parts of fructus rubi. By optimizing the compatibility of raw materials, raw medicine materials have a synergistic effect, the anti-freezing, anti-chap and moisturizing effects of the composition are improved, medicine effect is mild, and the composition is prepared from pure natural plant extracts and is small in side effect, high in adaptability and low in cost.

The invention provides farmyard manure granules and a preparation method thereof. The farmyard manure granules comprise the following raw materials by weight: 50 to 60 parts of human excrement, 30 to40 parts of pig manure, 10 to 20 parts of a cake fertilizer, 10 to 20 parts of soybean straw, 10 to 15 parts of urea formaldehyde, 10 to 15 parts of calcium superphosphate, 15 to 20 parts of modifiedvermiculite, 15 to 20 parts of humic acid, 2 to 3 parts of pericarpium papaveris powder, 6 to 10 parts of a biological fermentation inoculum, 8 to 10 parts of alum, 2 to 3 parts of radix stemonae, 2 to 3 parts of sodium fluorosilicate and 30 to 50 parts of an auxiliary material. The farmyard manure granules provided by the invention can achieve the purpose of killing bacteria and insects in farmyard manure without undergoing the process of high-temperature fermentation; a decomposition promoter in a fertilizer can promote decomposition of an organic fertilizer and facilitates absorbing the fertilizer for a crop; and through mixing of the farmyard manure and a chemical fertilizer, the synergistic effect of the fertilizer can be effectively enhanced.

The invention discloses a traditional Chinese medicine containing cherry blossoms and used for skin whitening cosmetics. The composition is prepared from, by weight, 6-12 parts of bletilla striata, 10-20 parts of cherry blossoms, 8-16 parts of evening primrose, 6-10 parts of radix scutellariae, 2-10 parts of liquorice root and 5-15 parts of poria cocos. By means of the synergetic enhancement action of all medicine raw materials, the skin whitening effect of the composition is enhanced, the pharmacological function is mild, and the traditional Chinese medicine composition is formed by combining pure natural plant extracts, is high in adaptability and low in cost and has few side effects.

The invention belongs to the technical field of traditional Chinese medicines and discloses an internal traditional Chinese medicine composition for treating cervical vertebra and lumbar vertebra painand a preparation method thereof. The composition comprises the following raw materials in parts by weight: salt processed eucommia ulmoides, astragali radix in North, flos carthami, vinegar processed tortoise plastron, mulberry twigs, rhizoma seu radix notopterygii, wine processed dipsacus roots, stir-fried dried orange peel, ginseng, vinegar processed corydalis tuber, radix angelicae pubescentis, cassia twigs, salt processed semen cscutae, semen coicis, asarum heterotropoides, kalimeris indica seeds, fructus chaenomelis lagenariae, scorpio, herba taxilli, radix clematidis, radix gentianae macrophyllae, rhizoma dioscoreae nipponicae, radix puerariae, sea-buckthorn, wine processed rhizoma chuanxiong, centipede, radix paeoniae alba, radix cynanchi panicullati, panax notoginseng, cortex cinnamomi, herba cistanche, radix angelicae sinensis, stir-fried fructus foeniculi, stir-fried fructus aurantii, agilawood, radix saposhnikoviae, salt processed core-removed morinda officinalis, fructusamomi, radix rehmanniae preparata, hot cibotium barometz, deer-horn glue, rhizoma gastrodiae, semen juglandis, caulis tinosporae sinensis, common fenugreek seeds stir-fried with salt water and wine processed radix cyathulae. The preparation method comprises the following steps: A, decocting the raw material medicines many times, concentrating and evaporating to prepare concentrated granules for future use. The internal traditional Chinese medicine composition for treating cervical vertebra and lumbar vertebra pain has the characteristics of being convenient to take, stable in curative effect and not liable to relapse.

A Chinese medicine 'Chunyang Zhengqi' capsule based on 'Chunyang Zhengqi' pill for treating acute enterogastritis is prepared from cablin pachouli, pinellia tuber, etc.

A fish soup for eliminating hysteromyoma is proportionally prepared from living turtle, grayling, crucian carp, Spinibarbus sinensis, blackfish, grass carp, American ginseng, red jujube, rice wine, milk, ginger, salt, tea oil and water.

The invention discloses a method for preparing health care dried soya cream. The method comprises the processes of taking bean raw materials, debarking, soaking, mixing, grinding, filtering, deslagging, boiling, peeling, and extracting dried soya cream. The method is characterized in that during the boiling process, 0.1 to 0.2% of food grade sorbitol, 0.1 to 0.5% of DATEM, and 1 to 15% of red jujube powder are added according to raw material weight; the sorbitol and the DATEM are used together, so that the output rate is effectively improved, and meanwhile the product quality is greatly improved; 1 to 15% of red jujube powder is added to prepare the health care dried soya cream product.

The invention discloses a dandruff removal traditional Chinese medicine composition containing tropaeolum majus and used for cosmetics. The composition is prepared from, by weight, 8-16 parts of hemerocallis fulva, 15-25 parts of tropaeolum majus, 6-12 parts of althaea officinalis, 4-9 parts of phellodendron amurense, 0.2-0.5 part of licorice root and 3-7 parts of galla chinensis. By optimizing the compatibility of the raw materials, the raw medicine materials have synergistic interaction, the dandruff removal effect of the composition is added, medicine effects are mild, and the composition which is prepared by compounding pure natural plant extracts is small in side effect, high in adaptability and low in cost.

The invention discloses an entada phaseoloides containing anti-dandruff Chinese medicinal composition for cosmetics. The composition is prepared from the following raw materials by weight: 8-16 parts of Amomum kravanh, 15-25 parts of entada phaseoloides, 6-12 parts of flower of Aztec marigold, 4-9 parts of equisetum arvense, 0.2-0.5 part of eucommia, and 3-7 parts of Cynanchum atratum. Through optimization of the raw material compatibility, the bulk drugs can reach a synergistic effect so as to increase the anti-dandruff effect of the composition. The composition has mild efficacy, is formed by combination of pure natural plant extracts, and has the advantages of small side effect, wide adaptability, and low cost.

The invention discloses a face cream capable of removing spots and a preparation method of the face cream. The face cream is prepared from the following raw materials in parts by weight: 3-6 parts ofcetanol, 2-4 parts of glycerin monostearate, 1-3 parts of sodium alginate, 4-8 parts of glycerinum, 2-5 parts of polysorbate, 2-5 parts of propanediol, 1-3 parts of triethanolamine, 3-6 parts of composite Chinese herbal medicinal ingredient and 65-85 parts of deionized water. The pH value of the face cream is 7.5-8.0. The composite Chinese herbal medicinal ingredient has the advantages of synergistic interaction, good permeability, easiness in absorption and the like. Metabolism of melanin is accelerated while melanin formation in skin cells is inhibited effectively, and therefore, the spots can rapidly face away or disappear; and the face cream is gentle in effect, is good in spot removing effect, and does not have toxic or side effects.

The invention discloses a drug composition for treating hyperthyroidism and a preparing method thereof. The composition achieves the functions of managing qi and activating blood through the root of red-rooted salvia, the rhizome of chuanxiong, radix paeoniae rubra, citri reticulatae viride and radix aristolochiae; the drug composition achieves the function of adjusting physiological functions through calculus bovis, fel ursi, crocus sativus and radix notoginseng; the drug composition achieves the functions of eliminating hardness and removing stasis through cornu saigae tataricae, concha arcae, pangolin scales, seaweed, kelp, rhizoma sparganii, rhizoma curcumae and spina gleditsiae; the drug composition achieves the functions of dissolving toxin and discharging dirt through arisaema cum bile, semen brassicae, thunberg fritillary bulb, honeysuckle flowers, fructus forsythiae, prunella vulgaris, herba scutellariae barbatae and raw rheum officinale; the drug composition relieves internalheat or fever through liquorice root, all the medicinal materials are coordinated to play the outstanding synergistic function of treating hyperthyroidism. According to the drug composition, throughthe synergistic effects of all the raw materials, the drug effects supplement each other to bring out the best part in each other; through dispersing of the liver and rectifying of qi, hyperthyroidismand complications are fundamentally treated, and the immunological function of the body of a patient can also be added.

The invention discloses a medicine for treating respiratory system diseases and a preparation method and a use method of the medicine and belongs to the field of traditional medicines. The medicine for treating the respiratory system diseases comprises scorzonera austriaca, aster tataricus, platycodon grandiflorum, fritillaria pallidiflora, dried ginger, pepper, cinnabar, radix glycyrrhiza and flos farfarae. The invention further discloses a preparation method and a use method of the medicine. According to the medicine for treating respiratory system diseases and the preparation method and the use method of the medicine, common traditional Chinese medicines are adopted as raw materials, the medicinal formula is simple, and with the combination of the traditional Chinese medicines, the medicine has the effects of moistening dryness and removing stasis, eliminating phlegm, tonifying lungs, eliminating inflammation, dredging collaterals, dispelling coldness and dredging dampness, stopping cough, opening chests, improving lung blood circulation and removing toxin, has the characteristics of being simple in preparation method, also simple in use method, long in preservation time, convenient to carry over, remarkable in treatment effect, mild in medicinal effect, small in toxic and side effect and the like, and is capable of effectively treating the respiratory system diseases.

The invention discloses Radix Paeoniae Alba compound tea with effect of reducing blood fat. The compound tea is prepared from the following raw materials in parts by weight: 15-30 parts of Radix Paeoniae Alba, 15-30 parts of Herb Gynostemmae Pentaphylli, 5-15 parts of hawthorn, 5-10 parts of mint, 3-8 parts of flower of Radix Notoginseng and 2-6 parts of Rhizoma Imperatae. According to the compound tea, combination of the raw materials is optimized, so that raw herbal materials have synergistic interaction effect; the blood fat reducing effect of the compound tea is improved; taste is also improved; the effect is gentle; and the compound tea does not have toxic or side effects, and is suitable for all people suffering from hyperlipidemia to drink for a long time.