Provided is a power distribution network intelligent soft switch operation optimization method with simultaneous consideration of switch motion. According to a power distribution system, connection relation of circuit parameters, load level and network topology, system operation voltage level and branch current restriction, distributed power supply connection position, type, capacity and parameters, intelligent soft switch connection position, capacity and parameters, load and distributed power supply operation characteristic prediction curves in an operation optimization cycle, a system reference voltage and a reference power initial value are input; a sequential optimization model of cooperation operation of a power distribution network connection switch and an intelligent soft switch is established; conic model conversion of an object function and non-linear constraints in the sequential optimization model of cooperation operation of the power distribution network connection switch and the intelligent soft switch is carried out according to a conic optimization standard form; linearization of the object function is carried out, the non-linear constraints are converted into linear constraints, second order cone constraints or rotary cone constraints, and solving of the obtained mathematic model is carried out through a CPLEX solver. The provided method avoids tedious iteration and a lot of tests.