13 results about "Retinol palmitate" patented technology

The invention belongs to the technical field of compositions, and provides a moisture-retaining and eye-moistening composition as well as a preparation method and application thereof. According to the moisturizing eye-moistening composition provided by the invention, the soybean lecithin, the retinol palmitate lipidosome, the xanthophyll, the oligomeric hyaluronic acid and the ethylenediamine tetraacetic acid in a specific ratio are combined, and all the components can play a good synergistic effect, so that the effects of relieving asthenopia symptoms, protecting eyesight and maintaining normal vision are improved; the eye drops can improve and relieve eye dryness and eye astringency symptoms caused by various reasons (such as fatigue, wearing of contact lenses, use of electronic products, excessive use of eyes and the like).

Cosmetic composition, e.g. an anti-ageing composition, comprising retinyl palmitate (pref. 0.25-0.5 wt.%), Silybum marianum seed oil (pref. 1-3 per cent by weight), betaine (pref. 2-4 weight per cent)

The application belongs to the technical field of cosmetics and skin external preparation, and discloses a retinoid, a preparation method and application thereof. The compound is formed by covalently coupling a Schiff base or a kinin releasing enzyme cleavable peptide bond (L) and a free L-amino acid, a di- to hexapeptide or a C6-C22 fatty acid ester (P) of the retinol parent (R), and the structural general formula is R-L-P. The compound has a 12-week stability rate of ≥80% in a 25℃ aqueous preparation, is recognized by a keratin layer carboxylic acid esterase and a kinin releasing enzyme KLK-5 / KLK-7 after being applied to the skin, is subjected to enzymatic cutting in a skin acidic cuticle (pH 4.5-5.5) microenvironment, and releases free retinol at a fixed point. Compared with retinol palmitate, the in-situ release efficiency of the compound of the application is increased by 2.5-4.5 times, while the risk of systemic absorption is significantly reduced, and the incidence of sensitive skin irritation is ≤6.7%.

The invention relates to a traditional Chinese medicine extract composition for facial skin care, which is prepared by compatibility of raw radix astragali, stiff silkworm, radix angelicae, safflower and other traditional Chinese medicines through a supercritical CO2 extraction and alcohol extraction-water extraction combined process, the total flavone content is greater than or equal to 22%, and the total phenolic acid content is greater than or equal to 16%. The composition realizes a multi-target synergistic effect through a triple mechanism of tonifying qi and activating blood, soothing the liver and relieving depression, and detoxifying and repairing; the composition is capable of whitening and fading spots, inhibiting tyrosinase and reducing melanogenesis by 38%; hormonal dermatitis is repaired, the TEWL value is reduced by 28%, and IL-6 secretion is inhibited by 41%; anti-aging: promoting the expression of type I collagen to be increased by 42%, and improving the depth of wrinkles by 29%. The composition cooperates with modern active ingredients such as retinol palmitate and hexapeptide, and innovative carriers such as biological fiber membrane cloth (the oxygen permeation rate is increased by 3 times) and freeze-dried powder dosage forms are carried, so that efficient permeation and stability are ensured. The composition is suitable for whitening skin care products, hormonal dermatitis treatment products and anti-aging preparations, and solves the problems of single efficacy and insufficient safety in the prior art.

A whitening nanocomposition, a preparation method therefor, and use thereof. The whitening nanocomposition comprises an active ingredient and a nanocarrier. The active ingredient is coated and / or adsorbed by the nanocarrier. The active ingredient comprises the following components: 1-15 parts by weight of α-arbutin, 1-15 parts by weight of nicotinamide, 1-10 parts by weight of 3-o-ethyl ascorbic acid, 0.1-1 part by weight of a Centalla asiatica extract, and 1-5 parts by weight of retinyl palmitate. The nanocarrier comprises the following components: 5-10 parts by weight of an emulsifier, 5-20 parts by weight of a polyol, 0.1-5 parts by weight of a phospholipid, and 40-60 parts by weight of water. The whitening nanocomposition has good skin permeability and retention performance and enables high-concentration enrichment, prolonged retention, and sustained release or controlled release within a target tissue, so as to be effectively taken in by target cells, thereby improving bioavailability and enhancing the whitening effect.

The application belongs to the technical field of compositions, and provides a moisturizing eye composition, a preparation method and application thereof. The moisturizing eye composition provided by the application is combined by soybean lecithin, retinol palmitate liposome, lutein, oligomeric hyaluronic acid and ethylenediaminetetraacetic acid in a specific ratio, and good synergies can be achieved among the components, the effect of relieving asthenopia, protecting eyesight and maintaining normal vision is improved, and the effect of improving and relieving the symptoms of dry eyes and dry eyes caused by various reasons (such as fatigue, wearing contact lenses, using electronic products, overuse of eyes, etc.) is improved.

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to Yarrowia lipolytica engineering bacteria for producing retinol, retinyl ester and derivatives thereof as well as a fermentation method and application of the Yarrowia lipolytica engineering bacteria. Specifically, firstly, yarrowia lipolytica is modified, beta-carotene 15, 15 '-oxygenase and retinol dehydrogenase from different host sources are screened, the copy number of key genes in a metabolic pathway is adjusted, the metabolic flux of a precursor is enhanced, the yield of retinol is increased, and meanwhile, the yield of retinol is increased by optimizing culture conditions. Therefore, the content of retinol is increased, and direct biosynthesis of retinol palmitate is finally realized by adjusting a carbon source and introducing retinol binding protein. In a word, a yarrowia lipolytica platform for efficiently synthesizing the retinol and the retinol ester is designed, and a foundation is laid for sustainable industrial production of the retinol and the retinol ester, so that the yarrowia lipolytica has excellent practical application value and application prospect.

The disclosed invention relates to a chemical composition that can be taken orally and supplements an unhealthy diet and lifestyle. In one aspect of the invention the chemical composition includes Retinol Palmitate, Thiamine, Riboflavin, Niacin, Nicotinamide mononucleotide (NMN), Pyridoxal, Folic Acid, Cyanocobalamin, Cholecalciferol, Zinc, Manganese, Copper, Calcium, Magnesium, Iron, L-Selenomethionine, Lysine, Phenylalanine, L-Threonine, L-Methionine, L-Histidine, L-Tryptophan, L-Leucine, L-Isoleucine, L-Valine, Cinnamon Bark Powder, and Curcumin.

The invention belongs to the field of functional lipid enzymatic preparation, and particularly relates to a method for preparing retinol palmitate through pH response type Pickering interfacial enzyme catalysis. Aiming at the problem that the high stability of the Pickering emulsion is not beneficial to product separation and catalyst recovery and cyclic utilization, a pH response type PIB system is designed and prepared, and reversible switching between demulsification and emulsification of the O / WPickering emulsion is realized through acid-base regulation and control. The method can be widely used for transesterification of medium / long-chain fatty acid and retinol acetate to generate retinol fatty acid ester, and the obtained product has better antioxidant activity than retinol acetate and can meet the requirements of different application scenes; an emulsion enzyme catalysis system is adopted in the reaction process, the reaction condition is mild, the reaction time is short, and separation is simple; compared with a traditional chemical catalysis method, byproducts and wastes are not generated; compared with an anhydrous catalytic system, the product yield is high.

The invention discloses a liposome composition with firming and anti-wrinkle effects as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The liposome composition contains a phalaenopsis aphrodite extract, a radix pseudostellariae extract, hydrogenated lecithin, PEG-40 hydrogenated castor oil, polyglycerol-6 octoate and phytol, and further contains retinol palmitate, tocopherol and other antioxidants, a humectant, a bacteriostatic agent and a solvent. The liposome composition with the particle size of 100-300 nm is obtained through high-pressure microjet treatment, the active ingredient encapsulation efficiency of the liposome composition is high, the liposome composition has the excellent transdermal absorption effect, meanwhile, the composition can efficiently promote synthesis of type I collagen, the firming and anti-wrinkle effects are remarkable, and the liposome composition is suitable for preparing skin care products such as water aqua, emulsion, cream, ointment or facial masks.

The invention discloses a skin repair mask and a preparation method thereof, and relates to the technical field of facial beauty care, the skin repair mask comprises a mask base material and mask liquid attached to the mask base material, the NMN / retinol palmitate / ergothioneine compound nanocrystal moisturizing and repairing lotion is prepared from the following components in parts by weight: 0.5 to 3.0 parts of liposome-coated NMN, 0.3 to 2.0 parts of retinol palmitate / ergothioneine compound nanocrystal, 5.0 to 15.0 parts of moisturizing and repairing component, 0.1 to 2.0 parts of soothing and anti-inflammatory component, 0.1 to 0.8 part of thickening agent, 0.1 to 0.5 part of preservative, 0.01 to 0.1 part of chelating agent, 0.01 to 0.2 part of essence and the balance of deionized water, wherein the total amount of the components is 100 parts. The mask has anti-aging and deep repairing effects, has a good anti-allergic effect, and is adaptive to sensitive skin.

The invention relates to a transdermal sustained release microsphere-liposome double-layer microcapsule as well as a preparation method and application thereof. The transdermal sustained-release microsphere-liposome double-layer microcapsule comprises an inner-layer microsphere and an outer-layer liposome, the main components of the inner-layer microsphere are a tremella aurantialba sporocarp extract and retinol palmitate, the retinol palmitate is wrapped by the tremella aurantialba sporocarp extract, and the main component of the outer-layer liposome is silybum marianum seed oil. Compared with the prior art, the application adopts a multi-component synergistic effect and a double-layer micro-capsule delivery system, and breaks through the limitation that only a single target spot is focused and the mildness and effectiveness are contradictory in the prior art aiming at the characteristics that the sensitive skin is fragile in barrier, easy to stimulate inflammation and low in tolerance; and the multi-dimensional anti-aging effects of barrier repair, collagen regeneration, oxidation resistance and inflammation resistance are realized.

This invention relates to a high-content, high-stability hydroxypinazone retinate composition, comprising retinyl palmitate, hydroxypinazone retinate, and diisopropyl adipate; the components are mixed, heated and stirred until homogeneous, and then cooled to obtain the final product. This invention successfully solves the problems of poor stability and low active ingredient content in hydroxypinazone retinate compositions, improving the bioavailability of hydroxypinazone retinate in the prepared microemulsions, and can be applied in the preparation of cosmetics.