32 results about "Self association" patented technology

A triplex forming oligonucleotide is complementary pursuant to the G / T or A / G recognition motif to a homopurine, or substantially homopurine target sequence in double stranded nucleic acids, and at least one and preferably all of the guanine bases are replaced by their pyrazolo[3,4-d]pyrimidine analog, namely by 6-amino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one. The oliginucleotides containing the pyrazolo[3,4-d]pyrimidine analog of guanine exhibit a lesser degree of self-association, and lack the nucleophilic nitrogen atom in the 7 position of guanine. The latter feature results in a diminished extent of self-crosslinking in ODNs which also have a covalently attached cross-linking agent.

The invention is a self-correlation carrier frequency deviation estimation algorithm based on known serial correlation and the implementation device thereof, belonging to the field of digital information transmission technology. The algorithm comprises: coherent demodulating the original receiving sequence to get a coherent demodulation receiving sequence by emitted known sequence; self-correlation calculating the coherent demodulation receiving sequence to get a self-correlation sequence; phase angle calculating the self-correlation sequence to get original self-correlation phase angle sequence; differentiating, modular operating and summarizing the original self-correlation phase angle to get a new self-correlation phase angle sequence; and calculating carrier frequency deviation estimation according to the new self-correlation phase angle sequence and original self-correlation phase angle result. By introducing phase angle differentiation, modular operation and summarization, the invention eliminates the phase angle blurring problem in simple frequency deviation estimation algorithm, realizes linear frequency deviation estimation having maximal estimated scope and minimum variance; the invention also further lowers the linear frequency deviation estimation of estimated variance when maximizes the estimated scope.

A coating composition including a reinforcing agent. The coating composition may include one or more radiation-curable monofunctional monomers, one or more radiation-curable multifunctional monomers or oligomers, a photoinitiator, and a reinforcing agent. The monofunctional monomers, multifunctional monomers, and multifunctional oligomers may include acrylate groups. The reinforcing agent may be an acrylic co-polymer that includes two or more repeat units. At least one of the repeat units includes chemical groups that enable self-association of the acrylic co-polymer. Self-association of the acrylic co-polymer may improve the tensile strength of coatings formed from the coating compositions.

The present invention relates to formulations comprising sucrose, and methods of making such formulations, wherein the sucrose content promotes the reduction or elimination of the reversible self-association (RSA) tendency of the antibody in the formulation. The present invention also relates to formulations comprising an anti-PDGFR-alpha antibody or antibody fragment. Such antibodies can be used in various methods of treatment. The application further relates to a method of eliminating or reducing the RSA tendency of antibodies in a formulation.

Herein described as liquid formulations of antibodies and biologically active fragments thereof that specifically bind to human ICOS polypeptide, exhibit increased in vivo ADCC activity and undergo reversible self-association in solution.

The invention provides a self-association linked polymer coils and a preparation method thereof. The preparation method comprises the following steps: 1) dissolving a surfactant and an oil-soluble initiator in base oil as an oil phase; 2) dissolving a hydrophobic monomer, a water-soluble crosslinking monomer, a conventional water-soluble monomer and a water-soluble initiator in water to prepare an aqueous solution with total mass percentage content of 20-70% as a water phase; 3) mixing the water phase in the step 2) and the oil phase in the step 1) and emulsifying a mixture to form a W / O-type microemulsion with a dispersion phase as the water phase and a continuous phase as the oil phase; and 4) introducing ginert gas in the W / O-type microemulsion formed in the step 3) to initiate a polymerization to obtain the self-association linked polymer coils. A modifying and flooding agent aqueous solution system by using the self-association linked polymer coils is especially suitable for high-permeability oil reservoir.

The invention relates to cell death inducing chimeric antigen receptors (D-CAR). In particular, the present invention relates to cell death inducing chimeric antigen receptors which comprise at least one death domain in their endodomain, including cell death inducing chimeric antigen receptors comprising within their death domains modifications which attenuate the self-association and / or binding to pro-apoptotic or pro-necrotic adaptor proteins, such as FADD or TRADD. Moreover, the present invention relates to an engineered immune cell expressing at its surface a cell death inducing CAR of the present invention and, optionally, an activating chimeric antigen receptor, wherein the extracellular ligand-binding domains of the cell death inducing CAR and the activating CAR bind to different antigens. The engineered immune cell may furthermore comprise at least one edited (e.g., inactivated) gene selected from TCR genes, immune check point genes, genes involved in drug resistance, and combinations thereof.

The present application discloses a chromatographic process for separating protein components of a protein-containing solution, the solution comprising an insulin peptide and one or more di- or polyvalent metal ions, the insulin peptide being capable of self-association and / or structural change in the presence of di- or polyvalent metal ions, the process comprising the steps of: a) applying the protein-containing solution to a column of a chromatographic solid phase material, wherein the loading of the insulin peptide is at least 6.0 g per liter of column volume (g / LCV); and b) eluting the insulin peptide from the solid phase material using an eluent having a pH of at the most 8.5; and collecting a pool of the insulin peptide corresponding to at least 75% by weight of the insulin peptide applied to the column in step (a).

The invention relates to a method for preparing a methyl cellulose and lipid packaging film, and belongs to the technical field of food packaging. Methyl cellulose and a lipid are used as main film forming materials, and a plasticizing agent is used as an accessory material. The preparation method comprises the following steps: (1) weighing methyl cellulose, adding a hot ethanol water solution into the methyl cellulose, and adding the plasticizing agent and the lipid after the methyl cellulose is fully dissolved to form a mixed film liquid; (2) performing a synergistic processing of microwave and ultrasonic on the mixed film liquid, forming a film through tape casting, drying and taking out the film to obtain the methyl cellulose-based composite food packaging film. Compared with the prior art, the lipid-containing methyl cellulose film liquid is subjected to the synergistic processing of microwave and ultrasonic to prompt the crystallization of a lipid substance on the surface of a methyl cellulose substrate through a self-association effect, so that a dense lipid layer is formed and a double-layer structure is formed finally. The double-layer film prepared by the method is non-toxic, edible and biodegradable, can be formed by only one tape casting, is simple in film preparation process, meanwhile, has excellent mechanical and moisture-resistant properties, and can be used as a food inner package.

A two-chain insulin analogue contains a modified A-chain polypeptide and a modified B-chain polypeptide. The A-chain polypeptide comprises one or more of: a His or Glu substitution at position A8, a Glu substitution at position A14; and a Gln or Arg substitution at positon A17. The B-chain polypeptide comprises one or more of: a deletion of the amino acids at position B1, B1-B2, B1-B3, B30 or a combination thereof; an Ala or Glu substitution at position B2; a Glu substitution at position B3. The analogue exhibits thermodynamic stability in a zinc-free solution, decreased self-association, maintains biological potency, and no increased mitogenicity. The analogue exhibits resistance to chemical degradation and physical degradation. A method of treating a patient with diabetes mellitus or obesity comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient.

The invention relates to a data association processing method and system and electronic equipment. The data association processing method comprises the steps that a first information table is generated according to basic log data, wherein each record in the first information table is uniquely identified with a first key field and a second key field; in a preset time period, the first key fields and the corresponding second key fields in the first information table are self-associated, and a second information table is generated; the quantity of the first key fields corresponding to at least two second key fields is subjected to statistical analysis after self-association in the second information table, and a third information table is generated; and a fourth information table is generatedaccording to the first information table, the second information table and the third information table, wherein the fourth information table comprises indexes representing association among at leasttwo second key fields.

The present invention relates to the use of camptothecin derivatives as anti-HIV agents that disrupt self-association of the viral infectivity factor (Vif) found in HIV and other retroviruses. The present invention also relates to methods of identifying agents that disrupt VIf self-association and methods of using these agents, including methods of treating or preventing HIV infection.

The invention discloses an anti-choking additive for methanol fuel of a vehicle. The invention aims to solve the technical problems of high vapor pressure, difficulty in starting, unsmooth oil supply, vehicle shaking, and the like, in the vehicle of the present methanol gasoline. The anti-choking additive comprises more than two of the following components in parts by weight: 1-10 parts of butanone, 1-10 parts of methyl propionate, 1-10 parts of n-butyl alcohol, 1-10 parts of butyl hexanol, 1-5 parts of 2-sulfydryl benzothiazole, 1-20 parts of petroleum calcium sulfonate and 5-20 parts of petroleum ether. The anti-choking additive disclosed by the invention is added for protecting the original self-association effect and properties of methanol, preventing the methanol gasoline from higher vapor pressure and boosting the safety, reliability and smooth oil path in the storage and use processes.

The invention provides a method and device for associating data of interfaces in a packet domain of the network. The method and device are realized in a server with a multi-core processor, signaling data association and user data association are implemented by different processing cores, and self association and mutual association of Gb signaling data, IuPS signaling data, Gn signaling data and user data are realized. In addition, access to an association list is realized by a shared memory, management of a user identity information association list is separated from that of a PDP session association list, user information can be flexibly updated, and the success rate of association is improved, more complete user identity information, user position information and the like can be provided, fault points are reduced compared with distributed processing in the prior art, and the system maintainability is improved.

The invention discloses a preparation method of a self-extinction matte emulsion with a gemini structure. The surface flatness of the paint film is reduced in the drying process through self-association of gemini surfactant groups on the polymer chain, the gloss is reduced, and the matte effect is generated. According to the method, a paint film with a matte effect can be obtained without adding extinction powder, the characteristics of low cost, high stability and the like, and a wide application prospect can be obtained.

The present invention discloses amphiphilic 1,4-dihydropyridine derivatives useful for the preparation of a composition for delivering nucleotide containing compounds into a target cell and / or its nucleus. Said composition comprises 1,4-dihydropyridine derivatives having a good DNA condensing capacity and capability of self-association. Also disclosed are composition comprising said derivatives complexed with nucleotide containing compounds as well methods for the producing of said complexes. The invention is also related to the use of said 1,4-dihydropyridine derivatives for manufacturing systems for delivering nucleotide containing compounds useful in gene therapy and DNA vaccination.

The present invention provides compositions that are capable of being dispersed in a target medium. The compositions include characteristic use particles entrapped within a physical entrapment phase, wherein the physical entrapment phase is dispersible in the target medium. Accordingly, the compositions of the present invention physically prevent the agglomeration or self-association of the characteristic use particles. Also disclosed are processes for manufacturing compositions that are capable of being dispersed in a target medium.

A coating composition including a reinforcing agent. The coating composition may include one or more radiation-curable monofunctional monomers, one or more radiation-curable multifunctional monomers or oligomers, a photoinitiator, and a reinforcing agent. The monofunctional monomers, multifunctional monomers, and multifunctional oligomers may include acrylate groups. The reinforcing agent may be an acrylic co-polymer that includes two or more repeat units. At least one of the repeat units includes chemical groups that enable self-association of the acrylic co-polymer. Self-association of the acrylic co-polymer may improve the tensile strength of coatings formed from the coating compositions.

The invention discloses a navigation alcohol fuel air lock prevention additive for an automobile, and solves the technical problems of difficult starting, unsmooth oil supply and vehicle shaking during use of an automobile due to high steam pressure of a current navigation alcohol fuel. The air lock prevention additive comprises two or more selected from the following reagents, in parts by weight:5-20 parts of trimethylcyclohexanone, 5-20 parts of polyether silicone, 5-10 parts of dimethyl carbonate, 5-15 parts of morpholine, 2-8 parts of fatty acid copper, and 5-15 parts of petroleum ether.After the air lock prevention additive provided by the invention is added, original self-association effect and original performance of methanol can be protected, a relatively high vapor pressure of the navigation alcohol fuel can be avoided, and safety, reliability and smooth oil ways in the storage and use process can be promoted.

The invention is a self-correlation carrier frequency deviation estimation algorithm based on known serial correlation and the implementation device thereof, belonging to the field of digital information transmission technology. The algorithm comprises: coherent demodulating the original receiving sequence to get a coherent demodulation receiving sequence by emitted known sequence; self-correlation calculating the coherent demodulation receiving sequence to get a self-correlation sequence; phase angle calculating the self-correlation sequence to get original self-correlation phase angle sequence; differentiating, modular operating and summarizing the original self-correlation phase angle to get a new self-correlation phase angle sequence; and calculating carrier frequency deviation estimation according to the new self-correlation phase angle sequence and original self-correlation phase angle result. By introducing phase angle differentiation, modular operation and summarization, the invention eliminates the phase angle blurring problem in simple frequency deviation estimation algorithm, realizes linear frequency deviation estimation having maximal estimated scope and minimum variance; the invention also further lowers the linear frequency deviation estimation of estimated variance when maximizes the estimated scope.

The invention relates to a method and device for measuring two-dimensional infinitesimal displacement with a single primary color by using a computer camera, and further provides a method and device for contactless displacement measurement with a computer camera. The device comprises a computer and a computer camera, and is provided with a camera shooting and single-color frame matcher. In the invention, the texture of a reflective surface of an object to be measured can be analyzed by adopting a brightness self-association coefficient calculation method and the size of a comparison window is automatically regulated; one of three primary color frames is selected as an object to be measured, primary color frames selected for a former and a later frames are subjected to a cross correlation matching computation to determine that the highest frame-frame correlation degree is achieved when the cross correlation coefficient value is minimum and close to zero, thereby an instant displacement, a total displacement and an instant speed are obtained; whether to upgrade a reference frame or regulate the position of the comparison window is determined according to result on the instant displacement, the total displacement and the instant speed, the size of a cross association operator array which is used for search matching is regulated automatically; therefore, the method and the device are favorable for overcoming the impacts of other wavelengths and changes to the measurement, and further improving the measurement speed.

The present invention discloses a community shared service method based on the Internet of Things. The method comprises that: a plurality of community information of at least one communication terminal user is obtained; the communication terminal compares the first virtual public service weight with the first virtual service threshold to determine whether public service metadata corresponding to each service content can be associated with a first virtual public service group; the communication terminal compares the first virtual consumption weight with the first virtual consumption threshold to determine whether consumption metadata corresponding to each consumption information can be associated with a first virtual consumption group; the first virtual public service group and the first virtual consumption group form a first virtual group; and the first virtual group of the communication terminal user and the first virtual group of at least one social user of the communication terminal execute self-association according to the first key. The present invention further discloses a community shared service system based on the Internet of Things for implementing the method. By virtue of the technical scheme of the present invention, self-association of metadata between the communication terminal and the social user can be realized, the Internet of things is more convenient, and the trouble of negative commented metadata is eliminated.

The invention relates to a method and a device for measuring small two-dimensional displacement by using three primary colors of a computer camera, and provides a method and a device for performing non-contact measurement on displacement by taking the computer camera as a displacement sensor. The device is formed by connecting a camera and an ordinary computer, is configured with a camera filmingprogram and a three-primary color luminance frame matching program and can acquire the optimum matching comparison window by self-association calculation on a reference frame; three primary color image frames in a photoelectric sensor sensitive spectrum are subjected to cross-association matching calculation respectively to acquire the displacement of the corresponding primary color image frame; the displacement is averaged to be used as the instant relative displacement vector of an object, so that total displacement vector and instant speed thereof are obtained, and whether the reference frame and the optimum matching comparison window thereof are updated or not is determined according to the results, and the size of a cross-association operator array performing search matching is adjusted automatically. The accuracy of the device is less than one pixel unit, and the device has a certain capacity of ambient light interference resistance, and is advanced in technology and low in cost.

There is provided an amino acid sequence comprised within the PV E1 protein region A delineated by amino acids 352 and 439, and any derivative variant or fragment thereof, necessary for the oligomerization of the E1 protein. This amino acid sequence is capable of self-association and of associating with the full length E1 protein and any derivative, variant or fragment thereof comprising the sequence of this invention. A specific aspect of this first embodiment, the amino acid domain of this invention delimited by amino acids 353 to 438 of the PV E1 protein. More particularly, the amino acid domain of this invention is as defined by SEQ ID NO. 2. There is also provided a cross-linking assay to directly measure the level of oligomerization (or inhibition thereof) of the E1 protein. In accordance with a fourth embodiment of this invention, there is provided a N-terminally truncated E1 protein. More particularly, one aspect of this fourth embodiment encompasses the E1 protein delimited by amino acid 72 to 649 (SEQ ID NO. 78).

The invention discloses a gas barrier preventing additive for vehicle navigation alcohol fuel. The technical problems of difficult starting, poor oil supply and vehicle shaking caused by high vapor pressure of existing alcohol navigation alcohol fuel during use of automobiles are solved. The gas barrier preventing additive comprises two or above of the following components: in parts by weight, 10-30 parts of trimethylcyclohexanone, 15-20 parts of rosin water, 5-10 parts of dibutyl ether, 0.5-5 parts of isopropyl ether, 10-15 parts of morpholine, 1-8 parts of octanal and 5-20 parts of petroleumether. Through addition of the gas barrier preventing additive, original self-association of methanol and original performance of methanol can be protected, the high vapor pressure of the navigationalcohol fuel can be avoided, and safety and reliability and smoothness of an oil passage during storage and use can be promoted.

The invention relates to a method and device for measuring two-dimensional infinitesimal displacement with a single primary color by using a computer camera, and further provides a method and device for contactless displacement measurement with a computer camera. The device comprises a computer and a computer camera, and is provided with a camera shooting and single-color frame matcher. In the invention, the texture of a reflective surface of an object to be measured can be analyzed by adopting a brightness self-association coefficient calculation method and the size of a comparison window is automatically regulated; one of three primary color frames is selected as an object to be measured, primary color frames selected for a former and a later frames are subjected to a cross correlation matching computation to determine that the highest frame-frame correlation degree is achieved when the cross correlation coefficient value is minimum and close to zero, thereby an instant displacement, a total displacement and an instant speed are obtained; whether to upgrade a reference frame or regulate the position of the comparison window is determined according to result on the instant displacement, the total displacement and the instant speed, the size of a cross association operator array which is used for search matching is regulated automatically; therefore, the method and the device are favorable for overcoming the impacts of other wavelengths and changes to the measurement, and further improving the measurement speed.

There is provided an amino acid sequence comprised within the PV E1 protein region A delineated by amino acids 352 and 439, and any derivative variant or fragment thereof, necessary for the oligomerization of the E1 protein. This amino acid sequence is capable of self-association and of associating with the full length E1 protein and any derivative, variant or fragment thereof comprising the sequence of this invention. A specific aspect of this first embodiment, the amino acid domain of this invention delimited by amino acids 353 to 438 of the PV E1 protein. More particularly, the amino acid domain of this invention is as defined by SEQ ID NO. 2. There is also provided a cross-linking assay to directly measure the level of oligomerization (or inhibition thereof) of the E1 protein. In accordance with a fourth embodiment of this invention, there is provided a N-terminally truncated E1 protein. More particularly, one aspect of this fourth embodiment encompasses the E1 protein delimited by amino acid 72 to 649 (SEQ ID NO. 78).