The invention discloses a ketone-removing additive for removing ketone substances from packaging card paper, and application of the additive. The ketone-removing additive comprises organic amine and a catalyst, wherein the organic amine is one or more of ethanediamine, propane diamine, butanediamine, ethanolamine, guanidine and dimethyl biguanide; the catalyst is one or more of acetic acid, propionic acid, citric acid and malic acid; the mass ratio of the organic amine to the catalyst is 1.5: 1 to 2.5: 1. The ketone-removing additive is added into a water dispersible coating solution containing acrylic resin at room temperature to obtain a water-based coating solution, wherein the mass percent of the ketone-removing additive in the coating solution is 0.5%-5.0%. The water-based coating solution is used for removing the ketone substances from the packaging card paper. An experiment shows that the water-based coating solution can be used for effectively removing the ketone substances from the packaging card paper. The water-based coating solution is low in production cost, cannot change the structure and the characteristics of the paper in a ketone removing process, and cannot influence the subsequent processing process of the packaging card paper.