A variable damping vibration isolator based on ultrasonic motor adjustment comprises a base, a magneto-rheological damper and an adapter plate, and mainly utilizes the magneto-rheological damper to support and consume vibration energy. The magneto-rheological damper comprises an upper cavity, a lower cavity, a connecting ring, a permanent magnet, a throttling hole, a magnetic conductive ring, an ultrasonic motor and the like. Magneto-rheological fluid is stored in an upper cavity and a lower cavity formed by corrugated pipes, the middle section and the two ends of each cavity are used as inputand output ends of vibration, so the simulation piston movement of the damper without dynamic and static clearances is achieved, fluid is pushed to flow, fluid damping is provided, and leakage can beavoided during long-term on-orbit work. Moreover, the magneto-rheological damper adopts an ultrasonic motor to drive the permanent magnet to rotate, and the overlap ratio of the permanent magnet andthe throttling holes is adjusted, that is, the number of the throttling holes entering the magnetic field of the permanent magnet is adjusted, and the damping size of the damper is changed. After theultrasonic motor rotates in place, outage self-locking can be achieved. The ultrasonic motor is used for adjusting the number of the orifices in the magnetic field, and the damping is adjusted.