The invention provides an intelligent constant-temperature 
cold chain box. The intelligent constant-temperature 
cold chain box comprises a box body and a box door, wherein the box door is positioned on the side surface of the box body; the box body is of a groove-shaped structure with a forward opening, and the top surface, the bottom surface and the three side surfaces of the box body at least comprise three temperature 
layers from outside to inside, namely a vacuum layer, a heat 
insulation layer and a 
refrigerant layer; the vacuum layer is made of an insulating material, the heat insulationlayer is made of a 
radiation-proof material, the 
refrigerant layer comprises a plurality of 
refrigerant units, and the refrigerant units are tightly arranged; and notches of the box body and the box door are sealed by soft 
silica gel sealing strips. The intelligent constant-temperature 
cold chain box further comprises a coded lock, a monitoring module, an intelligent terminal and a 
cloud server. The vacuum layer and the heat 
insulation layer of the box body doubly guarantee the constant-temperature transportation effect of the cold chain box. The chain box is provided with the monitoring module and the intelligent terminal, so that the temperature in the box body can be checked online and remotely, temperature collection, storage and 
wireless transmission are integrated, and the intelligent constant-temperature cold chain box can be widely applied to refrigerated medicines, food and articles needing constant-temperature transportation.