The invention relates to a separation method of a Fischer-tropsch synthesized crude product. The method comprises a plurality of technological steps: crude separation of products, oil hydrogenation, alkane refining, solvent oil refining, wax hydrogenation, wax refining and the like, and according to different synthesis temperatures of the Fischer-tropsch synthesized crude product, different quantities of various high-added-value products such as naphtha, n-pentane, n-heptane, DSP100, DSP40, DSP80 or DSP110 solvent oil, C50, C70 or C80 series wax, H1 and H105 series wax and the like can be obtained. The separation method has the advantages of improving the added value of the Fischer-tropsch synthesized crude product, and being simple in technological flow, and easy for industrial production.