The invention discloses a device for pressing a puncture site after cerebral vascular intervention operation. According to the key points of the technical scheme, the device includes a pressing memberand a fixing device, the pressing member includes a pressing shell and an elastic pressing pad, the pressing shell and the elastic pressing pad are enclosed to form a first filling inner cavity, a first filling machine is arranged outside the pressing shell, pressure gauge is arranged on the pressing shell, a blocking plate is slidably connected to the sliding shell, a limiting structure is arranged on the pressing shell, the first filling machine includes a first filling airbag, an inlet through hole and a discharge through hole are formed in two sides of the first filling airbag, a first check valve is installed on the inlet through hole, a second check valve is installed on the discharge through hole, an outlet of the second check valve communicates with the first filling inner cavitythrough a first connecting pipeline, a first discharge channel is arranged on the pressing shell, and a control valve is arranged on the first discharge channel. The device can control the pressing range, adjust the pressing position and control the pressing pressure, can convenient perform cold compress or hot compress operation, and reduces the workload of staff.